“…In this work, we chose the benzimidazole azaheterocycle to generate the antihyperglycemic hybrids because this scaffold is of great importance due to its appreciated pharmacological actions in medicinal chemistry and applications in organic synthesis, acting as a privileged structure [3,[9][10][11], which can selectively modulate diverse targets associated with the pathogenesis of diabetes. On the other hand, the election of benzylidenethiazolidine-2,4-dione as p-coumaric acid bioisostere (the major natural component widely found in grapes, red wine, tomatoes, spinach, garlic, and coffee) was taken into account because several acid bioisosteres have demonstrated antidiabetic effects [4][5][6][7][8].…”