Wound healing potential of selected Southern African medicinal plants: A review

Chingwaru, Constance; Bagar, Tanja; Maroyi, Alfred; Kapewangolo, Petrina T.; Chingwaru, Walter

doi:10.1016/j.hermed.2019.100263

Cited by 22 publications

(19 citation statements)

References 54 publications

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“…Phenolic acids derived from hydroxybenzoic acid (gallic acid, 4-OH benzoic acid, 4-OH benzaldehyde), hydroxycinnamic acid (chlorogenic acid, caffeic acid) and a flavan-3-ol (catechin), have been identified in the methanol leaf extract of S. columbaria (Akar, 2021). Although one needs to be cautious to extrapolate from these studies, it remains interesting to note that wound healing properties have been ascribed to these phenolics (Chingwaru et al, 2019). Gallic acid induced wound healing potential through anti-oxidant capacity, acceleration of cell migration of human keratinocytes and fibroblasts in both normal and hyperglucidic conditions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays

Mhlongo

Cordero-Maldonado

Crawford

et al. 2022

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Evaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays

Mhlongo

Cordero-Maldonado

Crawford

et al. 2022

Journal of Ethnopharmacology

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“…It was argued that any medicinal plant species or natural pharmaceutical product to be classified as a good wound healing agent, it should possess antibacterial and antiinflammatory properties among other pharmacological properties (112,113). The wound healing process begins with the polarisation of cells towards the wound, initiation of protrusion and cell migration, which culminate in closure of the wound area (114,115). Most of these plant species used to treat and manage circumcision appear to accelerate the wound healing process.…”

Section: Antibacterial and Anti-inflammatory Activitiesmentioning

confidence: 99%

Use of herbal formulations for the treatment of circumcision wounds in Eastern and Southern Africa

Maroyi¹

2021

Plant Sci. Today

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Medicinal plants used to treat and manage circumcision wounds have remained an integral part of traditional practice in Eastern and Southern Africa. This study reviews the traditional usage of medicinal plants to treat and manage circumcision wounds in Eastern and Southern Africa. Drawing on data from Kenya, Namibia, South Africa and Tanzania, information was collected from different sources including books, theses and electronic scientific search engines such as Scopus, Science Direct, PubMed, SciFinder and Google Scholar. A literature search was also undertaken focusing on medicinal plants used against circumcision wounds that demonstrated antibacterial and anti-inflammatory activities in in vitro studies. Twenty-eight medicinal plants from 15 families are recorded as traditional therapies for circumcision wounds following an extensive literature search. These species used to treat and manage circumcision wounds, and as dressing after circumcision to prevent serious inflammation are mainly (64.3%) members of Amaryllidaceae, Asparagaceae, Asteraceae, Euphorbiaceae and Fabaceae families. Three quarters (75.0%) of these species including Acalypha ornata, Achyranthes aspera, Asparagus africanus, Boophone disticha, Brunsvigia grandiflora, Burkea africana, Colophospermum mopane, Datura stramonium, Dichrostachys cinerea, Helichrysum appendiculatum, H. foetidum, H. longifolium, H. nudifolium, H. pedunculatum, Lippia javanica, Maesa lanceolata, Ptaeroxylon obliquum, Ricinus communis, Searsia natalensis, Triumfetta rhomboidea and Vachellia nilotica have shown antibacterial and anti-inflammatory effects in a set of in vitro models. Further studies are needed such as isolation of phytochemical compounds, in vivo activities, clinical and toxicological studies.

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“…For example, tannins are bacterial growth inhibitors, and terpenoids have astringent and antimicrobial properties. In addition, flavonoids and anthocyanins are powerful antioxidants, anti-inflammatory, and antimicrobial phytoconstituents [1,6,20]. These phytocompounds can contribute to healing independently or synergistically [11,21].…”

Section: Introductionmentioning

confidence: 99%

Wound healing activity of Tropaeolum tuberosum-based topical formulations in mice

et al. 2022

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Background and Aim: Tropaeolum tuberosum Ruiz and Pavón, a tuber native to South America, is characterized by its antioxidant, antimicrobial, and anti-inflammatory properties that contribute to wound healing. This study aimed to evaluate the healing effect of the topical T. tuberosum formulations (gel and cream) on induced wounds in mice. Materials and Methods: Here, an acidic ethanolic extract (1.5 N hydrochloric acid and 96% ethanol at the ratio of 15:85, v/v) was prepared with the tubers of T. tuberosum ecotype black and incorporated into topical cream and gel formulations at 1%. Thirty-twoBalb/c mice were divided into four experimental groups receiving daily topical treatments for 14 days: Group I (control; no treatment), Group II (a commercial ointment of neomycin, polymyxin B, and bacitracin), Group III (1% T. tuberosum gel), and Group IV (1% T. tuberosum cream). The wound closure in the mice was determined during the treatment; then, they were euthanized to obtain skin samples for histopathological analysis. Results: Groups III and IV showed a higher percentage of wound closure from the 6th day of the treatment. From the 8th day, the effect was greater in Group III. The healing effect was confirmed by the histopathological changes. Conclusion: This study concludes that the topical formulations of T. tuberosum demonstrate wound-healing activity in mice, and the most effective treatment is the 1% gel formulation.

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Wound healing potential of selected Southern African medicinal plants: A review

Cited by 22 publications

References 54 publications

Evaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays

Evaluation of the wound healing properties of South African medicinal plants using zebrafish and in vitro bioassays

Use of herbal formulations for the treatment of circumcision wounds in Eastern and Southern Africa

Wound healing activity of Tropaeolum tuberosum-based topical formulations in mice

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