X‐ray Photolysis To Release Ligands from Caged Reagents by an Intramolecular Antenna Sensitive to Magnetic Resonance Imaging

Abstract

Sensitive to light: A metal‐complex‐sensitized organic probe was developed to release ligands on excitation by X‐ray or γ irradiation (see picture). This overcomes a current limitation in permitting use of photolysis as an experimental tool in otherwise inaccessible materials that are not penetrated by light (ET=electron transfer).

Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

“…459 These metal complexes act as intramolecular antennae and convert part of the energy resulting in electron transfer and subsequent fragmentation of the quinolines.…”

Quinoline‐Derived Two‐Photon‐Sensitive Octupolar Probes

“…The synthesis of compound 2 b followed a similar strategy, as shown in Scheme . The desired aminoquinoline 15 , obtained from 11 by Cu I ‐catalyzed amination of the protected alcohol 14 was subjected to a two‐directional Buchwald–Hartwig coupling in the presence of 2.2 equiv of 7‐bromoquinoline 14 , in the presence of [Pd 2 (dba) 3 ]/ t Bu 3 P catalyst and t BuONa as a base in toluene (83 % yield). The desired triacetate 2 b was isolated upon HF–pyridine deprotection and acylation (75 % overall yield for two steps).…”

How to control proteins with light in living systems

“…Another important avenue of development will be to overcome the drawbacks of light in the visible range (absorption and diffusion) to interrogate living organisms. From the latter point of view, it will be important to thoroughly explore other ways to trigger and read out physiological changes: other triggers that could be used to control proteins, such as X rays 86 , acoustic waves 87 , temperature jumps 88 and so on, may soon be added to the toolbox for protein control. …”