Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers

Pengzong, Zhang; Li, Yuanmin; Xiong, Xiaoming; Deng, Shang; Xiong, Wei; Zhigang, Lang; Dongzhou, Du; Yu, Wenkui; Jianbiao, Yue; Xiang, Yu‐Tao; Li, Xia

doi:10.1055/a-0881-3000

“…The anti-inflammatory and antioxidative effects displayed by B. serrata extract suggest a new supportive treatment option in acute systemic inflammation and wound healing (Loeser et al 2018 ; Pengzong et al 2019 ). Also, B. serrata extract and boswellic acids both counteract free radicals (ROS) and significantly protect the intestinal epithelial barrier from inflammatory damage and inhibit NF-B phosphorylation induced by inflammatory stimuli (Catanzaro et al 2015 ).…”

Section: Potential Therapeutic Effects Of Boswellic Acids/ B Serrata Extract Against Sars-cov-2-induced Modification Omentioning

confidence: 99%

Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly

Gomaa

¹

,

Mohamed

²

,

Abd-ellatief

³

et al. 2021

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The most severe cases of COVID-19, and the highest rates of death, are among the elderly. There is an urgent need to search for an agent to treat the disease and control its progression. Boswellia serrata is traditionally used to treat chronic inflammatory diseases of the lung. This review aims to highlight currently published research that has shown evidence of potential therapeutic effects of boswellic acids (BA) and B. serrata extract against COVID-19 and associated conditions. We reviewed the published information up to March 2021. Studies were collected through a search of online electronic databases (academic libraries such as PubMed, Scopus, Web of Science, and Egyptian Knowledge Bank). Several recent studies reported that BAs and B. serrata extract are safe agents and have multiple beneficial activities in treating similar symptoms experienced by patients with COVID-19. Because of the low oral bioavailability and improvement of buccal/oral cavity hygiene, traditional use by chewing B. serrata gum may be more beneficial than oral use. It is the cheapest option for a lot of poorer people. The promising effect of B. serrata and BA can be attributed to its antioxidant, anti-inflammatory, immunomodulatory, cardioprotective, anti-platelet aggregation, antibacterial, antifungal, and broad antiviral activity. B. serrata and BA act by multiple mechanisms. The most common mechanism may be through direct interaction with IκB kinases and inhibiting nuclear factor-κB-regulated gene expression. However, the most recent mechanism proposed that BA not only inhibited the formation of classical 5-lipoxygenase products but also produced anti-inflammatory LOX-isoform-selective modulators. In conclusion a small to moderate dose B. serrata extract may be useful in the enhancing adaptive immune response in mild to moderate symptoms of COVID-19. However, large doses of BA may be beneficial in suppressing uncontrolled activation of the innate immune response. More clinical results are required to determine with certainty whether there is sufficient evidence of the benefits against COVID-19.

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“…The main components including Astragalus membranaceus [ 22 , 23 ], Salvia miltiorrhiza [ 24 ], and Safflower [ 25 ] and their extracts or monomers demonstrated the ability to upregulate the expression of VEGF/VEGFR2 in HUVECs and promote angiogenesis in vitro. The extracts or monomers of Angelica dahurica [ 26 ], Frankincense [ 27 ], Myrrh [ 28 ], and Bletilla striata [ 29 ] also showed antibacterial and anti-inflammatory effects in promoting wound healing. This is consistent with the theory of traditional Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect and Mechanism of Negative Pressure Wound Therapy with Huoxue Shengji Decoction Instillation for Chronic Skin Ulcers

