X-Ray Inhibition of Gastrin-Stimulated Acid Secretion in Relation to Mucosal Activity of (Na + ,K + )-Dependent ATPase

Vaughan, B.E.; Cummins, Joseph T.; Pessotti, Rita L.

doi:10.2307/3573337

Cited by 2 publications

(2 citation statements)

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“…Acid production indices came back to normal 3-3.5 months after irradiation [11]. Vaughan et al [4] noted in anesthetized, acute gastric fistula rats a transient inhibition of spontaneous (nonstimulated) gastric acid secretion immediately after a dose of 240 R (2.4 Gy), whole-body X-ray irradiation, which resumed promptly after gastrin injection. In addition, gastrin-stimulated acid secretion was inhibited after a dose of 600 or 1200 R (6 or 12 Gy) X-ray irradiation.…”

Section: Discussionmentioning

confidence: 99%

“…In man, therapeutic pelvic irradiation is associated with widespread, persistent changes in gastrointestinal function [3]. Studies in rats and guinea pigs indicated that exposure to irradiation could suppress gastric acid secretion [4,5,6]. More recently, however, Lehy et al [7] reported an increase in gastric acid output and plasma gastrin levels in rats exposed to 2-or 6-Gy whole-body gamma radiation.…”

Section: Introductionmentioning

confidence: 99%

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Acute Effect of Gamma Irradiation on Gastric Acid Secretion and Gastric Mucosal Integrity in the Rat

Salam

Hadajat

Bayomy

et al. 2005

The Scientific World JOURNAL

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The effect of 3- or 6-Gray (Gy) whole-body gamma irradiation on basal and stimulated gastric acid secretion was studied in pylorus-ligated rats. Different groups of rats were irradiated with a single 3- or 6-Gy fraction and examined 7 days after irradiation. Exposure to 3-Gy fraction led to marked increase in basal (nonstimulated) gastric acid output in the 4-h pylorus-ligated rat (47.5% compared with unirradiated controls). After exposure to 6 Gy, only 18.2% increase in gastric acid output was noted compared with unirradiated controls. Under pentagastrin or histamine stimulation, gastric acid secretion in those irradiated with 3- or 6-Gy fraction was markedly reduced compared to that of unirradiated controls. Exposure to 3- or 6-Gy gamma irradiation intensified the degree of gastric mucosal injury evoked by indomethacin or 50% ethanol in a dose-dependent manner. It is concluded that in the pylorus-ligated rat model, lower doses of gamma irradiation increase basal gastric acid secretion and impair the gastric mucosal barrier with marked increase in its permeability to H+ following stimulation of acid secretion or exposure to barrier breakers. Exposure to irradiation is likely to result in failure of the parietal cell to respond to direct stimulation with histamine or pentagastrin.

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Section: Discussionmentioning

confidence: 99%