X-ray enabled detection and eradication of circulating tumor cells with nanoparticles

Hossain, Mainul; Luo, Yang; Sun, Zhaoyong; Wang, Chaoming; Zhang, Minghui; Fu, Hanyu; Qiao, Yong; Su, Ming

doi:10.1016/j.bios.2012.06.020

Cited by 44 publications

(37 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, T2PE results from low energy electrons including Auger electrons emitted from the nanomaterials after absorbing X-ray photons, and T2PE is confined to the surface region of the nanomaterials -within tens of nm from their surface. [8][9][10] T2PE is hence called local or nanoscale physical enhancement. 8 More recently evidence has shown that there are other mechanisms including chemical enhancement (CE) and anti-enhancement (AE), both relying on the surface of the nanomaterials and can either further increase or reduce the enhancement by nanomaterials under X-ray irradiation.…”

Section: Introductionmentioning

confidence: 99%

Average Physical Enhancement by Nanomaterials under X-ray Irradiation

Davidson

Guo

2014

J. Phys. Chem. C

View full text Add to dashboard Cite

We for the first time used highly water soluble silica-covered gold nanoparticles (AuNP@SiO 2 ) in water to successfully isolate average physical enhancement from other enhancements such as nanoscale physical enhancement, chemical enhancement and antienhancement, and obtained the highest enhancement slope of 1.03 per weight percent (wp -1 ) and the highest experimental enhancement factor of 4.5 fold (ߝ ௫௧ =4.5; and ߝ ௫௧ = 0 for no enhancement) at 7.5 wp of gold in water. The slope and ߝ ௫௧ agree with the theoretically predicted values obtained from simulation of enhancement of X-rays by gold nanoparticles in water, and the experimental enhancement coefficient (ߛ = ߝ ௫௧ /ߝ ௧ , 0 ≤ ߛ ≤ 1) is approximately 0.90. The enhancement dependency on X-ray energy, silica layer thickness and sample thickness are studied experimentally and theoretically. The results presented here elucidate the mechanism of the average physical enhancement by nanomaterials under X-ray irradiation.KEYWORDS X-ray nanochemistry, enhancement of X-ray effect, nanomaterials, nanoscale energy deposition, physical enhancement.

show abstract

Section: Introductionmentioning

confidence: 99%

Average Physical Enhancement by Nanomaterials under X-ray Irradiation

Davidson

Guo

2014

J. Phys. Chem. C

View full text Add to dashboard Cite

show abstract

“…The peak at 1459 cm −1 is a characteristic signal for folic acid corresponding to the phenyl ring. The occurrence of this peak in the Raman spectrum of FA-MPpIX is an evidence for the successful conjugation of FA to MPpIX [40][41][42].…”

Section: Raman Characterizationmentioning

confidence: 92%

Enhancement of protoporphyrin IX performance in aqueous solutions for photodynamic therapy

Homayoni

Jiang

Zou

et al. 2015

Photodiagnosis and Photodynamic Therapy

View full text Add to dashboard Cite

Molecular modification of protoporphyrin IX (PpIX) was conducted to improve its water solubility and therapeutic performance for photodynamic therapy. The carboxylic acid and the two nitrogen atoms in the core of PpIX molecule were protonated following by conjugation with 3-aminopropyl triethoxysilane (APTES). Then, folic acid (FA) was conjugated to the APTES-coated PpIX (MPpIX) through chemical bonding between FA and protonated PpIX. The results showed that APTES coating can stabilize PpIX and increase its water solubility. Consequently, this leads to the enhancement in luminescence and singlet oxygen production. Upon X-ray irradiation, singlet oxygen can be detected in the MPpIX but not in PpIX. This means that MPpIX can be used for deep cancer treatment as X-ray can penetrate deeply into tissue. Molecular modification also reduces the dark toxicity of PPIX and increases their cell uptake. All these traits indicate that the Molecular modification of PpIX may potentially improve the efficacy of photodynamic therapy for cancer treatment.

show abstract

“…A technique for detection and killing of CTCs has been described that uses magnetic and bismuth nanoparticles, X-ray fl uorescence spectrometry, and X-rays (Hossain et al 2012 ). Nanoparticles are modifi ed with tumor targeting agents and conjugated with tumor cells through folate receptors over-expressed on cancer cells.…”

Section: Detection and Destruction Of Ctcs With Nanoparticles And X-raysmentioning

confidence: 99%

Personalized Therapy of Cancer

Jain

2015

Textbook of Personalized Medicine

View full text Add to dashboard Cite

X-ray enabled detection and eradication of circulating tumor cells with nanoparticles

Cited by 44 publications

References 45 publications

Average Physical Enhancement by Nanomaterials under X-ray Irradiation

Average Physical Enhancement by Nanomaterials under X-ray Irradiation

Enhancement of protoporphyrin IX performance in aqueous solutions for photodynamic therapy

Personalized Therapy of Cancer

Contact Info

Product

Resources

About