Wound management and dressings

Ather, S.; Harding, Keith; Tate, Sophia

doi:10.1016/b978-0-08-102192-7.00001-1

Cited by 17 publications

(17 citation statements)

References 41 publications

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“…PDGF and TGF-β initiate chemotaxis of neutrophils, macrophages, fibroblasts, and smooth muscle cells. These processes are required for the wound healing cascade to progress to the next stage, inflammation [ 77 , 90 , 91 ].…”

Section: Clotting and Coagulation (Hemostasis)mentioning

confidence: 99%

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

2022

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The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins. Studies have demonstrated the ECM aids in cellular adherence, tissue anchoring, cellular signaling, and recruitment of cells. During times of integumentary injury or damage, either acute or chronic, the ECM is damaged. Through a series of overlapping events called the wound healing phases—hemostasis, inflammation, proliferation, and remodeling—the ECM is synthesized and ideally returned to its native state. This article synthesizes current and historical literature to demonstrate the involvement of the ECM in the varying phases of the wound healing cascade.

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Section: Clotting and Coagulation (Hemostasis)mentioning

confidence: 99%

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

2022

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“…The mechanism study and conclusion also provide insights into the design and fabrication of future antimicrobial materials that delay or prevent the development of resistance. Specifically, we developed these particles for use in wound care since the infection of chronic wounds is a significant and pressing challenge and the antioxidant and anti-inflammatory effects of selenium-based NPs are also very beneficial for wound healing. , However, these particles likely have a variety of other potential applications such as in anti-infective coatings on implantable devices.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Huang

Holden

Reynolds

et al. 2020

ACS Appl. Mater. Interfaces

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Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization’s Global Antimicrobial Surveillance System has revealed widespread occurrence of antibiotic resistance among half a million patients across 22 countries, with Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae being the most common resistant species. Antimicrobial nanoparticles are emerging as a promising alternative to antibiotics in the fight against antimicrobial resistance. In this work, selenium nanoparticles coated with the antimicrobial polypeptide, ε-poly-l-lysine, (Se NP-ε-PL) were synthesized and their antibacterial activity and cytotoxicity were investigated. Se NP-ε-PL exhibited significantly greater antibacterial activity against all eight bacterial species tested, including Gram-positive, Gram-negative, and drug-resistant strains, than their individual components, Se NP and ε-PL. The nanoparticles showed no toxicity toward human dermal fibroblasts at the minimum inhibitory concentrations, demonstrating a therapeutic window. Furthermore, unlike the conventional antibiotic kanamycin, Se NP-ε-PL did not readily induce resistance in E. coli or S. aureus. Specifically, S. aureus began to develop resistance to kanamycin from ∼44 generations, whereas it took ∼132 generations for resistance to develop to Se NP-ε-PL. Startlingly, E. coli was not able to develop resistance to the nanoparticles over ∼300 generations. These results indicate that the multifunctional approach of combining Se NP with ε-PL to form Se NP-ε-PL is a highly efficacious new strategy with wide-spectrum antibacterial activity, low cytotoxicity, and significant delays in development of resistance.

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“…Wounds are defined as skin deformities or tissue discontinuities brought about by physical or thermal injury, or underlying ailments [ 35 ]. Given the nature and duration of the healing process, wounds are usually divided into acute and chronic types [ 36 ].…”

Section: Wound and Wound Dressingmentioning

confidence: 99%

Electrospun Medicated Nanofibers for Wound Healing: Review

et al. 2021

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With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers’ attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

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Wound management and dressings

Cited by 17 publications

References 41 publications

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Electrospun Medicated Nanofibers for Wound Healing: Review

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