WOX5 is Shining in the Root Stem Cell Niche

Kong, Xiangpei; Lu, Songchong; Tian, Huiyu; Ding, Zhaojun

doi:10.1016/j.tplants.2015.08.009

Cited by 49 publications

(34 citation statements)

References 12 publications

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“…In the QC, WOX5 acts in a manner similar to that of its homolog WUS in the OC of SAM. It is involved in the regulation of QC and root distal stem cell identity (Sakamoto et al 2006;Sarkar et al 2007;Forzani et al 2014;Su et al 2014;Kong et al 2015). WOX5 acts downstream of auxin signalling, which requires the transcriptional repressor AXR3/IAA17 as well as the ARF10 and ARF16 transcription factors (Ding & Friml 2010).…”

Section: Root Apical Meristemmentioning

confidence: 99%

Redox regulation at the site of primary growth: auxin, cytokinin and ROS crosstalk

Tognetti

Bielach

Hrtyan

2017

Plant Cell & Environment

107

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To maintain the activity of meristems is an absolute requirement for plant growth and development, and the role of the plant hormones auxin and cytokinin in apical meristem function is well established. Only little attention has been given, however, to the function of the reactive oxygen species (ROS) gradient along meristematic tissues and its interplay with hormonal regulatory networks. The interdependency between auxin-related, cytokinin-related and ROS-related circuits controls primary growth and development while modulating plant morphology in response to detrimental environmental factors. Because ROS interaction with redoxactive compounds significantly affects the cellular redox gradient, the latter constitutes an interface for crosstalk between hormone and ROS signalling pathways. This review focuses on the mechanisms underlying ROS-dependent interactions with redox and hormonal components in shoot and root apical meristems which are crucial for meristems maintenance when plants are exposed to environmental hardships. We also emphasize the importance of cell type and the subcellular compartmentalization of ROS and redox networks to obtain a holistic understanding of how apical meristems adapt to stress.

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Section: Root Apical Meristemmentioning

confidence: 99%

Redox regulation at the site of primary growth: auxin, cytokinin and ROS crosstalk

Tognetti

Bielach

Hrtyan

2017

Plant Cell & Environment

107

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“…In the Arabidopsis thaliana root, a small group of mitotically hypoactive cells, referred to as the quiescent center (QC), separates the population of stem cells into two distinct domains and prevents any differentiation of the surrounding stem cells (van den Berg et al, 1997;Heyman et al, 2014). Maintenance of the root SCN in A. thaliana requires the activity of the homeobox transcription factor WOX5, which is specifically transcribed in the QC and maintains the identity of both the QC and the distal stem cells (DSCs) (Sarkar et al, 2007;Kong et al, 2015). WOX5 inhibits cell division in the QC by suppressing CYCD3;3, and it moves from the QC into the DSCs (Forzani et al, 2014) where it represses the differentiation factor CDF4 to inhibit root DSC differentiation via recruiting TPL/TPR co-repressors and the histone deacetylase HDA19 (Pi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis

et al. 2018

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The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root stem cell niche identity by both inhibiting proliferative processes in the QC and stimulating cell division in the proximal meristem (PM). PHB3 coordinates cell division and differentiation in the root apical meristem by restricting the spatial expression of ethylene response factor (ERF) transcription factors 115, 114, and 109. ERF115, ERF114, and ERF109 mediate ROS signaling, in a PLT-independent manner, to control root stem cell niche maintenance and root growth through phytosulfokine (PSK) peptide hormones in Arabidopsis.

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“…The PRESSED FLOWER1 (PRS1/AtWOX3) protein is involved in the initiation and development of lateral organs, as it recruits founder cells from all meristem layers in Arabidopsis [11]. As a homolog of AtWUS, AtWOX5 is specifically expressed in the quiescent center of the root and is essential for stem cell maintenance in the RAM via a negative feedback signal provided by CLE40 [12]. The PRETTY FEW SEEDS2 (PFS2/AtWOX6) protein is abundantly expressed in developing ovules and plays a key role during ovule patterning by regulating both cell proliferation of the maternal integuments and differentiation of the megaspore mother cell [13].…”

Section: Introductionmentioning

confidence: 99%

Identification of the WUSCHEL-Related Homeobox (WOX) Gene Family, and Interaction and Functional Analysis of TaWOX9 and TaWUS in Wheat

Liú

Xia

et al. 2020

IJMS

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The WUSCHEL-related homeobox (WOX) is a family of plant-specific transcription factors, with important functions, such as regulating the dynamic balance of division and differentiation of plant stem cells and plant organ development. We identified 14 distinct TaWOX genes in the wheat (Triticum aestivum L.) genome, based on a genome-wide scan approach. All of the genes under evaluation had positional homoeologs on subgenomes A, B and D except TaWUS and TaWOX14. Both TaWOX14a and TaWOX14d had a paralogous copy on the same genome due to tandem duplication events. A phylogenetic analysis revealed that TaWOX genes could be divided into three groups. We performed functional characterization of TaWOX genes based on the evolutionary relationships among the WOX gene families of wheat, rice (Oryza sativa L.), and Arabidopsis. An overexpression analysis of TaWUS in Arabidopsis revealed that it affected the development of outer floral whorl organs. The overexpression analysis of TaWOX9 in Arabidopsis revealed that it promoted the root development. In addition, we identified some interaction between the TaWUS and TaWOX9 proteins by screening wheat cDNA expression libraries, which informed directions for further research to determine the functions of TaWUS and TaWOX9. This study represents the first comprehensive data on members of the WOX gene family in wheat.

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WOX5 is Shining in the Root Stem Cell Niche

Cited by 49 publications

References 12 publications

Redox regulation at the site of primary growth: auxin, cytokinin and ROS crosstalk

Redox regulation at the site of primary growth: auxin, cytokinin and ROS crosstalk

PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis

Identification of the WUSCHEL-Related Homeobox (WOX) Gene Family, and Interaction and Functional Analysis of TaWOX9 and TaWUS in Wheat

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