Pan

¹

,

Xiong

²

,

Wang

³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Negative pressure wound therapy (NPWT) with instillation (NPWTi) is a new treatment for chronic skin ulcers (CSUs), but the choice of perfusate is still investigated. The clinical application of Huoxue Shengji (HXSJ) decoction has been proved to promote the formation of granulation. The formation of fresh granulation, angiogenesis, and proliferation of vascular endothelial cells are closely related. The purpose of this study was to observe the clinical efficacy of NWPT with HXSJ decoction instillation in the treatment of CSUs and to explore the potential mechanism by which HXSJ decoction promotes proliferation of vascular endothelial cells at the cellular level. Methods. In the clinical study, the random number table was used to divide the patients into three groups (patients were numbered by visit time and assigned a random number and grouped by the remainder after the random number was divided by 3, and when the number of patients in one group reached 20, the enrolment of this group is stopped), including NPWT combined with HXSJ decoction instillation (group A), NPWT combined with normal saline instillation (group B), and NPWT (group C). Related indexes were examined, including the wound cavity volume, bacterial culture, histopathology examination, time periods of debridement, repair methods, and the time of ulcer healing. In the basic research, the effect of HXSJ decoction on the proliferation of HUVECs was analysed by CCK-8 assay and RT-PCR and western blot were used to quantify the VEGF and VEGFR-2 expression in the relevant signalling pathway. Results. There was no significant difference in the improvement rate of invasive cavity volume ( P > 0.05 ) between groups A and B, but a significant difference was observed between groups A and C ( P < 0.05 ). There was no significant difference in microbial reduction among groups (all P > 0.05 ). Histopathological examination showed that the microvascular count in group A was significantly higher than that in groups B and C (both P < 0.01 ) and there was no statistical difference between groups B and C ( P > 0.05 ). There were no significant differences in the number of invasive lesions and repair methods among the groups (all P > 0.05 ). The healing time of group A was significantly faster than those of groups B and C (compared to group B, P < 0.05 ; compared to group C, P < 0.01 ), and there was no statistical difference between groups B and C ( P > 0.05 ). In the cellular experiments, concentration screening was performed and 125 μg/mL HXSJ decoction showed the most significant effect on the proliferation of HUVECs and also enhanced the expression of VEGF and VEGFR-2. Conclusion. HXSJ decoction can enhance the expression of VEGF and VEGFR-2 and promote the proliferation of HUVECs. Treatment with NWPT with HXSJ decoction instillation can further reduce the wound cavity volume; meanwhile, it can promote blood vessel formation in ulcer wounds, thus accelerating the healing of CSUs.

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“…Zhang P et al, evaluate the wound healing activity of standardized extract of Boswellia serrata against the experimental model of diabetic foot ulcer. Zhang et al, concluded that treatment with B. serrata (200 and 400 mg/kg) significantly increased the rate of wound contraction via modulation of oxido-nitrosative stress and elevated the hydroxyproline level at the wound area [33]. Surjeet Singh et al, evaluated the activity of boswellic acids derived from Boswellia serrata on animal models and study results discovered that boswellic acids possess a dose dependent antiulcer effect against different experimental models.…”

Section: Ulcer Healing Propertymentioning

confidence: 99%

Medicinal uses of Boswellia serrata Roxb (Kundur) with special reference to its ulcer healing property

Hafeel¹,

Rizwana²

2021

J Pharmacogn Phytochem

0

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Boswellia serrata is known as Kundur in Unani Medicine and the plant is found in Arabia, South Africa and west Asia. The white to yellow colored aromatic oleo resin gum is obtained from the stem bark of this pant and the main constituents of Boswellia serrata Roxb is Boswellic acid. This article was aimed to investigate and compile the pharmacological profile mentioned in Classical text of Unani medicine with special attention to its ulcer healing action and to scientifically recognize those pharmacological actions through the already published scientific studies. Pharmacological activities of kundur mentioned in Unani medicine are astringent, desiccative to the ulcer, antiseptic, haemostatic, cicatrizant, memory tonic, siccative to the secretion of phlegm, carminative, tissue formation and ulcer healing action. The active constituents of Boswellia serrata had proved effective in many experimental and clinical studies for various disease conditions.

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Wound Healing Potential of the Standardized Extract of Boswellia serrata on Experimental Diabetic Foot Ulcer via Inhibition of Inflammatory, Angiogenetic and Apoptotic Markers

Cited by 19 publications

References 34 publications

Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly

Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly

Therapeutic Effect and Mechanism of Negative Pressure Wound Therapy with Huoxue Shengji Decoction Instillation for Chronic Skin Ulcers

Medicinal uses of Boswellia serrata Roxb (Kundur) with special reference to its ulcer healing property

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