Wound healing related agents: Ongoing research and perspectives

Kaplani, Konstantina; Koutsi, Stamatina; Armenis, Vasileios; Skondra, Foteini G.; Karantzelis, Nikolaos; Tsaniras, Spyridon Champeris; Taraviras, Stavros

doi:10.1016/j.addr.2018.02.007

Cited by 73 publications

(51 citation statements)

References 141 publications

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“…In particular, VEGF is present at elevated levels during the first phases of wound repair, but its expression declines as the healing process is completed. Angiogenic therapy may have a positive effect in the formation of granulation tissue through collagen deposition, epithelialization, and capillary growth . Our previous study has showed that optimal session of ESWT significantly enhance diabetic wound healing associated with increasing neo‐angiogenesis, tissue regeneration, and topical anti‐inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

“…Wound healing processes have been reported to be regulated by a multitude of cytokines and growth factors, including epidermal growth factor, transforming growth factor‐β, hepatocyte growth factor, vascular endothelial growth factor (VEGF), fibroblast growth factor, keratinocyte growth factor, interleukin family, and tumor necrosis factor‐α . In particular, VEGF is present at elevated levels during the first phases of wound repair, but its expression declines as the healing process is completed . VEGF is considered as the key regulator of both vascular development and physiological and pathological angiogenesis during inflammation and wound healing .…”

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confidence: 99%

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Modulation of vascular endothelial growth factor and mitogen‐activated protein kinase‐related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing

Chen

Chang

Wang

et al. 2018

Wound Repair Regeneration

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Extracorporeal shockwave therapy (ESWT) has a significant positive effect to accelerate chronic wound healing. This study investigated whether the vascular endothelial growth factor (VEGF)–related pathway has involved in ESWT enhancement of diabetic wound healing. A dorsal skin defect (area, 6 × 5 cm) in a streptozotocin‐induced diabetes rodent model was used. Thirty‐two male Wistar rats were divided into four groups. Group I consisted of nondiabetic control; group II, diabetic control without treatment; group III, diabetic rats received ESWT; and group IV, rats received Avastin (a VEGF monoclonal antibody) on day 0 (post‐wounding immediately) to day 7 and ESWT on day 3 and day 7. The wound healing was assessed clinically. The VEGF, endothelial nitric oxide synthase (eNOS), and Ki‐67 were analyzed with immunohistochemical staining. The mRNA expression of mitogen‐activated protein kinase–related genes was measured by real‐time quantitative real‐time polymerase chain reaction. The results revealed wound size was significantly reduced in the ESWT‐treated rats as compared to the diabetic control (p < 0.01). The positive effect of ESWT‐increasing wound healing was significantly suppressed in pretreatment of the Avastin group. Histological findings revealed significant increase in neo‐vessels in the ESWT group as compared to the control. In immunohistochemical stain, significant increases in VEGF, eNOS, and Ki‐67 expressions were noted in the ESWT group as compared to that in controls. However, Avastin suppressed the shockwave effect and down‐regulation of VEGF, eNOS, and Ki‐67 expressions in the Avastin‐ESWT group as compared to that in the ESWT alone group. We found that highly mRNA expression of Kras, Raf1, Mek1, Jnkk, Jnk, and Jun at early stage in the ESWT group, as compared to the diabetic control. These evidences indicated treatment with multiple sessions of ESWT significantly enhanced diabetic wound healing associated with increased neovascularization and tissue regeneration. The bio‐mechanism of ESWT‐enhanced wound healing is correlated with VEGF and mitogen‐activated protein kinase–mediated pathway.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Modulation of vascular endothelial growth factor and mitogen‐activated protein kinase‐related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing

Chen

Chang

Wang

et al. 2018

Wound Repair Regeneration

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“…La piel se encuentra expuesta a múltiples agresiones que la hacen propensa a heridas, las cuales al cicatrizar de una manera inadecuada pueden producir morbilidades, incapacidades motoras o alteraciones estéticas que afectan la vida diaria de las personas que las padecen (Kaplani et al, 2018).…”

Section: Introductionunclassified

Caracterización Biomolecular Mediante Microespectroscopía FTIR en la Fase de Remodelación de la Cicatrización en un Modelo Murino de Lesión Excisional

Vázquez-Zapién

Mata-Miranda²,

García-Sánchez

et al. 2019

Int. J. Morphol.

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“…In most of the cases, the healing process is interrupted during the inflammation phase. Although the aetiology is highly variable, persistent infection, biofilm formation and reduction of granulation and reepithelialisation are common characteristics associated with non-healing wounds (3,4). High incidence of chronic wounds accompanied by increasing bacterial resistance justifies enlarged interest in the development of nonconventional, more efficient therapies.…”

mentioning

confidence: 99%

Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres

et al. 2019

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The aim of this study was to evaluate long-term stability and assess the wound healing potential of the innovative melatonin-loaded lipid-enriched hybrid system compared to conventional melatonin-loaded chitosan microspheres. The hybrid system contained nanostructured lipid carrier incorporated in the chitosan matrix, in order to modify melatonin release and alter physicochemical characteristics of the delivery system. Stability testing was performed during a six-month period under two conditions: refrigerated (5 ± 3 °C) and at room temperature (25 ± 2 °C/60 ± 5 % RH). Samples stored at both conditions were analyzed in terms of particle size, zeta potential, moisture content and thermal properties. At the end of testing, drug content was determined in all samples. Dressings wound healing potential was assessed by in vitro scratch test using human skin fibroblast cell line. Although both systems showed good stability characteristics, the addition of lipids in the system has improved its wound healing potential.

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Wound healing related agents: Ongoing research and perspectives

Cited by 73 publications

References 141 publications

Modulation of vascular endothelial growth factor and mitogen‐activated protein kinase‐related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing

Modulation of vascular endothelial growth factor and mitogen‐activated protein kinase‐related pathway involved in extracorporeal shockwave therapy accelerate diabetic wound healing

Caracterización Biomolecular Mediante Microespectroscopía FTIR en la Fase de Remodelación de la Cicatrización en un Modelo Murino de Lesión Excisional

Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres

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