Wound healing in children as assessed by the CELLSTIC method

Viljanto, J; Raekallio, J

doi:10.1016/0022-3468(76)90168-8

Cited by 37 publications

(21 citation statements)

References 7 publications

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“…Heikkinen et al (1971) of an increased activity of some enzymes necessary for energy metabolism in the wounds of young individuals indicates their greater metabolic capacity. The more pronounced infiltration of inflammatory cells and fibroblasts observed in skin wounds of younger individuals (Viljanto & Raekallio 1976) was also clearly demonstrated in this study. The connective scar tissue formation was less intense in the injuries of old rats, a phenomenon which parallels our earlier observations in immobilized muscle (Jarvinen 1975) with a marked decrease in the tensile properties ).…”

Section: Discussionsupporting

confidence: 61%

“…This study demonstrated a decreased repair capacity in striated muscle with advanced age, a phenomenon which has been described in the context of healing in other tissues, e.g. fractures of bones (Ah0 1966) and skin wounds (Learning 1963, Viljanto & Raekallio 1976, Goodson & Hunt 1979. A decrease in repair similar to that seen in the old rats was demonstrated in our earlier studies by immobilizing the injured muscle.…”

Section: Discussionmentioning

confidence: 59%

“…In skin wounds, the PO, tension in the dead space of a wound was lower in young animals (Holm-Pedersen & Zederfeld 1972), which may be caused by the higher oxygen consumption of the wound tissue of younger rats. The observation of Viljanto & Raekallio (1976) and . Heikkinen et al (1971) of an increased activity of some enzymes necessary for energy metabolism in the wounds of young individuals indicates their greater metabolic capacity.…”

Section: Discussionmentioning

confidence: 99%

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Age Dependent Repair of Muscle Rupture: A Histological and Microangiographical Study in Rats

Järvinen

Aho

Lehto³

et al. 1983

Acta Orthopaedica Scandinavica

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Age Dependent Repair of Muscle Rupture: A Histological and Microangiographical Study in Rats

Järvinen

Aho

Lehto³

et al. 1983

Acta Orthopaedica Scandinavica

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“…The mean time to heal in children was 24.06 days, while in adults it was 32.34 days, with the overall mean being 28.19 days. It has been shown that wounds in children heal quicker and this is further attested to by our study [23]. In addition, it also enables us to appreciate the significant time span necessary for such an injury to heal.…”

Section: Discussionsupporting

confidence: 75%

Burn Injuries Resulting from Hot Water Bottle Use: A Retrospective Review of Cases Presenting to a Regional Burns Unit in the United Kingdom

Jabir

Frew

El-Muttardi

et al. 2013

Plastic Surgery International

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Introduction. Hot water bottles are commonly used to relieve pain and for warmth during the colder months of the year. However, they pose a risk of serious burn injuries. The aim of this study is to retrospectively review all burn injuries caused by hot water bottles presenting to our regional burns unit. Methods. Patients with burns injuries resulting from hot water bottle use were identified from our burns database between the periods of January 2004 and March 2013 and their cases notes reviewed retrospectively. Results. Identified cases involved 39 children (aged 17 years or younger) and 46 adults (aged 18 years or older). The majority of burns were scald injuries. The mean %TBSA was 3.07% (SD ± 3.40). Seven patients (8.24%) required debridement and skin grafting while 3 (3.60%) required debridement and application of Biobrane. One patient (1.18%) required local flap reconstruction. Spontaneous rupture accounted for 48.20% of injuries while accidental spilling and contact accounted for 33% and 18.80% of injuries, respectively. The mean time to heal was 28.87 days (SD ± 21.60). Conclusions. This study highlights the typical distribution of hot water bottle burns and the high rate of spontaneous rupture of hot water bottles, which have the potential for significant burn injuries.

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“…These effects produced by mannose-6-phosphate resemble greatly the effects of mannose in our experiment. The reason for this similarity may be mannose being metabolized to mannose-6-phosphate in a healing wound while elevated levels of hexokinase are observed in healing wounds [26,27].…”

Section: Discussionmentioning

confidence: 99%

Effects of Hexose Sugars: Glucose, Fructose, Galactose and Mannose on Wound Healing in the Rat

Kössi¹,

Ekfors

Niinikoski³

et al. 1999

Eur Surg Res

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The effects of four hexose sugars (D-glucose, D-fructose, D-galactose, D-mannose) on the developing granulation tissue in rats were examined. Cylindrical hollow sponge implants were used as an inductive matrix for the growth of granulation tissue. In the test group, the implants were injected with 0.1 ml of solution containing the different hexoses in 0.01, 0.1 and 1 M concentrations daily for 7 days while the implants of the control groups were injected with 0.1 ml of phosphate-buffered saline solution only. Analyses of granulation tissue and wound fluid in the sponge implants were carried out 7 days after implantation. The results demonstrated that galactose caused a significant increase in the accumulation of granulation tissue as estimated by histological analyses, but no significant differences were observed in various chemical analyses. In striking contrast, statistically significant decreases were observed in the number of leukocytes in wound fluid, in the amount of DNA, RNA, collagen hydroxyproline, nitrogen, hexosamines and uronic acids in sponges treated with 0.1 or 1 M mannose, reflecting decreased granulation tissue formation. This effect was also observed in histological analyses of the specimens. There were no major changes in sponges treated with glucose or fructose. In summary, the findings of the present study demonstrate that galactose may enhance wound healing and mannose treatment inhibits the inflammatory reaction in wound healing and decreases granulation tissue formation in an experimental wound model.

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Wound healing in children as assessed by the CELLSTIC method

Cited by 37 publications

References 7 publications

Age Dependent Repair of Muscle Rupture: A Histological and Microangiographical Study in Rats

Age Dependent Repair of Muscle Rupture: A Histological and Microangiographical Study in Rats

Burn Injuries Resulting from Hot Water Bottle Use: A Retrospective Review of Cases Presenting to a Regional Burns Unit in the United Kingdom

Effects of Hexose Sugars: Glucose, Fructose, Galactose and Mannose on Wound Healing in the Rat

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