Wound Healing Potential of Ethanolic Extract of Tecoma stans Flowers in Rats

Kameshwara, S.; Senthilkum, R.; Thenmozhi, S.; Dhanalaksh, M.

doi:10.5567/pharmacologia.2014.215.221

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…Research on wound healing agents is one of the emerging areas in modern biomedical sciences (33)(34)(35)(36)(37). For medicinal plants to properly contribute to affordable healthcare, they must be scientifically assessed; phytochemical screenings are often considered as the first step towards the discovery of useful drugs (38,39). Successive solvent extraction techniques, as well as chromatographic separations and spectroscopic methods, have been used to determine the chemical constituents of plants and study their bioactivity as it applies to traditional medicine (32,37).…”

Section: Plant-derived Wound Healing Agentsmentioning

confidence: 99%

Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities

Vijayaraghavan

Rajkumar²,

Bukhari

et al. 2017

Molecular Medicine Reports

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The study of wound‑healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are available for wound care and management, it remains necessary to search for efficacious treatments, as certain current formulations cause adverse effects or lack efficacy. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via various mechanisms. Several herbal medicines have displayed marked activity in the management of wounds and various natural compounds have verified in vivo wound healing potential, and can, therefore, be considered as potential drugs of natural origin. Chromolaena odorata (L.) R.M. King and H. Robinson is considered a tropical weed. However, it exhibits anti‑inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable healthcare, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future drug design, development and application for the treatment of wounds.

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Section: Plant-derived Wound Healing Agentsmentioning

confidence: 99%

Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities

Vijayaraghavan

Rajkumar²,

Bukhari

et al. 2017

Molecular Medicine Reports

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“…The chloroform fractions showed prevention as compared to fractions from other solvents. S. Kameshwaran et al, 2014(a) through in-vitro experiments found that 10% ethanolic extracts of Tecoma stans flowers ointment have significant wound healing properties. It efficiently stimulated wound contractions, increased tensile strength of incision and burnt wounds.…”

Section: Plant Descriptionmentioning

confidence: 99%

An Appraise on Tecoma Stans (L.) Ex. Juss, Kunth. - Phytochemical Potentials

Fernandes¹,

Mankad²

2022

IABCD

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Tecoma is naturally distributed in the tropical and sub-tropical parts of Central Mexico and South Florida, Central America, Carribean and South America and Northern Argentina. Tecoma is a perennial flowering shrub, 5-8 m in height.Tecoma stans is drought resistant fast growing ornamental plant which grows throughout India. It is commonly called as yellow trumpet bush, yellow bells, yellow elder, ginger Thomas. In Hindi it is known as Piliya/ Pila kaner. Flowers occur in clusters and are trumpet-shaped with 5 round lobes, pale to bright yellow, with faint orange stripes at the throat of the corolla tube. The flowers of Tecoma are the official flowers of the United States Virgin Island and also the floral emblem of the Bahamas. This review intends to infer an insight to the in vitro phyto-constituents composition and their respective characteristic pharmacological properties of leaves and flowers of Tecoma stans.

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“…Many biological activities were confirmed, especially those based on folk use as a hypoglycemic and hypolipidemic agent for diabetes mellitus [32]. In addition, Tecoma stans has wound-healing [33], antioxidant, antimicrobial [34], analgesic, anti-inflammatory [35], nephroprotective [36], and cardioprotective activities [29].…”

Section: Introductionmentioning

confidence: 99%

Anti-Oral Pathogens of Tecoma stans (L.) and Cassia javanica (L.) Flower Volatile Oils in Comparison with Chlorhexidine in Accordance with Their Folk Medicinal Uses

2019

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Background and Objectives: Teeth decay and plaque are complicated problems created by oral pathogens. Tecoma stans (L.) and Cassia javanica (L.) are two ornamental evergreen plants widely distributed in Egypt. These plants are traditionally used for oral hygienic purposes. This study aims to elucidate the volatile oil constituents obtained from the flowers of these plants and evaluate the antimicrobial activity of these volatile oils against specific oral pathogens in comparison to chlorhexidine. Materials and Methods: The flowers obtained from both plants were extracted by n-hexane. GC-MS spectrometry was used to identify the constituents. Minimum inhibitory concentrations (MICs) were measured using tetrazolium salt (2,3-bis[2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide) (XTT). Results: GC-MS analysis revealed the presence of 32 and 29 compounds, representing 100% of the volatile constituents of Tecoma stans and Cassia javanica, respectively. The GC-MS analysis showed more than 60% of the volatile oil constituents are represented in both plants with different proportions. Chlorhexidine exerted stronger activity than tested plants against all microorganisms. Cassia javanica flower extract was more active against all tested microorganisms than Tecoma stans. Of note was the effect on Streptococcus mutans, which was inhibited by 100% at 12.5 and 25 µg/mL of Cassia javanica and Tecoma stans, respectively. The growth of Lactobacillus acidophilus was also completely inhibited by 25 µg/mL of the Cassia javanica extract. MIC90 and MIC were also calculated, which revealed the superiority of Cassia javanica over Tecoma stans against all tested oral pathogens. Conclusion: Cassia javanica flower volatile oils showed a potential anti-oral pathogen activity at relatively low concentrations. Also, Cassia javanica and Tecoma stans demonstrated a strong activity against tooth decay’s notorious bacteria Streptococcus mutans. Both plants can be potential substituents to chlorhexidine. Formulating the constituents of these plants in toothpastes and mouthwashes as anti-oral pathogen preparations can be an interesting future plan.

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Wound Healing Potential of Ethanolic Extract of Tecoma stans Flowers in Rats

Cited by 10 publications

References 18 publications

Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities

Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities

An Appraise on Tecoma Stans (L.) Ex. Juss, Kunth. - Phytochemical Potentials

Anti-Oral Pathogens of Tecoma stans (L.) and Cassia javanica (L.) Flower Volatile Oils in Comparison with Chlorhexidine in Accordance with Their Folk Medicinal Uses

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