Wuhan Covid-19 Synthetic Origins and Evolution

Perez, Jean-claude

doi:10.29121/granthaalayah.v8.i2.2020.221

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…To this evidence of manipulation of CODONS synonymous with Spike of one or the other between SARS-CoV2 and beats RATG13, to the question "which of the 2 was manipulated?" (Perez, 2020), , (Castro-Chavez, 2020). We can assert that it is the SARS-Cov2 spike that has been manipulated to modify synonymous CODONS while retaining the functionality of the same amino acids.…”

Section: 2-sars-cov2 Originsmentioning

confidence: 99%

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Pérez¹

2021

Preprint

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In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 9 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and « 2 mutations » IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFIZER and MODERNA. 9/ Does the CG-rich modification of the synonymous codons of the spikes of the 2 mRNA vaccines affect the expression and quantity of SARS-CoV2 antibodies? Particularly, we suggest the following conjecture at mRNA folding level : CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of "podiums" for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a "hairpin", which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFIZER and MODERNA vaccines. One fact is certain, the 2 mRNAs of the Moderna and Pfizer vaccines will result in a low functionality of the spike vaccine because by doping these sequences in CG rich, their designers, in search of greater STABILITY of these RNAs will have built, according to us , sequences which, as soon as they are inserted into the human host, will seek to mutate, like SARS-CoV2 variants, towards CG ==> UA forms in order to improve, paradoxically, their STABILITY and probably also their LIFETIME.. Particularly, using new biomathematics theoretical methods (Master code and numerical standing waves), and comparing the Spikes of the 2 vaccines Moderna and Phizer, we conclude a very probable difference in stability and shelf life of the 2 respective mRNAs of these 2 vaccines. However, the “State of the Art” will tell you that their 2 protein sequences are strictly identical. However, by having modified their synonymous codons using different strategies, no one can guarantee that the quantity of antibodies generated will be identical in the 2 cases. We can only note the great ADAPTATION power - at the global scale of their genomes - of the most infectious VARIANTS such as the BRAZIL 20J / 501Y.V3 variant (P.1). This is very worrying for the VACCINES <==> VARIANTS run: We demonstrate how the Brazilian variant P.1 which becomes uncontrollable in Brazil in April 2021 has a level of organization of long metastructures of 17,711 bases covering the genome which is 3.6 more important than that of the 2 reference genomes SARS-CoV2 Wuhan and worldwide D614G. We suggest that this high level of overall structure of this variant contributes to the stability of this genome and, possibly, to its greater contagiousness.

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Section: 2-sars-cov2 Originsmentioning

confidence: 99%

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Pérez¹

2021

Preprint

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“…We must introduce and summarize this theoretical method, because it constitutes a strong way to illustrate crucial differences between COVID_19 and bat RaTG13 specific genomes (Figs 4,5, 12 and 13).…”

Section: They Are Called Exogenous Informative Elements (Eie)mentioning

confidence: 99%

“…Upon studying the publication of Pradhan et al [15] we then searched in this genome for possible traces of HIV or even SIV. A first publication [5] reports the discovery of 6 HIV SIV RNA pieces relates to crucial retroviral genes like Envelope and RT Pol. The present article confirms and extends these initial results.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the retroviral part of these regions, which consists of 8 elements from various strains of HIV1, HIV2 and SIV covers a COVID-19, SARS and Bats Coronaviruses Genomes Peculiar Homologous RNA Sequences International Journal of Research -GRANTHAALAYAH BLASTn -NIH NCBI National Center for Biotechnology Information. https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE_TYPE=BlastSearch Relating the « DNA Master Code », a biomathematic method to analyze cohesion/heterogeneity of a DNA/RNA sequence:We must introduce and summarize this theoretical method, because it constitutes a strong way to illustrate crucial differences between COVID_19 and bat RaTG13 specific genomes (Figs 4,5, 12 and 13).…”

