Wound healing potential of antibacterial microneedles loaded with green tea extracts

Park, So Young; Lee, Hyun Uk; Lee, Young-Chul; Kim, Gun-Hwa; Park, Edmond Changkyun; Han, Seung Hyun; Lee, Jeong Gyu; Choi, Seo Young; Heo, Nam Su; Kim, Dong Lak; Huh, Yun Suk; Lee, Jun Young

doi:10.1016/j.msec.2014.06.021

Cited by 71 publications

(44 citation statements)

References 33 publications

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“…MNA devices have recently been used in wound healing models to deliver antioxidants, antibacterial, and angiogenic drugs. Park et al designed a HA dissolving MNA containing a green tea extract [158]. The main components present in this extract are polyphenols and catechins, which have previously shown inhibitory effects against Gram-positive and Gram-negative bacteria.…”

Section: Cosmeceuticalsmentioning

confidence: 99%

Microneedle-Based Delivery: An Overview of Current Applications and Trends

et al. 2020

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Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.

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Section: Cosmeceuticalsmentioning

confidence: 99%

Microneedle-Based Delivery: An Overview of Current Applications and Trends

et al. 2020

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“…Antimicrobial microneedle patches on gingiva could be used to augment periodontal wound healing. Microneedles loaded with antibacterial agents such as green tea and self-sterilizing dissolving nanosilver-loaded patches are being experimented to suppress microbial load at the wound site 9,10 .Also, platelet concentrates such as platelet-rich plasma, platelet-rich fibrin, and growth factors could be administered with the help of microneedles to accelerate healing.…”

Section: Current and Prospective Applications In Dentistrymentioning

confidence: 99%

Microneedles and Nanopatches-Based Delivery Devices in Dentistry

Batra

Dawar

Miglani

2020

Discoveries (Craiova)

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Needle-based devices are evolving as a promising diagnostic and therapeutic tool in the field of medicine. They can be used for drug delivery, as well as extraction of fluids, for systemic and local effects. The conventional methods of drug delivery require repeated dosing in the oral cavity due to the presence of saliva. Hence delivery systems, such as needle-based devices that could provide sustained release of the drug in the oral cavity, are required. These devices could also be a useful adjunct in diagnosis and therapy of oral cancers, delivering anti-cariogenic and antiplaque agents, for remote monitoring of oral health, and for administering painless and fearless local anesthesia. Since they offer many advantages, such as increased compliance, absence of needle phobia, they are painless, safe, self-applicable and are minimally invasive, they will have a major impact in the field of dentistry. This paper summarizes the various types of needle-based devices and their manufacturing technologies. The manuscript aims to serve as a foundational review that highlights and proposes several current and prospective impactful applications of these devices in various fields of dentistry.

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“…Across multiple physiological time scales associated with wound type and wound healing [ 17 ] the use of MNs has been investigated in the following areas: (a) antimicrobial wound treatment [ 18 , 19 , 20 ]; (b) proliferation of endothelial cells [ 21 , 22 ]; (c) scar repair [ 22 , 23 ]; and, (d) treatment of chronic wounds and burns [ 24 , 25 ]. Related cutting edge applications of MNs include biointerfacing [ 26 ], wound detection [ 27 ], and smart bandages under development combining detection and delivery [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

et al. 2018

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Cell-hydrogel based therapies offer great promise for wound healing. The specific aim of this study was to assess the viability of human hepatocellular carcinoma (HepG2) cells immobilized in atomized alginate capsules (3.5% (w/v) alginate, d = 225 µm ± 24.5 µm) post-extrusion through a three-dimensional (3D) printed methacrylate-based custom hollow microneedle assembly (circular array of 13 conical frusta) fabricated using stereolithography. With a jetting reliability of 80%, the solvent-sterilized device with a root mean square roughness of 158 nm at the extrusion nozzle tip (d = 325 μm) was operated at a flowrate of 12 mL/min. There was no significant difference between the viability of the sheared and control samples for extrusion times of 2 h (p = 0.14, α = 0.05) and 24 h (p = 0.5, α = 0.05) post-atomization. Factoring the increase in extrusion yield from 21.2% to 56.4% attributed to hydrogel bioerosion quantifiable by a loss in resilience from 5470 (J/m3) to 3250 (J/m3), there was no significant difference in percentage relative payload (p = 0.2628, α = 0.05) when extrusion occurred 24 h (12.2 ± 4.9%) when compared to 2 h (9.9 ± 2.8%) post-atomization. Results from this paper highlight the feasibility of encapsulated cell extrusion, specifically protection from shear, through a hollow microneedle assembly reported for the first time in literature.

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Wound healing potential of antibacterial microneedles loaded with green tea extracts

Cited by 71 publications

References 33 publications

Microneedle-Based Delivery: An Overview of Current Applications and Trends

Microneedle-Based Delivery: An Overview of Current Applications and Trends

Microneedles and Nanopatches-Based Delivery Devices in Dentistry

Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion

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