Wrist Proprioception in Adults with and without Subacute Stroke

Young, Brittany M.; Yadav, Rishika; Rana, Shivam; Kim, Won‐Seok; Liu, Camellia; Batth, Rajan; Sakthi, Shivani; Farahmand, Eden; Han, Simon; Patel, Darshan P.; Luo, Jason; Ramsey, Christina; Feldman, Marc; Cardoso-Ferreira, Isabel; Holl, Christina; Nguyen, Tiffany; Brinkman, Lorie; Su, Meiying; Chang, Tracy Y.; Cramer, Steven C.

doi:10.3390/brainsci13010031

Cited by 7 publications

(6 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the comparison, the frequency distributions of discrimination of limb position, tested using the WPST, showed a low proportion with extreme position discrimination impairment, which is consistent with recent studies from other groups [ 5 ]. Proprioception is associated with brain activation in high-order sensorimotor cortices, including the right supramarginal gyrus, in healthy and stroke-affected participants [ 51 , 52 ], and persistent impairment is associated with damage to such regions [ 53 ].…”

Section: Discussionsupporting

confidence: 89%

“…Somatosensation includes different modalities, such as touch and proprioception, as well as the processing and recognition of fused information across somatosensory modalities, such as with haptic object recognition [ 1 , 2 ]. As clinicians and scientists, we frequently encounter people who experience disruption to one or more somatosensory modalities, such as following a stroke [ 3 , 4 , 5 ]. A challenge in advancing our understanding for clinicians, researchers and survivors of stroke alike is being able to answer questions such as: what is the extent of disruption to one or more modalities, and is the nature and severity of impairment comparable across modalities?…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Calibration of Impairment Severity to Enable Comparison across Somatosensory Domains

et al. 2023

View full text Add to dashboard Cite

Comparison across somatosensory domains, important for clinical and scientific goals, requires prior calibration of impairment severity. Provided test score distributions are comparable across domains, valid comparisons of impairment can be made by reference to score locations in the corresponding distributions (percentile rank or standardized scores). However, this is often not the case. Test score distributions for tactile texture discrimination (n = 174), wrist joint proprioception (n = 112), and haptic object identification (n = 98) obtained from pooled samples of stroke survivors in rehabilitation settings were investigated. The distributions showed substantially different forms, undermining comparative calibration via percentile rank or standardized scores. An alternative approach is to establish comparable locations in the psychophysical score ranges spanning performance from just noticeably impaired to maximally impaired. Several simulation studies and a theoretical analysis were conducted to establish the score distributions expected from completely insensate responders for each domain. Estimates of extreme impairment values suggested by theory, simulation and observed samples were consistent. Using these estimates and previously discovered values for impairment thresholds in each test domain, comparable ranges of impairment from just noticeable to extreme impairment were found. These ranges enable the normalization of the three test scales for comparison in clinical and research settings.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Calibration of Impairment Severity to Enable Comparison across Somatosensory Domains

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Treatment should be initiated in the post-acute phase, last for at least 2 weeks, and its efficacy assessed with a primary outcome measure of tactile and proprioceptive functions of somatosensation. 92 , 93 Further, for optimal clinical effect, mGluR5 NAMs should be combined with relevant rehabilitative training paradigms. 28 , 75 …”

Section: Discussionmentioning

confidence: 99%

Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity

Hakon,

Quattromani,

Sjölund

et al. 2023

Brain

View full text Add to dashboard Cite

Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischemic stroke, there is no clinically-approved pharmacological treatment that alleviates sensorimotor impairments. Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connections. The type-5 metabotropic glutamate receptor (mGluR5) has been shown to modulate brain plasticity and function, and is a therapeutic target in neurological diseases outside of stroke. We investigated whether mGluR5 influences functional recovery and network reorganization rodent models of focal ischemia. Using multiple behavioral tests we observed that treatment with negative allosteric modulators (NAMs) of mGluR5 (MTEP, fenobam, and AFQ056) for 12 days, starting 2 or 10 days after stroke, restored lost sensorimotor functions, without diminishing infarct size. Recovery was evident within hours after initiation of treatment and progressed over the subsequent 12 days. Recovery was prevented by activation of mGluR5 with the positive allosteric modulator VU0360172, and accelerated in mGluR5 KO mice compared to wild-type mice. After stroke, multisensory stimulation by enriched environments (EE) enhanced recovery, a result prevented by VU0360172, implying a role of mGluR5 in EE-mediated recovery. Additionally, MTEP treatment in conjunction with EE housing provided an additive recovery enhancement compared to either MTEP or EE alone. Using optical intrinsic signal imaging, we observed brain-wide disruptions in resting-state functional connectivity after stroke that were prevented by mGluR5 inhibition in distinct areas of contralesional sensorimotor and bilateral visual cortices. The levels of mGluR5 protein in mice and in tissue samples of stroke patients were unchanged after stroke. We conclude that neuronal circuitry subserving sensorimotor function after stroke is depressed by a mGluR5-dependent maladaptive plasticity mechanism that can be restored by mGluR5 inhibition. Post-acute stroke treatment with mGluR5 NAMs combined with rehabilitative training may represent a novel post-acute stroke therapy.

show abstract

“…To date, a variety of techniques have been employed to identify deficits in position sense and kinesthesia of the wrist [ 2 , 15 ] or the limb [ 4 , 6 , 16 – 23 ]. Here, the experimenter or device passively moves the participant’s hand or limb to a pre-determined location.…”

Section: Introductionmentioning

confidence: 99%

Impaired proprioception and magnified scaling of proprioceptive error responses in chronic stroke

Tulimieri,

Semrau

2024

J NeuroEngineering Rehabil

View full text Add to dashboard Cite

Background Previous work has shown that ~ 50–60% of individuals have impaired proprioception after stroke. Typically, these studies have identified proprioceptive impairments using a narrow range of reference movements. While this has been important for identifying the prevalence of proprioceptive impairments, it is unknown whether these error responses are consistent for a broad range of reference movements. The objective of this study was to characterize proprioceptive accuracy as function of movement speed and distance in stroke. Methods Stroke (N = 25) and controls (N = 21) completed a robotic proprioception test that varied movement speed and distance. Participants mirror-matched various reference movement speeds (0.1–0.4 m/s) and distances (7.5–17.5 cm). Spatial and temporal parameters known to quantify proprioception were used to determine group differences in proprioceptive accuracy, and whether patterns of proprioceptive error were consistent across testing conditions within and across groups. Results Overall, we found that stroke participants had impaired proprioception compared to controls. Proprioceptive errors related to tested reference movement scaled similarly to controls, but some errors showed amplified scaling (e.g., significantly overshooting or undershooting reference speed). Further, interaction effects were present for speed and distance reference combinations at the extremes of the testing distribution. Conclusions We found that stroke participants have impaired proprioception and that some proprioceptive errors were dependent on characteristics of the movement (e.g., speed) and that reference movements at the extremes of the testing distribution resulted in significantly larger proprioceptive errors for the stroke group. Understanding how sensory information is utilized across a broad spectrum of movements after stroke may aid design of rehabilitation programs.

show abstract

Wrist Proprioception in Adults with and without Subacute Stroke

Cited by 7 publications

References 50 publications

Calibration of Impairment Severity to Enable Comparison across Somatosensory Domains

Calibration of Impairment Severity to Enable Comparison across Somatosensory Domains

Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity

Impaired proprioception and magnified scaling of proprioceptive error responses in chronic stroke

Contact Info

Product

Resources

About