X-ray micromodulated luminescence tomography in dual-cone geometry

Cong, Wenxiang; Pan, Zhengwei; Filkins, Robert J.; Srivastava, A.M.; Ishaque, A.; Stefanov, Plamen; Wang, Ge

doi:10.1117/1.jbo.19.7.076002

Cited by 24 publications

(12 citation statements)

References 16 publications

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“…Liu et al applied a cone beam based XLCT to small animal imaging with the XLCT reconstruction from measurements at a single-view and they reported a location error of 1.43 mm [8]. To improve spatial resolution, Cong et al proposed a micro-modulated X-ray scanning method utilizing focused X-ray beams onto a spot of a few micrometers in size [9,10]. And we designed a microscopic XLCT (microXLCT) system by using a superfine single pinhole collimator, in which X-ray beams from the X-ray source were collimated by a small pinhole with a diameter of 100 µm [11].…”

Section: Introductionmentioning

confidence: 99%

Multiple pinhole collimator based X-ray luminescence computed tomography

Zhang

Zhu

Lun

et al. 2016

Biomed. Opt. Express

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X-ray luminescence computed tomography (XLCT) is an emerging hybrid imaging modality, which is able to improve the spatial resolution of optical imaging to hundreds of micrometers for deep targets by using superfine X-ray pencil beams. However, due to the low X-ray photon utilization efficiency in a single pinhole collimator based XLCT, it takes a long time to acquire measurement data. Herein, we propose a multiple pinhole collimator based XLCT, in which multiple X-ray beams are generated to scan a sample at multiple positions simultaneously. Compared with the single pinhole based XLCT, the multiple X-ray beam scanning method requires much less measurement time. Numerical simulations and phantom experiments have been performed to demonstrate the feasibility of the multiple X-ray beam scanning method. In one numerical simulation, we used four X-ray beams to scan a cylindrical object with 6 deeply embedded targets. With measurements from 6 angular projections, all 6 targets have been reconstructed successfully. In the phantom experiment, we generated two X-ray pencil beams with a collimator manufactured in-house. Two capillary targets with 0.6 mm edgeto-edge distance embedded in a cylindrical phantom have been reconstructed successfully. With the two beam scanning, we reduced the data acquisition time by 50%. From the reconstructed XLCT images, we found that the Dice similarity of targets is 85.11% and the distance error between two targets is less than 3%. We have measured the radiation dose during XLCT scan and found that the radiation dose, 1.475 mSv, is in the range of a typical CT scan. We have measured the changes of the collimated X-ray beam size and intensity at different distances from the collimator. We have also studied the effects of beam size and intensity in the reconstruction of XLCT.

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Section: Introductionmentioning

confidence: 99%

Multiple pinhole collimator based X-ray luminescence computed tomography

Zhang

Zhu

Lun

et al. 2016

Biomed. Opt. Express

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“…To date, the luminescent agents have been largely inorganic and further development will be required to enable this approach to be used routinely. The narrow XLCT beams lead to a relatively long sampling time, so that a polycapillary lens has been utilized to generate a focused high-intensity micrometersized x-ray spot, 182,183 enabling faster scanning without degrading spatial resolution or imaging depth. Cone-beam XLCT systems can also fully utilize the x-ray dose and shorten the scan time at the cost of reduced resolution.…”

Section: Scintillation-based Molecular Imaging In Vivomentioning

confidence: 99%

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

Pogue

Wilson

2018

J. Biomed. Opt.

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X-ray and optical technologies are the two central pillars for human imaging and therapy. The strengths of x-rays are deep tissue penetration, effective cytotoxicity, and the ability to image with robust projection and computed-tomography methods. The major limitations of x-ray use are the lack of molecular specificity and the carcinogenic risk. In comparison, optical interactions with tissue are strongly scatter dominated, leading to limited tissue penetration, making imaging and therapy largely restricted to superficial or endoscopically directed tissues. However, optical photon energies are comparable with molecular energy levels, thereby providing the strength of intrinsic molecular specificity. Additionally, optical technologies are highly advanced and diversified, being ubiquitously used throughout medicine as the single largest technology sector. Both have dominant spatial localization value, achieved with optical surface scanning or x-ray internal visualization, where one often is used with the other. Therapeutic delivery can also be enhanced by their synergy, where radiooptical and optical-radio interactions can inform about dose or amplify the clinical therapeutic value. An emerging trend is the integration of nanoparticles to serve as molecular intermediates or energy transducers for imaging and therapy, requiring careful design for the interaction either by scintillation or Cherenkov light, and the nanoscale design is impacted by the choices of optical interaction mechanism. The enhancement of optical molecular sensing or sensitization of tissue using x-rays as the energy source is an important emerging field combining x-ray tissue penetration in radiation oncology with the molecular specificity and packaging of optical probes or molecular localization. The ways in which x-rays can enable optical procedures, or optics can enable x-ray procedures, provide a range of new opportunities in both diagnostic and therapeutic medicine. Taken together, these two technologies form the basis for the vast majority of diagnostics and therapeutics in use in clinical medicine.

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“…Furthermore, Zhang et al have also proven that the spatial resolution of XLCT is about double the size of the xray beam diameter (11). Cong et al have proposed the concept to use a dual-cone geometry of a focused x-ray beam to achieve high spatial resolution XLCT imaging and validated their idea with numerical simulations (12). However, until now, there is no reported XLCT imaging systems able to explore high spatial resolution imaging of up to 150 micrometers for x-ray excitable nanophosphors in deep tissues.…”

Section: Introductionmentioning

confidence: 99%

Focused x-ray luminescence computed tomography: experimental studies

Lun

Zhang

2019

Multimodal Biomedical Imaging XIV

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X-ray luminescence computed tomography (XLCT) is an emerging hybrid molecular imaging modality and has shown great promises in overcoming the strong optical scattering in deep tissues. Though the narrow x-ray beam based XLCT imaging has been demonstrated to obtain high spatial resolution at depth, it suffers from a relatively long measurement time, hindering its practical applications. Recently, we have designed a focused x-ray beam based XLCT imaging system and have successfully performed imaging in about 7.5 seconds per section for a mouse sized object. However, its high spatial resolution capacity has not been fully implemented yet. In this paper, with a superfine focused x-ray beam we design a focused-x-ray luminescence tomography (FXLT) system for spatial resolution up to 94 μm. First, we have described our design in details. Then, we estimate the performance of the designed FXLT imaging system. Lastly, we have found that the spatial resolution of FXLT can be further improved by reducing the scan step size, which has been demonstrated by numerical simulations.

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X-ray micromodulated luminescence tomography in dual-cone geometry

Cited by 24 publications

References 16 publications

Multiple pinhole collimator based X-ray luminescence computed tomography

Multiple pinhole collimator based X-ray luminescence computed tomography

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

Focused x-ray luminescence computed tomography: experimental studies

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