X‐linked spinomuscular atrophy

Warner, Carolyn L.; Griffin, J. E.; Wilson, Jean D.; Jacobs, Lawrence; Murray, Kathleen; Fischbeck, K. H.; Dickoff, David; Griggs, R.C.

doi:10.1212/wnl.42.11.2181

Cited by 75 publications

(24 citation statements)

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“…3,11,14,23 Patients may have signs of androgen insensitivity such as gynecomastia, impotence, and testicular atrophy. 21,25 Our patients previously carried diagnoses that included Kugelberg-Welander disease, amyotrophic lateral sclerosis, hereditary motor and sensory neuropathy, and limb-girdle muscular dystrophy. Despite this, our patients were remarkably homogeneous in their presentations both clinically and electrophysiologically.…”

Section: Discussionmentioning

confidence: 99%

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy

1999

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Section: Discussionmentioning

confidence: 99%

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy

1999

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“…Patient 2 refused the skin biopsy. Warner et al [27] reported a family with 3 brothers with SBMA and a decreased androgen-binding capacity on GSF, whereas in 5 other patients from 3 families the binding capacity was normal. Interestingly, this variable androgen-binding ca pacity is not associated with disparity in neuromuscular and endocrine symptoms.…”

Section: Discussionmentioning

confidence: 99%

Molecular Analysis of the Androgen Receptor Gene in Kennedy’s Disease

Lumbroso

Lobaccaro²,

Vial³

et al. 1997

Horm Res

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We have performed a molecular analysis of the androgen receptor gene in two families with suspected Kennedy’s disease (spinal and bulbar muscular atrophy, SBMA) with the aim of making a firm diagnosis of the disease. The 2 patients studied were sporadic cases. Both presented clinical signs compatible with the diagnosis of SBMA: limb and facial muscular weakness of adult onset progressing toward muscular atrophy. Clinical signs of partial androgen insensitivity syndrome usually observed in SBMA were present only in patient 2. Enzymatic amplification of the CAG repeat region of exon 1 of the androgen receptor gene was performed on genomic DNA. PCR products were submitted to agarose or acrylamide electrophoresis for size evaluation. Precise determination of the CAG number was performed by direct sequencing of purified amplification products. Androgen receptor gene analysis was also performed in 2 sisters of patient 1 and in the mother, sisters and daughter of patient 2. Androgen receptor-binding activity was also determined on cultured genital skin fibroblasts of patient 1. Analysis of PCR products showed in both patients a single band that was much larger in size than the control. The expansion of the CAG repeat number was confirmed by direct sequencing: the exact number of CAG was 47 in patient 1 and 42 in patient 2 (n = 12-32). The 2 studied sisters of patient 1 did not present the abnormal fragment, demonstrating they are not carriers for the disease. Conversely, the mother, sisters and daughter of patient 2 presented both normal and mutated alleles. The migration of the labelled PCR products on a sequencing gel revealed a meiotic instability of expanded CAG repeat in family 2. Moreover, patient 1 had a decreased androgen-binding capacity on cultured genital skin fibroblasts. In both families, analysis of the androgen receptor gene permitted us to diagnose SBMA in the patients and to establish the carrier status in siblings. These results correspond to the literature data and confirm the usefulness of CAG repeat evaluation in the diagnosis of Kennedy’s disease. They highlight the relationship between the androgen receptor and motoneuron growth, development and regeneration.

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“…Radiotherapy has been shown to be effective in the prevention of gynaecomastia in patients receiving hormonal therapy for prostate cancer [14]. Muscular atrophy can also result from low circulating testosterone levels [15]. …”

Section: Potential Disadvantages Of Long-term Treatmentmentioning

confidence: 99%

The Future of Endocrine Treatment in Early Prostate Cancer: Concluding Remarks

Schröder¹

1999

European Urology

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X‐linked spinomuscular atrophy

Cited by 75 publications

References 0 publications

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy

Molecular Analysis of the Androgen Receptor Gene in Kennedy’s Disease

The Future of Endocrine Treatment in Early Prostate Cancer: Concluding Remarks

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X‐linked spinomuscular atrophy

Cited by 75 publications

References 0 publications

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy

Distinguishing clinical and electrodiagnostic features of X-linked bulbospinal neuronopathy

Molecular Analysis of the Androgen Receptor Gene in Kennedy&rsquo;s Disease

The Future of Endocrine Treatment in Early Prostate Cancer: Concluding Remarks

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Molecular Analysis of the Androgen Receptor Gene in Kennedy’s Disease