“…Based on mathematical models and clinical data on conventional care, researchers proposed that wound size, age, elapsed time from wound appearance to the beginning of the treatment, initial healing rate during the first 2-4 weeks of treatment, skin perfusion pressure, body mass index (BMI), type of treatments and others may be related to and are important prognostic factors in wound healing [13][14][15][16][17][18][19][20][21][22]. Nonetheless, specific predictors differ in the literature [13][14][15][16][17][18][19][20][21][22], and understandings of factors affecting wound healing using E-stim are limited. To our best knowledge, only one study reported prognostic factors in wound healing with E-stim, which included wound size, patient's age, elapsed time from wound appearance to the beginning of the treatment, width-to-length ratio, location and type of treatment [23].…”