Wound-healing effects of 635-nm low-level laser therapy on primary human vocal fold epithelial cells: an in vitro study

Lou, Zhewei; Zhang, Chi; Gong, Ting; Xue, Chao; Scholp, Austin; Jiang, Jack J.

doi:10.1007/s10103-018-2628-0

Cited by 24 publications

(11 citation statements)

References 38 publications

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“…One way to suppress the severe inflammatory reaction in the lung (the fourth treatment protocol) is PBM. Antiinflammatory and regenerative effects of PBM have been observed in the treatment of allergic lung inflammation, vocal fold injuries, periodontitis, and oral lesions [16][17][18][19]. In comparison with medications, such as immunosuppressive drugs including corticosteroids PBM has mostly local effects, and its systemic effects are limited.…”

Section: Anti-inflammatory Effects Of Pbmmentioning

confidence: 99%

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Photobiomodulation therapy as a high potential treatment modality for COVID-19

2020

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COVID-19 is now a worldwide concern, causing an unprecedented pandemic. The infected cases show different symptoms based on the severity of the disease. In asymptomatic and non-severe symptomatic cases, the host immune system can successfully eliminate the virus and its effects. In severe cases, however, immune system impairment causes cytokine release syndrome which eventually leads to acute respiratory distress syndrome (ARDS). In recent years, photobiomodulation (PBM) has shown promising results in reducing acute pulmonary inflammation. Considering the high potential impact of PBM on immune responses, we hypothesized that using PBM could be an effective treatment modality for ARDS management in COVID-19 patients.

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Section: Anti-inflammatory Effects Of Pbmmentioning

confidence: 99%

“…World Health Organization (WHO) soon confirmed that human to human transmission of the virus has led to a worldwide "pandemic" [1]. The virus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing Coronavirus disease 2019 (COVID- 19).…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation therapy as a high potential treatment modality for COVID-19

2020

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“…These positive effects may be through the down-regulation of the TGF-β pathway and the reduced production of inflammatory mediators, and further reducing collagen secretion and deposition [132]. Luo et al also recently presented that low-level laser therapy can stimulate the proliferation and migration of human VF epithelial cells in culture as well as increase the expression of some genes involved in the tissue healing process [133]. From the same group, Gong et al recently demonstrated that cryotherapy which is the localized application of extremely cold temperatures for eliminating lesions or relieving physical suffering was effective to minimize VF scarring especially administered at the time of injury [134].…”

Section: New Strategies For Vf Scar Including Regenerative Medicinmentioning

confidence: 99%

Pathophysiology of Fibrosis in the Vocal Fold: Current Research, Future Treatment Strategies, and Obstacles to Restoring Vocal Fold Pliability

Kumai

2019

IJMS

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Communication by voice depends on symmetrical vibrations within the vocal folds (VFs) and is indispensable for various occupations. VF scarring is one of the main reasons for permanent dysphonia and results from injury to the unique layered structure of the VFs. The increased collagen and decreased hyaluronic acid within VF scars lead to a loss of pliability of the VFs and significantly decreases their capacity to vibrate. As there is currently no definitive treatment for VF scarring, regenerative medicine and tissue engineering have become increasingly important research areas within otolaryngology. Several recent reviews have described the problem of VF scarring and various possible solutions, including tissue engineered cells and tissues, biomaterial implants, stem cells, growth factors, anti-inflammatory cytokines antifibrotic agents. Despite considerable research progress, these technical advances have not been established as routine clinical procedures. This review focuses on emerging techniques for restoring VF pliability using various approaches. We discuss our studies on interactions among adipose-derived stem/stromal cells, antifibrotic agents, and VF fibroblasts using an in vitro model. We also identify some obstacles to advances in research.

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“…Maldaner et al 20 avaliaram o uso do laser de 660 nm, em cultura de fibroblastos, e observaram que a fluência de 4 J/cm 2 produziu importantes efeitos, como aumento na proliferação, aumento de IL-10, FGF-1 e KGF, além de reversão no estado de oxidação do DNA e redução de interleucinas inflamatórias (IL-1B, IL-6 e INFy). Além destes efeitos, o laser de baixa potência tem apresentado efeitos angiogênicos e aumento em diversos fatores de crescimento importantes no reparo tecidual 21,22 , por tais efeitos vislumbram-se possibilidades de alterações em estrias atróficas por parte destes equipamentos.…”

Section: Tabelaunclassified

Comparação Do Uso Do Laser De Baixa Potência (660 Nm E 830 Nm) Em Estrias Atróficas De Mulheres Jovens

Krüger¹,

Amadori²,

Vergutz³

et al. 2019

SaudPesq

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O laser de baixa potência é um recurso utilizado em lesões de pele, contudo ainda pouco explorado no tratamento de estrias alba. Objetivo: comparar dois comprimentos de laser de baixa potência (660 nm e 830 nm) sobre estrias albas. Um grupo de 24 mulheres foi dividido em três: G1 – 660 nm; G2 – 830 nm; G3 – placebo. Realizaram-se 12 aplicações de laser, durante quatro semanas. Foram avaliadas fotos das estrias no antes, depois e após duas semanas das aplicações do laser para mensurar a área ocupada pelas estrias por meio de planimetria digitalizada, bem como seus aspectos. Pela planimetria observou-se redução estatisticamente significativa na área ocupada em G1. Na análise qualitativa, o grupo tratado com laser de 660 nm apresentou melhora no aspecto das estrias. A aplicação utilizando o laser de baixa potência com comprimento de onda de 660 nm demonstrou efeitos positivos na área analisada, bem como no aspecto das estrias.

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Wound-healing effects of 635-nm low-level laser therapy on primary human vocal fold epithelial cells: an in vitro study

Cited by 24 publications

References 38 publications

Photobiomodulation therapy as a high potential treatment modality for COVID-19

Photobiomodulation therapy as a high potential treatment modality for COVID-19

Pathophysiology of Fibrosis in the Vocal Fold: Current Research, Future Treatment Strategies, and Obstacles to Restoring Vocal Fold Pliability

Comparação Do Uso Do Laser De Baixa Potência (660 Nm E 830 Nm) Em Estrias Atróficas De Mulheres Jovens

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