X-ray-induced chromosome aberrations in mouse dictyate oocytes. I. Time and dose relationships

Brewen, J.G.; Payne, H.S.; Preston, R. Julian

doi:10.1016/0027-5107(76)90173-1

Cited by 34 publications

(5 citation statements)

References 22 publications

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“…Considering also other data from literature reporting studies on immature and mature oocytes, a conclusion may be formulated that mature human oocytes are more sensitive to radiation than immature oocytes. Similar observations were described in the first studies of such a profile conducted on mice [20,64,65,68,75,76]. This was also confirmed in later research on other model species, e.g.…”

Section: Genotoxicity Of Ir For Female Embryonic Cells In Mammalssupporting

confidence: 86%

“…They may be caused by genetic factors or environmental effects (or a combination of both factors), exerting an effect at the stage of foetal life. Considering the complexity of the etiopathogenesis of developmental defects, few researchers connected their occurrence with exposure to IR [27,64,65,66,67,68]. A synthesis of research in this area is also hindered by a great variety of changes which may be considered as 'defects', and various stages of development when the observations were carried out, e.g.…”

Section: Specificity Of Female Gametogenesis and Studies Of Radiosensmentioning

confidence: 99%

“…Over the last 10-15 yea, in Poland, the average age of a woman giving birth for the first time has increased by 4 years [11]. The discussed tendency is associated, among others, with an increase in the number of divorces in Poland: in 2017, 65,000 marital couples were divorced [11], while in 2018 -63,000 [12], as well as making new relationships, in which persons from broken marriages are trying to have a baby at an older age [13].…”

Section: Introduction and Objectivementioning

confidence: 99%

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Effect of ionizing radiation on the female reproductive system

Skrzypek¹,

Wdowiak²,

Panasiuk³

et al. 2019

Ann Agric Environ Med.

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Introduction and objective. The tendency towards postponement of maternity implies a greater exposure of female germ cells to damaging environmental effects, including ionizing radiation (IR). Progress in paediatric oncology, based on the use of radiotherapy, also implies the occurrence of gonadal dysfunctions and subsequent female fertility disorders. Therefore, it seems justifiable to systematize the state of knowledge concerning the effect of IR on the female reproductive system. Brief description of the state of knowledge. A considerable part of studies concerning the effect of IR on female germ cells have been conducted on animals. Their extrapolation to humans is hindered because in animal studies high acute exposures are applied, which do not reflect human environmental exposures characterized by chronic low dose exposure. Studies on animals provide a heterogenous image, which hinders the formulation of unequivocal conclusions and indicates that radiosensitivity depends, i.a. on IR dose, stage of development of oocytes, the applied marker of the effects of IR, or on the species. LD50 of human oocytes is estimated to be below 2 Gy. The effect of IR depends, i.a. on the dose fractionation and the age (older women are more radiosensitive). In females, the effective sterilizing dose is: at birth 20.3 Gy, at 10 years 18.4 Gy, at 20 years 16.5 Gy, whereas at 30 years 14.3 Gy, which is associated with the available pool of ovarian follicles. Conclusions. Within the range of low doses received as a result of environmental exposure to IR, there is no evidence for the occurrence of either adverse pregnancy outcomes, nor fertility disorders in females. These effects may be related to the cancer radiotherapy, or exposure to high IR doses during nuclear accidents.

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Section: Genotoxicity Of Ir For Female Embryonic Cells In Mammalssupporting

confidence: 86%

Section: Specificity Of Female Gametogenesis and Studies Of Radiosensmentioning

confidence: 99%

Section: Introduction and Objectivementioning

confidence: 99%

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Effect of ionizing radiation on the female reproductive system

Skrzypek¹,

Wdowiak²,

Panasiuk³

et al. 2019

Ann Agric Environ Med.

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“…Overall, the observed general view is that mature oocytes are more radio-sensitive than are immature oocytes. These observations were already reported by early studies in mouse [ 16 , 37 , 46 , 54 , 55 , 65 , 80 ]. Later on, this trend was confirmed in other model species such as rat and guinea pig.…”

Section: Radiation-induced Genotoxic Effects In Mammalian Female Gsupporting

confidence: 81%

Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

Ruiz‐Herrera

García

Garcia-Caldés

2012

Genes

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Ionizing radiation damages DNA and induces mutations as well as chromosomal reorganizations. Although radiotherapy increases survival among cancer patients, this treatment does not come without secondary effects, among which the most problematic is gonadal dysfunction, especially in women. Even more, if radio-induced DNA damage occurs in germ cells during spermatogenesis and/or oogenesis, they can produce chromosomal reorganizations associated with meiosis malfunction, abortions, as well as hereditary effects. However, most of our current knowledge of ionizing radiation genotoxic effects is derived from in vitro studies performed in somatic cells and there are only some experimental data that shed light on how germ cells work when affected by DNA alterations produced by ionizing radiation. In addition, these few data are often related to mammalian males, making it difficult to extrapolate the results to females. Here, we review the current knowledge of radiobiology and reproduction, paying attention to mammalian females. In order to do that, we will navigate across the female meiotic/reproductive cycle/life taking into account the radiation-induced genotoxic effects analysis and animal models used, published in recent decades.

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“…Information on chromosomal aberrations is also available for the female mouse. Doseresponse curves for x ray, gamma ray, and neutron-induced chromosome aberrations in maturing, as well as immature, mouse oocytes have been presented (e.g., Brewen et al 1976;Brewen et al 1977;Straume et al 1991). (Straume et al 1991).…”

Section: Chromosomal Aberrationsmentioning

confidence: 99%

Biological effectiveness of neutrons: Research needs

Casarett¹,

Braby²,

Broerse³

et al. 1994

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As Chairman of the Science Panel of the Committee on Interagency Radiation Research and Policy Coordination (CIRRPC), I am pleased to provide you with the final report on the Biological Eflectiveness of Neutrons: Research Needs. This report was written by an independent, multidisciplinary, knowledgeable task group of eminent scientists. It was prepared for the CIRRPC Science Panel in response to a request from the Department of Energy to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This request is consistent with the provision in CIRRPC's Charter that "...[the CIRRPC] Science Panel assist the Committee in preparing an appropriate research agenda on selected radiation issues... I' The CIRRPC Science Panel and knowledgeable scientists from both the United States and European radiation research communities reviewed an earlier draft of the report. The task group carefully considered all of the specific comments received and incorporated such comments as were considered appropriate. Overall, the report received high marks for quality. The Science Panel was provided a prepublication copy of the final report to note my changes made as a result of the review. The Science Panel considers this report an important contribution to science and recommends that it be made available to Federal agencies and other individuals and organizations interested in planning radiation research agendas.

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X-ray-induced chromosome aberrations in mouse dictyate oocytes. I. Time and dose relationships

Cited by 34 publications

References 22 publications

Effect of ionizing radiation on the female reproductive system

Effect of ionizing radiation on the female reproductive system

Radiobiology and Reproduction—What Can We Learn from Mammalian Females?

Biological effectiveness of neutrons: Research needs

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