Wound management in a patient with rhinophyma and basal cell carcinoma

Kwah, Raymond Y.C.; Lawrence, C.M.

doi:10.1016/j.jaad.2011.01.021

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…16, 17 WNT/β-catenin signaling in melanoma tumors has previously been shown to correlate with improved survival in patients, which was corroborated by murine xenograft models where melanoma cells overexpressing WNT3A exhibit reduced tumor volumes and metastasis compared with parental cells. 15 Furthermore, reduced β-catenin expression has been associated with progression of melanoma in additional clinical cohorts.…”

Section: Introductionmentioning

confidence: 68%

WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner

et al. 2017

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Aberrant regulation of WNT/β-catenin signaling has a crucial role in the onset and progression of cancers, where the effects are not always predictable depending on tumor context. In melanoma, for example, models of the disease predict differing effects of the WNT/β-catenin pathway on metastatic progression. Understanding the processes that underpin the highly context-dependent nature of WNT/β-catenin signaling in tumors is essential to achieve maximal therapeutic benefit from WNT inhibitory compounds. In this study, we have found that expression of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), alters the invasive potential of melanoma cells in response to WNT/β-catenin signaling, correlating with differing metabolic profiles. This alters the bioenergetic potential and mitochondrial activity of melanoma cells, triggered through regulation of pro-survival autophagy. Thus, WNT/β-catenin signaling is a regulator of catabolic processes in cancer cells, which varies depending on the metabolic requirements of tumors.

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Section: Introductionmentioning

confidence: 68%