WRKY74 regulates cadmium tolerance through glutathione-dependent pathway in wheat

Li, Gezi; Zheng, Yong-Xing; Liu, Haitao; Liu, Jin; Kang, Guozhang

doi:10.1007/s11356-022-20672-6

Cited by 11 publications

(6 citation statements)

References 37 publications

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“…Thus, the improved growth of transgenic Arabidopsis under Cd stress is due to enhanced antioxidant capacity and reduced oxidative damage ( Jia et al., 2021 ). TaWRKY74 consistently mitigates Cd toxicity in wheat by influencing ASA-GSH synthesis genes and repressing Cd transporter genes ( Li et al., 2022 ). In rice, OsWRKY71 significantly induces Cd stress tolerance in leaves, with transcript levels peaking 24 hours post-stress initiation ( Paul and Roychoudhury, 2018 ).…”

Section: Wrky Tfs Regulate Plant CD Stress Responses By Modulating Th...mentioning

confidence: 99%

“…Therefore, TaWRKY70 regulates Cd stress by improving plant antioxidant capacity ( Jia et al., 2021 ). TaWRKY74 affects the absorption and transport of Cd in wheat by affecting the expression of ASA-GSH synthesis genes and inhibiting the expression of Cd transporter genes ( Li et al., 2022 ). In contrast, TaMYC8 activates TaERF6 transcription by binding to the TaERF6 promoter to directly regulate the expression of TaERF6 , thus negatively regulating Cd tolerance ( Wang et al., 2022b ).…”

Section: Mechanisms Underlying Tf Regulation Of Rice and Wheat Respon...mentioning

confidence: 99%

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Transcription factors involved in plant responses to cadmium-induced oxidative stress

Zhang,

2024

Front. Plant Sci.

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Cadmium (Cd) is a heavy metal highly toxic to living organisms. Cd pollution of soils has become a serious problem worldwide, posing a severe threat to crop production and human health. When plants are poisoned by Cd, their growth and development are inhibited, chloroplasts are severely damaged, and respiration and photosynthesis are negatively affected. Therefore, elucidating the molecular mechanisms that underlie Cd tolerance in plants is important. Transcription factors can bind to specific plant cis-acting genes. Transcription factors are frequently reported to be involved in various signaling pathways involved in plant growth and development. Their role in the resistance to environmental stress factors, particularly Cd, should not be underestimated. The roles of several transcription factor families in the regulation of plant resistance to Cd stress have been widely demonstrated. In this review, we summarize the mechanisms of five major transcription factor families–WRKY, ERF, MYB, bHLH, and bZIP–in plant resistance to Cd stress to provide useful information for using molecular techniques to solve Cd pollution problems in the future.

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Section: Wrky Tfs Regulate Plant CD Stress Responses By Modulating Th...mentioning

confidence: 99%

Section: Mechanisms Underlying Tf Regulation Of Rice and Wheat Respon...mentioning

confidence: 99%

Transcription factors involved in plant responses to cadmium-induced oxidative stress

Zhang,

2024

Front. Plant Sci.

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“…According to one study, negatively affected genes include GSH1, GSH2, PCS1, and PCS2 [76]. In Tritucum durum, excessive transcription of TaWRKY74 interferes with the regulating the ascorbate-glutathione (AsA-GSH) cycle genes [77]. Conversely, Arabidopsis thaliana shows positive regulation through the transcription factor MYB75, which impacts the expression of the genes ACBP2 and ABCC2 [78].…”

Section: The Effect Of CD On Gene Expression In Plantsmentioning

confidence: 99%

“…As an example, changes in the expression level of the SaHsfA1a, SaHsfA2a, and SaHsfA4c genes were observed in Sedum alfredii after Cd [83]. It is already known from previous studies that heat-related transcription factors (HSFs) have the capability to influence heavy metals stress-induced genes [77] and there are genes that are also regulated by heat shock. Not only do Cd-treated plants show increased expression but are further enhanced by heat shock [83].…”

Section: The Effect Of CD On Gene Expression In Plantsmentioning

confidence: 99%

The Effect of Cadmium on Plants in Terms of the Response of Gene Expression Level and Activity

