Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus

Yabe, Ichiro; Tsuji-Akimoto, Sachiko; Shiga, Tohru; Hamada, Shinsuke; Hirata, Kenji; Otsuki, Mika; Kuge, Yuji; Tamaki, Nagara; Sasaki, Hidenao

doi:10.1016/j.jns.2011.11.039

Cited by 15 publications

(12 citation statements)

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“…Defining the type and degree of language impairment in PD patients is hampered by a lack of generally recognized clinical criteria. The WAB [ 19 ] is an accepted method for assessing language abilities in many neurological diseases including stroke [ 26 , 27 ], amyotrophic lateral sclerosis [ 28 ], corticobasal degeneration syndrome [ 29 ], and brain tumor [ 30 ]. The WAB aphasia quotient (AQ) provides a global measure of aphasia severity [ 31 ] and was found appropriate for assessing non-fluent aphasia [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Characteristics of language impairment in Parkinson’s disease and its influencing factors

Liu

Luo

et al. 2015

Transl Neurodegener

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BackgroundLanguage impairment is relatively common in Parkinson’s disease (PD), but not all PD patients are susceptible to language problems. In this study, we identified among a sample of PD patients those pre-disposed to language impairment, describe their clinical profiles, and consider factors that may precipitate language disability in these patients.MethodsA cross-sectional cohort of 31 PD patients and 20 controls were administered the Chinese version of the Western Aphasia Battery (WAB) to assess language abilities, and the Montreal Cognitive Assessment (MoCA) to determine cognitive status. PD patients were then apportioned to a language-impaired PD (LI-PD) group or a PD group with no language impairment (NLI-PD). Performance on the WAB and MoCA was investigated for correlation with the aphasia quotient deterioration rate (AQDR).ResultsThe PD patients scored significantly lower on most of the WAB subtests than did the controls. The aphasia quotient, cortical quotient, and spontaneous speech and naming subtests of the WAB were significantly different between LI-PD and NLI-PD groups. The AQDR scores significantly and positively correlated with age at onset and motor function deterioration.ConclusionA subset group was susceptible to language dysfunction, a major deficit in spontaneous speech. Once established, dysphasia progression is closely associated with age at onset and motor disability progression.

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Section: Methodsmentioning

confidence: 99%

Characteristics of language impairment in Parkinson’s disease and its influencing factors

Liu

Luo

et al. 2015

Transl Neurodegener

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“…To evaluate whether loss of GABAergic inhibition contributes to cortical hyperexcitability in ALS, PET studies were conducted using the GABA A receptor ligand [ 11 C]-Flumazenil. These studies showed widespread reductions in binding in ALS patients compared to controls (52), and found that reduced binding in the frontal lobes (55) and anterior cingulate gyri (56) in ALS patients correlated with poorer performance on language tasks. Additionally, patients with slowly progressive ALS caused by SOD1 D90A mutations had smaller reductions in binding compared to sporadic ALS patients (53).…”

Section: The Development Of Pet Imaging In Alsmentioning

confidence: 99%

Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis

Chew

Atassi

2019

Front. Neurol.

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with limited treatment options. Despite decades of therapeutic development, only two modestly efficacious disease-modifying drugs—riluzole and edaravone—are available to ALS patients. Biomarkers that can facilitate ALS diagnosis, aid in prognosis, and measure drug pharmacodynamics are needed to accelerate therapeutic development for patients with ALS. Positron emission tomography (PET) imaging has promise as a biomarker for ALS because it permits visualization of central nervous system (CNS) pathology in individuals living with ALS. The availability of PET radioligands that target a variety of potential pathophysiological mechanisms—including cerebral metabolism, neuroinflammation, neuronal dysfunction, and oxidative stress—has enabled dynamic interrogation of molecular changes in ALS, in both natural history studies and human clinical trials. PET imaging has potential as a diagnostic biomarker that can establish upper motor neuron (UMN) pathology in ALS patients without overt UMN symptoms, as a prognostic biomarker that might help stratify patients for clinical trials, and as a pharmacodynamic biomarker that measures the biological effect of investigational drugs in the brain and spinal cord. In this Review, we discuss progress made with 30 years of PET imaging studies in ALS and consider future research needed to establish PET imaging biomarkers for ALS therapeutic development.

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“…Moreover, the WEI was found to be mildly associated with disease duration. Yabe et al . (2012) again found that the WEI [Tsuji-Akimoto et al ., 2010] was able to discriminate ALS patients from HCs, additionally showing that it was related to bilateral right-greater-than-left anterior cingulate cortex (ACC) dysfunction as assessed by positron emission tomography (PET).…”

Section: Resultsmentioning

confidence: 99%

“…EF deficits as contributing to writing errors appears also to be supported as far as neural correlates are concerned – since frontal cortices often appeared to be involved in MND patients showing dysgraphic features [ e . g ., Yabe et al ., 2012].…”

Section: Discussionmentioning

confidence: 99%

Dysgraphic features in motor neuron disease: a review

Aiello

Feroldi

Preti

et al. 2021

Preprint

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BackgroundMotor neuron disease (MND) patients can show oral language deficits mimicking those of frontotemporal degenerations (FTD). Although dysgraphic features have been also reported within the MND-FTD continuum, their characteristics and clinical relevance are still largely unexplored.AimsTo profile writing disorders in MND patients can help further define their cognitive semiology and thus conveys relevant clinical entailments. Therefore, this study aimed at reviewing evidence of writing impairment in MND patients. This review was implemented and reported by consulting Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Qualitative/quantitative measures of writing abilities in MND patients was the primary outcome. Both group studies and case reports/series were taken into consideration. Twenty-four contributions were included out of an initial N=83. Potential biases in generalizing results were qualitatively controlled for by extracting background, disease-related, neuropsychological and neuroanatomofunctional secondary outcomes.Main ContributionFifteen studies assessed writing abilities in Japaneses patients, whereas the remaining eight in western patients. Central dysgraphic features were reported in both neuropsychologically-impaired and –unimpaired MND patients. Phonetic/phonological paragraphias and morpho-syntactic errors were frequently reported. Although FTD was frequently co-occurent, neither cognitive nor language impairment fully accounted for writing impairment in some patients. By contrast, evidence of peripheral dysgraphia was scarce. Patients displaying writing deficits often presented with bulbar signs and perisylvian cortices involvement (including Exner’s area and the left angular gyrus). Writing deficits proved to be associated with abnormalities in executive functioning and its neural substrates. Writing-to-dictation tasks as well as writing samples assessment proved to be useful to detect writing errors.ConclusionsDysgraphic features in MND patients might be due to dysfunctions of the graphemic buffer – and possibly the phonological route. The lexico-semantic route appeared to be less involved. However, a mixed peripheral/central involvement cannot be ruled out. In this population, executive/attentive deficits are likely to contribute to writing errors as well. Writing deficits might thus be specific of MND patients’ cognitive/language impairment profile. The evaluation of writing abilities via writing-to-dictation/narrative writing tasks may be useful when assessing cognition/language in both neuropsychological-impaired and -unimpaired MND patients - especially when severe dysarthria/anarthria is present and prevents clinicians from assessing oral language.

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Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus

Abstract: showed that writing errors in our patients with ALS were related to dysfunction in the anterior cingulate gyrus.

Cited by 15 publications

References 34 publications

Characteristics of language impairment in Parkinson’s disease and its influencing factors

Characteristics of language impairment in Parkinson’s disease and its influencing factors

Positron Emission Tomography Molecular Imaging Biomarkers for Amyotrophic Lateral Sclerosis

Dysgraphic features in motor neuron disease: a review

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