X-Ray Phase-Contrast Imaging with Nanoradian Angular Resolution

Diémoz, Paul C.; Endrizzi, Marco; Zapata, C. E.; Pešić, Z. D.; Rau, Christoph; Bravin, A.; Robinson, Ian; Olivo, Alessandro

doi:10.1103/physrevlett.110.138105

Cited by 84 publications

(96 citation statements)

References 21 publications

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“…[14][15][16][17][18] While previously tomographic images acquired with a monochromatic synchrotron source were shown, 8 in this paper, the first tomographic images obtained from an EI XPCi system implemented with a commercial laboratory xray tube are presented. The obtained results demonstrate the superiority of phase over attenuation based imaging, as well as the feasibility of imaging at doses well within the limits of what is considered acceptable for in vivo, e.g., small animal imaging applications.…”

Section: Introductionmentioning

confidence: 99%

Low-dose phase contrast tomography with conventional x-ray sources

et al. 2014

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Purpose:The edge illumination (EI) x-ray phase contrast imaging (XPCi) method has been recently further developed to perform tomographic and, thus, volumetric imaging. In this paper, the first tomographic EI XPCi images acquired with a conventional x-ray source at dose levels below that used for preclinical small animal imaging are presented. Methods: Two test objects, a biological sample and a custom-built phantom, were imaged with a laboratory-based EI XPCi setup in tomography mode. Tomographic maps that show the phase shift and attenuating properties of the object were reconstructed, and analyzed in terms of signal-tonoise ratio and quantitative accuracy. Dose measurements using thermoluminescence devices were performed. Results:The obtained images demonstrate that phase based imaging methods can provide superior results compared to attenuation based modalities for weakly attenuating samples also in 3D. Moreover, and, most importantly, they demonstrate the feasibility of low-dose imaging. In addition, the experimental results can be considered quantitative within the constraints imposed by polychromaticity. Conclusions:The results, together with the method's dose efficiency and compatibility with conventional x-ray sources, indicate that tomographic EI XPCi can become an important tool for the routine imaging of biomedical samples.

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Section: Introductionmentioning

confidence: 99%

Low-dose phase contrast tomography with conventional x-ray sources

et al. 2014

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“…2]. Second, refraction angles were extracted using two signals simulated at opposite EI configurations 8,14 , from which phase shifts were retrieved via numerical integration:…”

Section: Simulationsmentioning

confidence: 99%

“…To date, several XPCi modalities have been developed [2][3][4][5][6][7] . The edge illumination (EI) method stands out due to its high phase sensitivity and versatility [8][9][10] . In particular, the method was shown to be applicable both with highly coherent synchrotron radiation, as well as with incoherent radiation from conventional x-ray tubes 11 .…”

Section: Introductionmentioning

confidence: 99%

“…In fact, the refraction angle is expressed by α = (λ/2π) · ∂Φ/∂y, where Φ is the phase shift and λ is the wavelength. Separate attenuation and refraction maps can be extracted through a procedure based on the acquisition of two images in opposing EI configurations 8,14 . From refraction angle images, the phase shift can be recovered via one-dimensional integration ("phase retrieval"), as required for truly quantitative imaging and computed tomography (CT) 15 .…”

Section: Introductionmentioning

confidence: 99%

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A continuous sampling scheme for edge illumination x-ray phase contrast imaging

Hagen

Coan

Bravin

et al. 2015

Journal of Applied Physics

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We discuss an alternative acquisition scheme for edge illumination (EI) x-ray phase contrast imaging (XPCi) based on a continuous scan of the object, and compare its performance to that of a previously used scheme, which involved scanning the object in discrete steps rather than continuously. By simulating signals for both continuous and discrete methods under realistic experimental conditions, the effect of the spatial sampling rate is analysed with respect to metrics such as image contrast and accuracy of the retrieved phase shift. Experimental results confirm the theoretical predictions.Despite being limited to a specific example, the results indicate that continuous schemes present advantageous features compared to discrete ones. Not only can they be used to speed up the acquisition, but they also prove superior in terms of accurate phase retrieval. The theory and experimental results provided in this study will guide the design of future EI experiments through the implementation of optimized acquisition schemes and sampling rates.

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“…The energy distribution is usually broad, with an energy spread of DE= E ¼ 0:3 À 0:7. EI was proven to provide high sensitivity, at synchrotrons as well as in laboratory-scale implementations, [9][10][11] to efficiently use the entire spectrum produced by conventional X-ray tubes 12 and to be suitable for quantitative three-dimensional imaging. 13,14 Here, we propose a laboratory-based approach for multimodal XPCI, which uses a conventional rotating anode Xray source, two partially absorbing optical elements, and a flat panel sensor.…”

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confidence: 99%

Laboratory-based X-ray phase-contrast imaging with misaligned optical elements

Endrizzi

Basta

Olivo

2015

Applied Physics Letters

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We report on a laboratory X-ray phase-contrast imaging technique based on the edge illumination principle that substantially relaxes the existing limitations on system set up and data acquisition, allowing an increase in tolerance of misalignments by at least two orders of magnitude. The robustness of this approach was systematically studied by means of experiments with our prototype. Numerical simulations were also performed in order to assess the dependence of the image quality on the data acquisition scheme. The results show that errors in the positioning of the masks within a 1° range for all the angles, and within 1 mm range of translation, do not noticeably affect image quality. We also show that, if the misalignment does not exceed few tens of micrometers, three intensity projections are sufficient to effectively retrieve the three representations of the sample, allowing for optimization of dose or time efficiency even with a non-ideal system.

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X-Ray Phase-Contrast Imaging with Nanoradian Angular Resolution

Cited by 84 publications

References 21 publications

Low-dose phase contrast tomography with conventional x-ray sources

Low-dose phase contrast tomography with conventional x-ray sources

A continuous sampling scheme for edge illumination x-ray phase contrast imaging

Laboratory-based X-ray phase-contrast imaging with misaligned optical elements

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