WS04.6 Effects of a partially supervised conditioning program in cystic fibrosis: an international multi-centre, randomised controlled trial (ACTIVATE-CF)

Hebestreit, Helge; Kriemler, Susi; Schindler, Christian; Stein, Lothar; Karila, C.; Urquhart, Don S.; Orenstein, David M.; Lands, L. C.; Schaeff, Jonathan; Radtke, Thomas

doi:10.1016/s1569-1993(21)00938-3

Cited by 2 publications

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“…25 However, this study failed to achieve its recruitment target and physical activity was a secondary outcome measure, limiting the strength of this finding. 25 In clinical practice, clinicians should therefore consider both exercise training and physical activity as two separate, yet related, components of the therapeutic regimen, with each specifically addressed during consultations.…”

Section: Exercise In Cystic Fibrosismentioning

confidence: 84%

“…24 A recent large multinational trial recruiting pwCF aged 12 years and older found that a partially supervised exercise program over 12 months significantly increased physical activity levels. 25 However, this study failed to achieve its recruitment target and physical activity was a secondary outcome measure, limiting the strength of this finding. 25 In clinical practice, clinicians should therefore consider both exercise training and physical activity as two separate, yet related, components of the therapeutic regimen, with each specifically addressed during consultations.…”

Section: Exercise In Cystic Fibrosismentioning

confidence: 84%

“…24 31 A recent study, aiming to recruit pwCF who were relatively inactive (≤4 hours of vigorous physical activity per week) to a partially supervised exercise program, failed to achieve its recruitment target, despite recruiting for nearly 4 years, highlighting the challenges in this area. 25 Since the coronavirus disease 2019 pandemic, there has been a rapid increase in telehealth availability and this may serve as a useful adjunct to improve adherence and clinical outcomes for pwCF. 32 33 Similarly, the use of internet-based programs to increase participation of pwCF with exercise and physical activity has been trialed, albeit with varied success.…”

Section: Exercise In Cystic Fibrosismentioning

confidence: 99%

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Exercise and Airway Clearance Techniques in Cystic Fibrosis

Ward

Stiller

Holland

2022

Semin Respir Crit Care Med

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Exercise and airway clearance techniques (ACTs) have been a cornerstone of treatment for people with cystic fibrosis (pwCF) for many decades. Exercise may confer both respiratory and nonrespiratory benefits for pwCF, with greater exercise capacity associated with improved survival. A wide variety of exercise interventions for pwCF have been investigated. ACTs may assist in reducing respiratory symptoms for pwCF and are currently recommended to be performed daily, with the types of ACTs used varying globally. While recommended components of care, both exercise and ACTs are time-intensive and maintaining adherence to the recommendations over the longer term can be challenging. It has been proposed that with advances in the therapeutic options for pwCF, a rationalization of the therapeutic regimen may be possible. We summarize the current evidence for the use of exercise and ACTs by pwCF, discuss the implications of the introduction of cystic fibrosis transmembrane conductance regulator modulators on both exercise and ACTs, and highlight areas for further research.

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Section: Exercise In Cystic Fibrosismentioning

confidence: 84%

Section: Exercise In Cystic Fibrosismentioning

confidence: 84%

Section: Exercise In Cystic Fibrosismentioning

confidence: 99%

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Exercise and Airway Clearance Techniques in Cystic Fibrosis

Ward

Stiller

Holland

2022

Semin Respir Crit Care Med

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Web-based physical activity promotion in young people with CF: a randomised controlled trial

Cox

Eldridge

Rawlings

et al. 2022

Thorax

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BackgroundPhysical activity levels are known to decline following hospitalisation for people with cystic fibrosis (pwCF). However, optimal physical activity promotion strategies are unclear. This study investigated the effect of a web-based application (ActivOnline) in promoting physical activity in young pwCF.MethodsMulticentre randomised controlled trial with assessor blinding and qualitative evaluation. People with CF (12–35 years) admitted to hospital for a respiratory cause were eligible and randomised to the 12-week ActivOnline intervention (AO) or usual care (UC). The primary outcome was change in device-based time spent in moderate-to-vigorous physical activity (MVPA) from baseline to post-intervention. Follow-up was at 6 months from hospital discharge when qualitative evaluation was undertaken.Results107 participants were randomised to AO (n=52) or UC (n=55). Sixty-three participants (59%) contributed to the intention-to-treat analysis. Mean (SD) age was 21 (6) years (n=46, <18 years). At baseline, physical activity levels were high in both groups (AO 102 (52) vs UC 127 (73) min/day). There was no statistically significant difference in MVPA between groups at either timepoint (post-intervention mean difference (95% CI) −14 mins (−45 to 16)). Uptake of the intervention was low with only 40% (n=21) of participants accessing the web application.ConclusionA web-based application, including individualised goal setting, real-time feedback and motivation for behavioural change, was no better than usual care at promoting physical activity in young pwCF following hospital discharge. High levels of baseline physical activity levels in both groups, and limited engagement with the intervention, suggest alternative strategies may be necessary to identify and support young pwCF who would benefit from enhanced physical activity.Trial registration numberACTRN12617001009303, 13 July 13 2017.

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WS04.6 Effects of a partially supervised conditioning program in cystic fibrosis: an international multi-centre, randomised controlled trial (ACTIVATE-CF)

Cited by 2 publications

References 0 publications

Exercise and Airway Clearance Techniques in Cystic Fibrosis

Exercise and Airway Clearance Techniques in Cystic Fibrosis

Web-based physical activity promotion in young people with CF: a randomised controlled trial

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