Wound repair, remodeling, and regeneration

Bando, Toshikazu; Yokoyama, Hitoshi; Nakamura, Harukazu

doi:10.1111/dgd.12566

Cited by 12 publications

(6 citation statements)

References 16 publications

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“…Hypertrophic scars are generated after traumas or surgery interventions and regress in a few months. On the other hand, in people with specific genetic predispositions, injuries can promote the formation of keloids, which are structures that are unable to be spontaneously reabsorbed [ 85 ].…”

Section: Tissue Regeneration and Emtmentioning

confidence: 99%

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Marconi

Fonticoli

Rajan

et al. 2021

Cells

183

144

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The epithelial–mesenchymal transition (EMT) is an essential event during cell development, in which epithelial cells acquire mesenchymal fibroblast-like features including reduced intercellular adhesion and increased motility. EMT also plays a key role in wound healing processes, which are mediated by inflammatory cells and fibroblasts. These cells secrete specific factors that interact with molecules of the extracellular matrix (ECM) such as collagens, laminins, elastin and tenascins. Wound healing follows four distinct and successive phases characterized by haemostasis, inflammation, cell proliferation and finally tissue remodeling. EMT is classified into three diverse subtypes: type-1 EMT, type-2 EMT and type-3 EMT. Type-1 EMT is involved in embryogenesis and organ development. Type-2 EMT is associated with wound healing, tissue regeneration and organ fibrosis. During organ fibrosis, type-2 EMT occurs as a reparative-associated process in response to ongoing inflammation and eventually leads to organ destruction. Type-3 EMT is implicated in cancer progression, which is linked to the occurrence of genetic and epigenetic alterations, in detail the ones promoting clonal outgrowth and the formation of localized tumors. The current review aimed at exploring the role of EMT process with particular focus on type-2 EMT in wound healing, fibrosis and tissue regeneration, as well as some recent progresses in the EMT and tissue regeneration field, including the modulation of EMT by biomaterials.

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Section: Tissue Regeneration and Emtmentioning

confidence: 99%

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Marconi

Fonticoli

Rajan

et al. 2021

Cells

183

144

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“…[ 172 ] Furthermore, smart hydrogel dressings can reduce wound temperature and pressure caused by wound vasodilation on peripheral nerve fibers, thereby alleviating pain in patients. [ 173 ] Considering their properties, smart hydrogels are regarded as one of the most promising options for application as wound dressings.…”

Section: Smart Hydrogel Applicationsmentioning

confidence: 99%

Smart Hydrogels for Tissue Regeneration

Xie,

Xu,

Wang

et al. 2023

Macromolecular Bioscience

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The rapid growth in the portion of the aging population has led to a consequent increase in demand for biomedical hydrogels, together with an assortment of challenges that need to be overcome in this field. Smart hydrogels can autonomously sense and respond to the physiological/pathological changes of the tissue microenvironment and continuously adapt the response according to the dynamic spatiotemporal shifts in conditions. This along with other favorable properties, make smart hydrogels excellent materials for employing toward improving the precision of treatment for age‐related diseases. The key factor during the design of smart hydrogels is on accurately identifying the characteristics of natural tissues and faithfully replicating the composition, structure, and biological functions of these tissues at the molecular level. Such hydrogels can accurately sense distinct physiological and external factors such as temperature and pH, biologically active molecules, mechanical signals, and other stimuli, so they may in turn actively and promptly adjust their response, by regulating their own biological effects, thereby promoting damaged tissue repair. This review summarizes the design strategies employed in the creation of smart hydrogels, their response mechanisms, as well as their applications in field of tissue engineering; and concludes by briefly discussing the relevant challenges and future prospects.This article is protected by copyright. All rights reserved

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“…The coagulation cascade forms a fibrin matrix rich in cytokines and growth factors through platelet aggregation and blood coagulation provides scaffolds for subsequent infiltrating cells (leukocytes, keratinocytes, fibroblasts, endothelial cells, etc.) (Gurtner et al, 2008;Minutti et al, 2017;Bando et al, 2018;Criscitelli, 2018). Then, immune cells migrate to the wound under the influence of chemokines and release a large number of cytokines to initiate the inflammatory response (Bando et al, 2018;Akita, 2019), neutrophils are first recruited to the wound and reach a peak within 24 h (Kim et al, 2008), by changing the phenotype and expression of macrophages to generate the innate immune response (Park and Barbul, 2004;Acosta et al, 2008;Suga et al, 2014).…”

Section: Continuous Activation Of Innate Immunity Hidden Under Immune-aging and Inflamm-aging Hinders Diabetic Wound Healingmentioning

confidence: 99%

“…(Gurtner et al, 2008;Minutti et al, 2017;Bando et al, 2018;Criscitelli, 2018). Then, immune cells migrate to the wound under the influence of chemokines and release a large number of cytokines to initiate the inflammatory response (Bando et al, 2018;Akita, 2019), neutrophils are first recruited to the wound and reach a peak within 24 h (Kim et al, 2008), by changing the phenotype and expression of macrophages to generate the innate immune response (Park and Barbul, 2004;Acosta et al, 2008;Suga et al, 2014). Subsequently, monocytes are recruited in the wound within 48-96 h after injury and differentiate into macrophages, carry out the function of engulfing pathogens and cellular debris, promote the secretion of cytokines, growth factors, and chemokines, stimulate collagen synthesis and angiogenesis, promote the conversion of fibroblasts to myofibroblasts to fill and contract the wound, and provide supports for subsequent cell proliferation, migration, and reepithelialization (Snyder et al, 2016;Kim and Nair, 2019).…”

Section: Continuous Activation Of Innate Immunity Hidden Under Immune-aging and Inflamm-aging Hinders Diabetic Wound Healingmentioning

confidence: 99%

Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory

Geng

Jiang³

et al. 2021

Front. Pharmacol.

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A growing body of evidence suggests that the interaction between immune and metabolic responses is essential for maintaining tissue and organ homeostasis. These interacting disorders contribute to the development of chronic diseases associated with immune-aging such as diabetes, obesity, atherosclerosis, and nonalcoholic fatty liver disease. In Diabetic wound (DW), innate immune cells respond to the Pathogen-associated molecular patterns (PAMAs) and/or Damage-associated molecular patterns (DAMPs), changes from resting to an active phenotype, and play an important role in the triggering and maintenance of inflammation. Furthermore, the abnormal activation of innate immune pathways secondary to immune-aging also plays a key role in DW healing. Here, we review studies of innate immune cellular molecular events that identify metabolic disorders in the local microenvironment of DW and provide a historical perspective. At the same time, we describe some of the recent progress, such as TLR receptor-mediated intracellular signaling pathways that lead to the activation of NF-κB and the production of various pro-inflammatory mediators, NLRP3 inflammatory via pyroptosis, induction of IL-1β and IL-18, cGAS-STING responds to mitochondrial injury and endoplasmic reticulum stress, links sensing of metabolic stress to activation of pro-inflammatory cascades. Besides, JAK-STAT is also involved in DW healing by mediating the action of various innate immune effectors. Finally, we discuss the great potential of targeting these innate immune pathways and reprogramming innate immune cell phenotypes in DW therapy.

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Wound repair, remodeling, and regeneration

Cited by 12 publications

References 16 publications

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis

Smart Hydrogels for Tissue Regeneration

Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory

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