X-ray powder diffraction data for 17-hydroxy-16-methyl-9,11-epoxypregna-1,4,6-triene-3,20-dione, C22H26O4

Wang, Q.; Bian, Xiaowei; Chen, X.

doi:10.1017/s088571561900054x

Cited by 1 publication

(1 citation statement)

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“…Diffraction. X-ray powder diffraction (XRPD) 22 of OHP were measured before and after the solubility experiment to confirm the uniformity of crystal form. XRPD characterization was performed on an X-ray diffractometer (Rigaku Mini Flex 600) with Cu Kα radiation.…”

Section: X-ray Powdermentioning

confidence: 99%

Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

Zhao,

Pan,

Xiong

et al. 2024

ACS Omega

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The static gravimetric method was used to measure the solubility of 17-α hydroxyprogesterone (OHP) in 13 pure solvents ranging from 278.15 to 323.15 K. The results indicate that the experimental solubility of OHP increases with increasing temperature. The experimental solubility data were correlated by the selected van’t Hoff model, λh model, modified Apelblat model, Yaws model, and nonrandom two-liquid (NRTL) model. The fitting results show that the Yaws model can give better correlation results by fitting 13 different pure solvent systems. Based on the NRTL equation, the thermodynamic analysis of solubility data showed that the mixing process was spontaneous. The Hansen solubility parameters (HSPs) and solvent effect were applied to explore these solubility characteristics. Finally, the thermodynamic properties Δsol H°, Δsol S°, Δsol G°, %ξH, and %ξTS were calculated by the van’t Hoff model equation. The results showed that Δsol H°, Δsol S°, and Δsol G° are all positive values, indicating that the dissolution of OHP in the selected solvent is an endothermic reaction with increasing entropy.

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Section: X-ray Powdermentioning

confidence: 99%