Writing emails as part of sleepwalking after increase in Zolpidem

Siddiqui, Fouzia; Osuna, Edgar; Chokroverty, Sudhansu

doi:10.1016/j.sleep.2008.09.008

Cited by 41 publications

(5 citation statements)

References 2 publications

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“…These complex behaviors included driving a car, cleaning the house, writing a e-mail with inputing correct user name and password to log on, engaging in conversation and sex. 18 , 19) Especially, these complex behaviors resulted in car accidents or crime such as violence and sex offense, 2) although cause and effect was not always clear.…”

Section: Discussionmentioning

confidence: 99%

Zolpidem Induced Sleep-related Eating and Complex Behaviors in a Patient with Obstructive Sleep Apnea and Restless Legs Syndrome

Park

Shin

2016

Clin Psychopharmacol Neurosci

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Zolpidem-induced sleep-related complex behaviors (SRCB) with anterograde amnesia have been reported. We describe herein a case in which the development of zolpidem-induced sleep-related eating disorder (SRED) and SRCB was strongly suspected. A 71-year-old Korean male was admitted to the Department of Psychiatry due to his repetitive SRED and SRCB with anterograde amnesia, which he reported as having occurred since taking zolpidem. The patient also had restless legs syndrome (RLS) and obstructive sleep apnea (OSA). His baseline serum iron level was low at admission. Zolpidem discontinuation resulted in the immediate disappearance of his SRED, but did not affect his RLS symptoms. These symptoms rapidly improved after adding a single i.v. iron injection once daily, and so he was discharged to day-clinic treatment. These findings indicate that zolpidem can induce SRCB. Although the pathophysiology of zolpidem-induced SRED and other SRCB remains unclear, clinicians should carefully monitor for the potential induction of complex behaviors associated with zolpidem in patients with comorbid RLS or OSA.

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Section: Discussionmentioning

confidence: 99%

Zolpidem Induced Sleep-related Eating and Complex Behaviors in a Patient with Obstructive Sleep Apnea and Restless Legs Syndrome

Park

Shin

2016

Clin Psychopharmacol Neurosci

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“…As noted earlier, there have been concerns about reports of atypical, dissociative behaviors occurring among patients after consuming zolpidem (4)(5)(6)(7)(8)(9)(10)(11). Evidence for such sequelae of zolpidem ingestion was seen here.…”

Section: Discussionmentioning

confidence: 99%

“…While believed to be a safer alternative to benzodiazepines for the treatment of insomnia, having lower risks for both toxicity and dependence (3,4), numerous instances of adverse events after administration have been reported. These include bizarre dissociative behaviors such as sleep driving, anterograde amnesia, hallucinations (including self-harm command hallucinations), and suicide (4)(5)(6)(7)(8)(9)(10)(11). Despite its lower risk of toxicity, cases of accidental and deliberate zolpidem poisoning have been reported (12)(13)(14)(15)(16)(17).…”

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confidence: 99%

Toxicology and Characteristics of Deaths Involving Zolpidem in New South Wales, Australia 2001–2010*

Darke

Deady

Duflou

2012

Journal of Forensic Sciences

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: All cases presenting to the New South Wales Department of Forensic Medicine between January 1, 2001 and September 31, 2010 in which zolpidem was detected, were retrieved. A total of 91 cases were identified. The mean age was 49.4 years, 65.9% were male, and 61.5% were suicides. Zolpidem was a factor contributing to death in 35 (37.3%) cases, of which 31 (34.1%) involved zolpidem toxicity. The median blood zolpidem concentration was 0.20 mg/L (range 0.05–3.50 mg/L), with no significant gender difference. Drug toxicity cases involving zolpidem had significantly higher median blood zolpidem concentrations than other cases (0.50 vs. 0.10 mg/L). In 83.5% of cases, psychoactive substances other than zolpidem were detected, most commonly antidepressants (46.2%), benzodiazepines (35.2%), opioids (26.4%), and alcohol (39.6%). In summary, zolpidem was a factor contributing to death in a large proportion of cases, predominately involving drug toxicity and suicide.

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“…Since then, several more reports have been described in the literature. 30,31 Although post-marketing studies reported low incidences of sleepwalking (0.3e1%), 31 they can be dangerous to patients. 32,33 The incidence reported in Taiwan is considerably higher (5.1%) 20 as shown in one retrospective study listed in Table 2.…”

Section: Sleepwalkingmentioning

confidence: 99%

Complex Behaviors Related to Zolpidem: An Analysis of Published Clinical Cases from Taiwan

Wu-Chou

Shen

2012

Journal of Experimental & Clinical Medicine

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Writing emails as part of sleepwalking after increase in Zolpidem

Cited by 41 publications

References 2 publications

Zolpidem Induced Sleep-related Eating and Complex Behaviors in a Patient with Obstructive Sleep Apnea and Restless Legs Syndrome

Zolpidem Induced Sleep-related Eating and Complex Behaviors in a Patient with Obstructive Sleep Apnea and Restless Legs Syndrome

Toxicology and Characteristics of Deaths Involving Zolpidem in New South Wales, Australia 2001–2010*

Complex Behaviors Related to Zolpidem: An Analysis of Published Clinical Cases from Taiwan

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