WS17.4 Fecal calprotectin and its relation to disease parameters – a longitudinal analysis over 12 years

Fecal calprotectin concentrations in young children with cystic fibrosis: Authors response

“…Similar to our recent and previous studies [2,4,5], Ellemunter et al [3] provided further support for the existence of intestinal inflammation in children and adults with CF. In contrast to Ellemunter et al [2], we found significantly lower calprotectin levels in children less than one year old with CF compared to healthy controls (median [range]: 19.7 [19.5-522.5] vs. 127.7 [19.5-602.6] mg/kg; P = 0.03).…”

“…Notably, fecal calprotectin levels from healthy controls were analysed in the same batch as samples from CF patients and our findings of calprotectin in healthy controls are consistent with published values [8][9][10]. In contrast, there was no healthy control group in the study by Ellemunter et al [3].…”

“…We would like to thank Ellemunter et al [1] for their interest in our study regarding age-related levels of fecal calprotectin in children with cystic fibrosis (CF), less than ten years old [2]. We congratulate Ellemunter et al [3] for publishing a study on fecal calprotectin in patients with CF based on a large sample size and wide range of ages, 0 to 61 years old.…”