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confidence: 99%

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Covid-19, Sars and Bats Coronaviruses Genomes Peculiar Homologous Rna Sequences

Pérez¹,

Montagnier²

2020

Int. J. Res. Granthaalayah

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We are facing the worldwide invasion of a new coronavirus. This follows several limited outbreaks of related viruses in various locations in a recent past (SARS, MERS). Although the main current objective of researchers is to bring efficient therapeutic and preventive solutions to the global population, we need also to better understand the origin of the newly coronavirus-induced epidemic in order to avoid future outbreaks. The present molecular appraisal is to study by a bio-infomatic approach the facts relating to the virus and itsprecursors. This article shows how 16 fragments (Env Pol and Integrase genes) from different strains, both diversified and very recent, of the HIV1, HIV2 and SIV retroviruses have high percentage of homology into parts of the genome of COVID_19. Moreover each of these elements is made of 18 or more nucleotides and therefore may have a function. They are called Exogenous Informative Elements (EIE).. Among these EIE, 12 are concentrated in a very small region of the COVID-19 genome, length less than 900 bases, i.e. less than 3% of the total length of this genome. In addition, these EIE are positioned in two functional genes of COVID-19: the orf1ab and S spike genes. Here are the two main facts which contribute to our hypothesis of a partially synthetic genome: A contiguous region representing 2.49% of the whole COVID-19 genome of which 40.99% is made up of 12 diverse fragments originating from various strains of HIV SIV retroviruses. Some of these 12 EIE appear concatenated. Notably, the retroviral part of these regions, which consists of 8 elements from various strainsof HIV1, HIV2 and SIV covers a length of 275 contiguous bases of COVID-19. The cumulative length of these 8 HIV/SIV elements represents 200 bases. Consequently, the HIV SIV density rate of this region of COVID-19 is 200/275 = 72.73%.

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“…The outbreak of Novel corona virus disease 2019 (COVID-19) is the recent worldwide disaster which is considered by the WHO as a Public Health Emergency of International Concern (PHEIC) (1) . The first case was discovered in Wuhan City, China (2,3) and then after few weeks spread as a global pandemic (4,5) .…”

Section: Introductionmentioning

confidence: 99%

Pharmacists Knowledge and contribution during COVID-19 pandemic in Sudan, 2020

Ahmed¹,

Saeed²

2020

Preprint

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Introduction: Pharmacist's knowledge about different aspects of this pandemic is crucial because it influence their role and contribution as a frontline health care provider, as pharmacies and most of the pharmacy practice sectors are kept open even during lockdowns providing counseling, patient care. Pharmacist can provide valuable services during COVID-19 pandemic, these services may include: provide reliable information on the disease, participate in public education on preventive measures, referring of suspected cases, insuring continuous supply of medicine. Methods: A web-based, cross-sectional study, conducted using survey instrument to obtain responses from Sudanese pharmacists during the period from 26th of May to 3rd of June 2020. A 14-item survey instrument was developed. The web-based cross-sectional study was carried out among Sudanese pharmacists. A self-reported structured questionnaire was divided into three sections: demographic characteristics, questions assessing the knowledge, and one question for the pharmacist contribution during the pandemic. Results: The study showed that 51.1% of pharmacists have good knowledge about the COVID-19. The work experience and education level significantly (P<0.05) influence pharmacist knowledge. Majority of pharmacists contribute to different activities during the pandemic, e.g. providing patients with transmission information (94%), Provide factual and reliable information on the diseases symptoms (93.1%), providing patients with prevention information (91.1%). Conclusion: The study identified that pharmacists have good knowledge about COVID-19 pandemic Also pharmacists contributed in many activities as a frontline health care provider during this pandemic.

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Wuhan Covid-19 Synthetic Origins and Evolution

Cited by 14 publications

References 31 publications

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Covid-19, Sars and Bats Coronaviruses Genomes Peculiar Homologous Rna Sequences

Pharmacists Knowledge and contribution during COVID-19 pandemic in Sudan, 2020

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