Wound healing potential of silver nanoparticles embedded in optimized bio-inspired hybridized chitosan soft and dry hydrogel

Abdel-Gawad, Roxane; Osman, Rihab; Awad, Gehanne A.S.; Mortada, Nahed

doi:10.1016/j.carbpol.2023.121526

Cited by 12 publications

(3 citation statements)

References 46 publications

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“…Collagen molecules can also establish hydrogen bonds, which can further strengthen the hydrogel. [34] Moreover, previous studies demonstrate that the mechanical properties of the collagen/HA hydrogel display variation, contingent upon the concentrations and fabrication methods employed. [35] Avendano et al [36] reported that the hydrogel composed of collagen and HA showed a stiffness range from 7 to 23 kPa, which was in line with our findings.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Preparation of Short Collagen Nanofibers for Injectable Hydrogels: Comparative Assessment of Fragmentation Methods, Physicomechanical Properties, and Biocompatibility

Karimizade,

Mellati

2024

Macro Materials & Eng

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Collagen nanofibers can be employed in hydrogels to create injectable nanocomposite hydrogels, mimicking the fibrous architecture of the natural extracellular matrix (ECM). As long continuous electrospun collagen nanofibers are not applicable, fragmentation is inevitable to obtain injectable hydrogels with a fine viscosity. Here, four methods: hand grinding (HG), homogenizer (HM), mixer milling (MM), and ultrasonication (UH) are used to disintegrate and shorten collagen nanofiber mats before incorporation into an injectable hyaluronic acid hydrogel as a matrix. The Length‐to‐diameter (L/d) ratio and morphology of fragmented collagen are compared by SEM. The injection force, mechanical properties, and cell viability of the selected collagen‐incorporated hydrogels are also evaluated. UH emerges as the most effective method, yielding the highest L/d ratio of 46 and a notable compressive modulus of 8.7 ± 0.92 kPa. Assessment of the in vitro cell viability of the encapsulated chondrocytes in the collagen‐incorporated hydrogels demonstrates good biocompatibility, and hydrogels containing UH short nanofiber, in particular, show an increase in cell proliferation. This work indicates how collagen mats can be effectively broken down and combined with injectable hydrogels to enhance both their mechanical behavior and biocompatibility.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Preparation of Short Collagen Nanofibers for Injectable Hydrogels: Comparative Assessment of Fragmentation Methods, Physicomechanical Properties, and Biocompatibility

Karimizade,

Mellati

2024

Macro Materials & Eng

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“…Hydrogels have garnered significant attention in wound healing due to their unique properties that make them well-suited for creating an optimal environment for tissue repair. , These three-dimensional networks of hydrophilic polymers can hold large amounts of water or biological fluids, providing a moist and supportive environment for wound healing. , …”

Section: Introductionmentioning

confidence: 99%

“…4,5 These three-dimensional networks of hydrophilic polymers can hold large amounts of water or biological fluids, providing a moist and supportive environment for wound healing. 6,7 Soy protein isolate (SPI) and collagen are known in the biomedical field for their biocompatibility and good biological properties. SPI, derived from soybeans, is rich in bioactive compounds, including peptides, which have demonstrated antiinflammatory and antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

Esmaeili,

Ghoraishizadeh,

Farzan

et al. 2024

ACS Appl. Bio Mater.

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Chronic wounds, such as diabetic ulcers and pressure sores, pose significant challenges in modern healthcare due to their prolonged healing times and susceptibility to infections. This study aims to engineer a bilayered wound dressing (BLWD) composed of soy protein isolate/collagen with the ability to release Cinnamaldehyde, Artemisia absinthium (AA), and oxygen. Cinnamaldehyde, magnesium peroxide (MgO 2 ), and AA extract were encapsulated. Nanoparticles were evaluated using scanning electron microscopy (SEM), dynamic light scattering, and ZETA potential tests. Swelling, degradation, water vapor penetration, tensile, MTT, SEM, oxygen release, AA extract release, and antibacterial properties were performed. An in vivo study was carried out to assess the final wound dressing under Hematoxiline&Eosin and Masson trichrome staining analysis and compared to a commercial product. According to the results, the synthesized nanoparticles had an average diameter of about 20 nm with a zeta potential in the range of −20 to −30 mV. The layers had uniform and dense surfaces. The maximum swelling and degradation of the dressing was about 130 and 13% respectively. Generally, better mechanical properties were observed in BLWD than in the single-layer case. More than 90% biocompatibility for the wound dressing was reported. The BLWD could inhibit the growth of Gram-positive and Gram-negative microorganisms. Histopathological analysis showed an acceptable wound-healing property. To sum up, the engineered wound dressing can be a good candidate for more clinical trials.

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A comprehensive review on genipin: an efficient natural cross-linker for biopolymers

Wahba

2024

Polym. Bull.

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Cross-linkers are pivotal to meliorate the attributes of the biopolymers, which are exploited in the biomedical industries, and also those intended as packaging supplies. Genipin (GN) is an efficacious cross-linker. Moreover, being naturally procured, biodegradable and biocompatible makes it an auspicious candidate for the biomedical and food industries. Accordingly, we attempted to provide a comprehensive review on GN as an efficient cross-linker for biopolymers. Initially, we presented the chief botanical sources of GN. The GN extraction strategies, which adopted safe solvents, were then discussed while highlighting their realized yields. The proposed GN structures, its possible modes of action, and the factors affecting its interactions, such as pH, temperature, and GN concentration were also reviewed. Afterward, the GN applications that mainly involved cross-linking biopolymers and biopolymers containing materials were discussed. These included tissue engineering, wound dressings, drug delivery, and packaging applications. GN capability to activate biopolymers, such as chitosan and gelatin, into covalently reactive enzyme immobilizers was also discussed. Moreover, other important GN applications, such as exploiting it as a colorant for foods and textiles and incorporating it in altered biosensors, were discussed.

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Wound healing potential of silver nanoparticles embedded in optimized bio-inspired hybridized chitosan soft and dry hydrogel

Cited by 12 publications

References 46 publications

Preparation of Short Collagen Nanofibers for Injectable Hydrogels: Comparative Assessment of Fragmentation Methods, Physicomechanical Properties, and Biocompatibility

Preparation of Short Collagen Nanofibers for Injectable Hydrogels: Comparative Assessment of Fragmentation Methods, Physicomechanical Properties, and Biocompatibility

Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

A comprehensive review on genipin: an efficient natural cross-linker for biopolymers

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