X-ray phase imaging of biological soft tissue using a direct-sensing x-ray HARP tube camera

Hirano, Keiichi; Miyoshi, T.; Igarashi, Noriyuki; Takeda, Takeshi; Wu, Jing; Tt, Lwin; Kubota, Masakazu; Egami, N.; Tanioka, Kenkichi; Kawai, Toshiaki; Wakatsuki, Soichi

doi:10.1088/0031-9155/52/9/014

Cited by 5 publications

(4 citation statements)

References 23 publications

(24 reference statements)

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“…This journal is © The Royal Society of Chemistry 2007 on extremely sensitive detectors that should allow the collection of entire data sets in time periods of a few seconds 51,52. …”

mentioning

confidence: 99%

Fast electron density methods in the life sciences—a routine application in the future?

Luger

2007

Org. Biomol. Chem.

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The understanding of mutual recognition of biologically interacting systems on an atomic scale is of paramount importance in the life sciences. Electron density distributions that can be obtained from a high resolution X-ray diffraction experiment can provide--in addition to steric information--electronic properties of the species involved in these interactions. In recent years experimental ED methods have seen several favourable developments towards successful application in the life sciences. Experimental and methodological advances have made possible on the one hand high-speed X-ray diffraction experiments, and have allowed on the other hand the quantitative derivation of bonding, non-bonding and atomic electronic properties. This has made the investigation of a large number of molecules possible, and moreover, molecules with 200 or more atoms can be subject of experimental ED studies, as has been demonstrated by the example of vitamin B12. Supported by the experimentally verified transferability concept of submolecular electronic properties, a key issue in Bader's The Quantum Theory of Atoms in Molecules, activities have emerged to establish databases for the additive generation of electron densities of macromolecules from submolecular building blocks. It follows that the major aims of any experimental electron density work in the life sciences, namely the generation of electronic information for a series of molecules in a reasonable time and the study of biological macromolecules (proteins, polynucleotides), are within reach in the near future.

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“…This journal is © The Royal Society of Chemistry 2007 on extremely sensitive detectors that should allow the collection of entire data sets in time periods of a few seconds 51,52. …”

mentioning

confidence: 99%

Fast electron density methods in the life sciences—a routine application in the future?

Luger

2007

Org. Biomol. Chem.

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“…[17][18][19] However, the DEI approach for crystal analyzer-based imaging is limited by the refraction angular resolution of the crystal analyzer that delivers a limited contrast resolution for distinguishing and visualizing the structure in soft tissues. 20,21) By using a double-crystal analyzer 22) or an asymmetric crystal analyzer, 23) the sharpness of the reflectivity curve can be modified to obtain smaller refraction angles; however, the obtained refraction angle range is not a qualitative leap. To cope with this situation, in this paper, we propose a multi diffraction enhanced imaging (MDEI) technique for enhancing contrast that can potentially resolve minute changes in electron density owning to the sharp rise in the reflectivity curve 24) and provide remarkable contrast-to-noise ratio (CNR).…”

Section: Introductionmentioning

confidence: 99%

Visualization of soft tissues by highly sensitive X-ray crystal analyzer-based multi diffraction enhanced imaging

Sunaguchi

Lin

et al. 2015

Jpn. J. Appl. Phys.

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In this paper, we propose a novel multi diffraction enhanced imaging (MDEI) technique to improve contrast resolution owning to the sharp rise of the reflectivity curve and high contrast-to-noise ratio (CNR). MDEI is derived from the diffraction enhanced imaging (DEI) technique. Here, DEI and MDEI phase contrast tomograms are compared. The results show that MDEI offers higher contrast resolution, while DEI has higher spatial resolution. This study provided indications for developments and applications of X-ray crystal analyzer-based imaging to obtain a higher contrast resolution.

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“…The HARP camera has been used for high-definition television and has even been used to capture star light images. Hirano et al (20) developed a direct sensing X-ray HARP tube camera for X-ray phase imaging. They used a beryllium plate, rather than a glass plate, as the faceplate of the tube, in order to minimize the loss of X-rays due to absorption, and a 15 µm thick HARP target was directly formed on it.…”

Section: Detectionmentioning

confidence: 99%

X-ray Spectrometry

et al. 2008

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In this review, we focus on the most significant and essential progress in X-ray spectrometry (XRS) published during the period 2006-2007 covering the following topics: developments and improvements in the detection performance and instrumentation of X-ray techniques and X-ray optics, new quantification models in X-ray spectra and data evaluation, micro-X-ray fluorescence (µ-XRF) including 3D-XRF, imaging techniques such as tomography and holography methods for 2D or 3D imaging of microstructures, electron probe microanalysis (EPMA), total reflection X-ray fluorescence (TXRF), particle-induced X-ray emission (PIXE) analysis, and X-ray absorption spectrometry (XAS). Finally, different applications in each subfield of XRS are described. Since the previous review, the sections of µ-XRF and 3D-XRF are newly introduced.An international group of scientists published two overviews on XRS (1, 2) in the Journal of Analytical Atomic Spectrometry covering the period 2006-2007 in the principal field of XRS analytical spectroscopic methods and instruments. These review articles involve all the important sections of XRS in nine chapters: reviews, instrumentation, spectrum analysis, matrix correction and calibration, X-ray optics and microfluorescence, synchrotron radiation, TXRF, portable and mobile X-ray fluorescence (XRF), and online XRF and applications. In the present review, we use a different method of classifying the information published in the literature during the 2006-2007 period: detection, instrumentation (except detectors) and optics, quantification models and related fundamental data, tomography and holography methods as primary tools of X-ray imaging, TXRF, EPMA, PIXE, XAS, and a final chapter that reviews the application of these methods in geology, environmental research, industry, biology, and medicine.Two practically useful books were published in 2006-2007. The handbook entitled Practical X-ray Fluorescence Analysis was edited by five famous German researchers (3). Following the historical progress of XRF, the basic and recent developments in X-ray sources, X-ray optics, and X-ray detectors are described. Quantification, specimen preparation, and special configurations, such as TXRF and micro-XRF, and their applications in environ-* To whom correspondence should be addressed.

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X-ray phase imaging of biological soft tissue using a direct-sensing x-ray HARP tube camera

Cited by 5 publications

References 23 publications

Fast electron density methods in the life sciences—a routine application in the future?

Fast electron density methods in the life sciences—a routine application in the future?

Visualization of soft tissues by highly sensitive X-ray crystal analyzer-based multi diffraction enhanced imaging

X-ray Spectrometry

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