Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats

Reddy, J.Suresh; Rao, Pragada Rajeswara; Reddy, Mada S.

doi:10.1016/s0378-8741(01)00388-9

Cited by 110 publications

(66 citation statements)

References 10 publications

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“…Such a radical scavenging action contributes to prevent deleterious effects from reactive oxygen species generated by the inflammatory conditions (Halliwell and Gutteridge, 1999;Singh et al, 2006), and most probably plays a part in the wound healing properties of A. monostachya. However, the antioxidant capacity and wound healing activity had been studied in other species of genus Acalypha [A. indica (SC 50 = 37.9 µg/mL and 28% as gallic acid equivalents and the ethanolic extract showed wound healing activity) and A. langiana (topical application of aqueous extract from leaves decreased the wounds area by 9 to 88% and 8 to 82% in excision and incision wound, respectively)] (Reddy et al, 2002;Perez Gutierrez and Vargas, 2006;Marwah et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Canales¹

2011

Afr. J. Pharm. Pharmacol.

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Acalypha monostachya (Euphorbiaceae) is used by the inhabitants of San Rafael and ZapotitlanSalinas, Puebla, Mexico, to alleviate illnesses of bacterial and fungal origin. We analyzed the antimicrobial activity of A. monostachya and some of its chemical features. The extracts were obtained by percolation. The antibacterial and antifungal activities were examined through the disc-diffusion method. The general toxicity was carried out by using Artemia salina. The quenching of free radicals by extracts was evaluated by the decolouration of a methanol solution of DPPH·. Total phenols were determined by Folin Ciocalteu reagent. Gram-positive and negative bacteria were sensitive to methanol and hexane extracts. The methanol extract had a bactericidal effect on Vibrio cholera Tor (MIC = 1000 µg/mL). The fungi strain most sensitive to this extract was T. mentagrophytes (LC 50 = 430 µg/mL). The methanol extract showed inhibition of DPPH· radical (SC 50 = 3.45 µg/ml), 43.4% of total phenolics and was toxic against A. salina (LC 50 = 4.5 µg/mL). The methanol extract showed a variety of phenolic compounds, while hexane extract showed different fatty acids methyl ester. The bacterial, antifungal, antioxidant activities and a qualitative chemical characterization of A. monostachya's extracts are reported here for the first time.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Canales¹

2011

Afr. J. Pharm. Pharmacol.

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“…The sutures were removed on 8 th post wound day and continued the application of the extract. The wound breaking strength was measured on the 10 th day evening after the last application (Reddy et al, 2002). The results are tabulated in Table 2.…”

Section: Incision Wound Modelmentioning

confidence: 99%

Wound healing activity of Cleome rutidosperma DC. roots

Mondal

Suresh

2012

Int Curr Pharm J

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The petroleum ether, chloroform, methanol and aqueous extracts of Cleome rutidosperma DC (Family: Capparidaceae) roots were evaluated for their wound healing activities in rats using excision and incision wound models respective-ly. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation and wound breaking strength. Nitrofurazone (0.2% w/w) in simple ointment I.P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of C. rutidosperma showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plant also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of C. rutidosperma roots for wound healing activity as claimed in the folklore literature. DOI: http://dx.doi.org/10.3329/icpj.v1i6.10536 International Current Pharmaceutical Journal 2012, 1(6): 151-154

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“…The wound healing potential of Tridax procumbens (Udupa et al, 1995), Trigonella foenumgraecum (Taranalli, Kuppast, 1996), Leucas lavandulaefolia (Saha et al, 1997), Aloe vera (Chitra et al, 1998), Ageratum conyzoides (Chah et al, 2006), Dendrophthoe falcate (Pattanayak et al, 2008) and Heliotropium indicum, Plumbago zeylanicum, Aca-lypha indica (Reddy et al, 2002) have shown promising healing activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

Murti

Lambole²,

Panchal³

2011

Braz. J. Pharm. Sci.

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Ethanolic extract of roots of Ficus hispida was investigated in normal and dexamethasone depressed healing conditions, using incision, excision and dead space wound models in albino rats. The root extract of Ficus hispida has shown the maximum breaking strength compared to control group. The rate of epithelialization and wound contraction in excision model was better as compared to control groups. There was significant increase in granulation tissue weight and hydroxyproline content in dead space model compared to control group. The antihealing effect of dexamethasone was also reverted by the administration of ethanolic extract of Ficus hispida in all the wound models .The results indicated that the root extract of Ficus hispida has a significant wound healing activity and also promotes healing in dexamethasone depressed healing conditions. Uniterms: Ficus hispida/pharmacognosy. Ficus hispida/ethanolic extract/wound healing activity. Wound healing/experimental study. O extrato etanólico de raízes de Ficus hispida foi ensaiado em ratos albinos normais e em condições de cicatrização deprimida por dexametasona, utilizando modelos de ferida por incisão, excisão e de espaço morto. O extrato da raiz de Ficus hispida mostrou a força máxima de tensão comparativamente ao grupo controle. A velocidade de epitelização e de contração da ferida no modelo de excisão foi melhor do que a dos grupos controles. Houve aumento significativo no peso do tecido de granulação e no conteúdo de hidroxiprolina no modelo de espaço morto comparativamente ao grupo controle. O efeito anticicatrizante da dexametasona foi, também, revertido pela administração do extrato etanólico de Ficus hispida em todos os modelos de feridas. Os resultados indicaram que o extrato de Ficus hispida tem atividade cicatrizante em feridas e, também, promove a cicatrização em condições de depressão de cicatrização pela dexametasona. Unitermos:Ficus hispida/Farmacognosia. Ficus hispida/extrato etanólico/atividade cicatrizante. Cicatrização/estudo experimental.

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Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats

Cited by 110 publications

References 10 publications

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Wound healing activity of Cleome rutidosperma DC. roots

Effect of Ficus hispida L. on normal and dexamethasone suppressed wound healing

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