Wyeomyia-Virus Isolations in Trinidad, West Indies *

Aitken, T. H. G.; Spence, L.; Jonkers, A. H.; Anderson, Charles R.

doi:10.4269/ajtmh.1968.17.886

Cited by 10 publications

(14 citation statements)

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“…The vertebrate host range has not been defined. A single isolation of MCAV from the rodent species Proechimys guyannensis and another of AMBV from Proechimys iheringi have been recorded (de Souza Lopes et al, 1975;Travassos da Rosa et al, 1998), whereas serological data may also indicate a bird reservoir (Aitken et al, 1968;de Souza Lopes et al, 1975). Aside from the original description of each virus, more frequent isolations were reported for WYOV from Colombia, Brazil, Panama and Trinidad (Aitken et al, 1968;Srihongse & Johnson, 1965), although the specificity of the serological identification may not have been definitive in all cases.…”

Section: Introductionmentioning

confidence: 99%

“…A single isolation of MCAV from the rodent species Proechimys guyannensis and another of AMBV from Proechimys iheringi have been recorded (de Souza Lopes et al, 1975;Travassos da Rosa et al, 1998), whereas serological data may also indicate a bird reservoir (Aitken et al, 1968;de Souza Lopes et al, 1975). Aside from the original description of each virus, more frequent isolations were reported for WYOV from Colombia, Brazil, Panama and Trinidad (Aitken et al, 1968;Srihongse & Johnson, 1965), although the specificity of the serological identification may not have been definitive in all cases. Their role in human disease remains uncertain, but antibodies to AMBV (de Souza Lopes et al, 1975) and WYOV were reported from healthy people in the areas of virus isolation (Brazil for AMBV, Trinidad and Panama for WYOV), and WYOV has been isolated from a febrile patient (Aitken et al, 1968;Srihongse & Johnson, 1965).…”

Section: Introductionmentioning

confidence: 99%

“…Aside from the original description of each virus, more frequent isolations were reported for WYOV from Colombia, Brazil, Panama and Trinidad (Aitken et al, 1968;Srihongse & Johnson, 1965), although the specificity of the serological identification may not have been definitive in all cases. Their role in human disease remains uncertain, but antibodies to AMBV (de Souza Lopes et al, 1975) and WYOV were reported from healthy people in the areas of virus isolation (Brazil for AMBV, Trinidad and Panama for WYOV), and WYOV has been isolated from a febrile patient (Aitken et al, 1968;Srihongse & Johnson, 1965). Here we report the nearly complete sequence for all three genome segments of these viruses and present phylogenetic analyses that show a relationship to Guaroa virus (GROV) for their S segments, but a closer link to other Bunyamwera serogroup viruses for their M and L segments, and identify two viruses as intra-group reassortants.…”

Section: Introductionmentioning

confidence: 99%

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Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships

Chowdhary

Street

Rosa

et al. 2012

Journal of General Virology

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Phylogenetic analyses can give new insights into the evolutionary history of viruses, especially of viruses with segmented genomes. However, sequence information for many viral families or genera is still limited and phylogenies based on single or short genome fragments can be misleading. We report the first genetic analysis of all three genome segments of Wyeomyia group viruses Wyeomyia, Taiassui, Macaua, Sororoca, Anhembi and Cachoeira Porteira (BeAr328208) in the genus Orthobunyavirus of the family Bunyaviridae. In addition, Tucunduba and Iaco viruses were identified as members of the Wyeomyia group. Features of Wyeomyia group members that distinguish them from other viruses in the Bunyamwera serogroup and from other orthobunyaviruses, including truncated NSs sequences that may not counteract the host’s interferon response, were characterized. Our findings also suggest genome reassortment within the Wyeomyia group, identifying Macaua and Tucunduba viruses as M-segment reassortants that, in the case of Tucunduba virus, may have altered pathogenicity, stressing the need for whole-genome sequence information to facilitate characterization of orthobunyaviruses and their phylogenetic relationships.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships

Chowdhary

Street

Rosa

et al. 2012

Journal of General Virology

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“…Another group of viruses within the genus Orthobunyavirus, the Wyeomyia group viruses, have truncated NSs sequences that may not code for functional proteins (81). However, antibodies were detected in humans, and the viruses are associated with febrile illness (52,82,83). Determination of whether the inability of HEBV, TAIV, and KIBV to replicate in vertebrate cells is due to the absence of an NSs protein or is encoded within another genome region needs further in-depth studies.…”

Section: Discussionmentioning

confidence: 99%

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Marklewitz

Zirkel

Rwego

et al. 2013

J Virol

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“…The work done in Trinidad provided valuable information on circulating viruses (Aitken et al 1956(Aitken et al , 1960(Aitken et al , 1968aJonkers et al 1968a;Price, 1978b), taxonomic classification of the vectors (Aitken et al 1968c), and their associated ecological characteristics Jonkers et al 1966). These studies resulted in the identification and characterization of hundreds of arboviral isolates, primarily from the Bush Bush Forest, which is an approximately 0.85-sq km region within the Nariva swamp in southeastern Trinidad (Aitken et al 1968c;Jonkers et al 1968aJonkers et al , 1968bWorth et al 1968).…”

mentioning

confidence: 99%

Serological Evidence of Flaviviruses and Alphaviruses in Livestock and Wildlife in Trinidad

Thompson

Auguste

Coombs

et al. 2012

Vector-Borne and Zoonotic Diseases

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Seroprevalence rates of selected arboviruses in animal populations in Trinidad were determined using serum samples collected between 2006 and 2009 from horses (n = 506), cattle (n = 163), sheep (n = 198), goats (n = 82), pigs (n = 184), birds (n = 140), rodents (n = 116), and other vertebrates (n = 23). The sera were screened for antibodies to West Nile virus (WNV), St. Louis encephalitis virus (SLEV), Ilheus virus (ILHV), Bussuquara virus (BSQV), Venezuelan equine encephalitis virus (VEEV), eastern equine encephalitis virus (EEEV), and western equine encephalitis virus (WEEV), using hemagglutination inhibition assay (HIA) and epitope-blocking enzyme-linked immunosorbent assays (ELISA). Antibodies to SLEV were detected in a total of 49 (9.7%) horses, 8 (4.9%) cattle, 1 (1.2%) goat, 2 (1.4%) wild birds, and 3 (2.2%) wild rodents by both methods. In contrast, antibodies to EEEV, VEEV, and WNV were detected only in horses, at rates of 4.3%, 0.8%, and 17.2%, respectively, by ELISA, and IgM capture ELISA was WNV-positive in 3 (0.6%) of these sera. Among locally bred unvaccinated horses that had never left Trinidad, seroprevalence rates against WNV were 12.1% and 17.2% by ELISA and HIA, respectively. The presence of WNV-and SLEV-specific antibodies in a representative sample of horse sera that were both ELISA-and HIA-seropositive was confirmed by plaque reduction neutralization testing (PRNT). Antibodies to ILHV and BSQV were not detected in any of the serum samples tested (i.e., sera from horses, other livestock, and wild birds in the case of ILHV, and wild mammals in the case of BSQV). The data indicate the presence of WNV in Trinidad, and continuing low-level circulation of SLEV, EEEV, and VEEV.

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Wyeomyia-Virus Isolations in Trinidad, West Indies *

Cited by 10 publications

References 0 publications

Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships

Genetic characterization of the Wyeomyia group of orthobunyaviruses and their phylogenetic relationships

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

Serological Evidence of Flaviviruses and Alphaviruses in Livestock and Wildlife in Trinidad

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