Moravčíková

Žiarovská

2023

Plants

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Cadmium (Cd) is a heavy metal that can cause damage to living organisms at different levels. Even at low concentrations, Cd can be toxic to plants, causing harm at multiple levels. As they are unable to move away from areas contaminated by Cd, plants have developed various defence mechanisms to protect themselves. Hyperaccumulators, which can accumulate and detoxify heavy metals more efficiently, are highly valued by scientists studying plant accumulation and detoxification mechanisms, as they provide a promising source of genes for developing plants suitable for phytoremediation techniques. So far, several genes have been identified as being upregulated when plants are exposed to Cd. These genes include genes encoding transcription factors such as iron-regulated transporter-like protein (ZIP), natural resistance associated macrophage protein (NRAMP) gene family, genes encoding phytochelatin synthases (PCs), superoxide dismutase (SOD) genes, heavy metal ATPase (HMA), cation diffusion facilitator gene family (CDF), Cd resistance gene family (PCR), ATP-binding cassette transporter gene family (ABC), the precursor 1-aminocyclopropane-1-carboxylic acid synthase (ACS) and precursor 1-aminocyclopropane-1-carboxylic acid oxidase (ACO) multigene family are also influenced. Thanks to advances in omics sciences and transcriptome analysis, we are gaining more insights into the genes involved in Cd stress response. Recent studies have also shown that Cd can affect the expression of genes related to antioxidant enzymes, hormonal pathways, and energy metabolism.

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“…WRKYs, a group of transcription factors in plants, have been shown to play a crucial role in regulating numerous biotic and abiotic stresses. Recent research conducted on various plants has demonstrated that the WRKYs can enhance Cd tolerance by controlling the expression of downstream target genes [11]. In Arabidopsis, WRKY13 can activate the expression level of PDR8 to positively regulate cadmium tolerance [12].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Profiling, Physiological and Biochemical Analyses Reveal Comprehensive Insights in Cadmium Stress in Brassica carinata L.

Yang,

Pang,

Zhou

et al. 2024

IJMS

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With the constant progress of urbanization and industrialization, cadmium (Cd) has emerged as one of the heavy metals that pollute soil and water. The presence of Cd has a substantial negative impact on the growth and development of both animals and plants. The allotetraploid Brasscia. carinata, an oil crop in the biofuel industry, is known to produce seeds with a high percentage of erucic acid; it is also known for its disease resistance and widespread adaptability. However, there is limited knowledge regarding the tolerance of B. carinata to Cd and its physiological responses and gene expressions under exposure to Cd. Here, we observed that the tested B. carinata exhibited a strong tolerance to Cd (1 mmol/L CdCl2 solution) and exhibited a significant ability to accumulate Cd, particularly in its roots, with concentrations reaching up to 3000 mg/kg. Additionally, we found that the total oil content of B. carinata seeds harvested from the Cd-contaminated soil did not show a significant change, but there were noticeable alterations in certain constituents. The activities of antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX), were observed to significantly increase after treatment with different concentrations of CdCl2 solutions (0.25 mmol/L, 0.5 mmol/L, and 1 mmol/L CdCl2). This suggests that these antioxidant enzymes work together to enhance Cd tolerance. Comparative transcriptome analysis was conducted to identify differentially expressed genes (DEGs) in the shoots and roots of B. carinata when exposed to a 0.25 mmol/L CdCl2 solution for 7 days. A total of 631 DEGs were found in the shoots, while 271 DEGs were found in the roots. It was observed that these selected DEGs, which responded to Cd stress, also showed differential expression after exposure to PbCl2. This suggests that B. carinata may employ a similar molecular mechanism when tolerating these heavy metals. The functional annotation of the DEGs showed enrichment in the categories of ‘inorganic ion transport and metabolism’ and ‘signal transduction mechanisms’. Additionally, the DEGs involved in ‘tryptophan metabolism’ and ‘zeatin biosynthesis’ pathways were found to be upregulated in both the shoots and roots of B. carinata, suggesting that the plant can enhance its tolerance to Cd by promoting the biosynthesis of plant hormones. These results highlight the strong Cd tolerance of B. carinata and its potential use as a Cd accumulator. Overall, our study provides valuable insights into the mechanisms underlying heavy metal tolerance in B. carinata.

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WRKY74 regulates cadmium tolerance through glutathione-dependent pathway in wheat

Cited by 11 publications

References 37 publications

Transcription factors involved in plant responses to cadmium-induced oxidative stress

Transcription factors involved in plant responses to cadmium-induced oxidative stress

The Effect of Cadmium on Plants in Terms of the Response of Gene Expression Level and Activity

Transcriptome Profiling, Physiological and Biochemical Analyses Reveal Comprehensive Insights in Cadmium Stress in Brassica carinata L.

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