Wound healing center establishment and new technology application in improving the wound healing quality in China

Fu, Xiaobing

doi:10.1093/burnst/tkaa038

Cited by 12 publications

(8 citation statements)

References 15 publications

(16 reference statements)

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“…Wound healing not only influences the appearance of the patients, but also has a great impact of the function. Although there are some targeted methods for wound healing, it does not fundamentally solve the problem 1,2 . Wound healing consists of several distinct but overlapping stages, including haemostasis, inflammation, tissue remodelling and maturation 3‐5 .…”

Section: Introductionmentioning

confidence: 99%

“…Although there are some targeted methods for wound healing, it does not fundamentally solve the problem. 1 , 2 Wound healing consists of several distinct but overlapping stages, including haemostasis, inflammation, tissue remodelling and maturation. 3 , 4 , 5 Fibroblast, which play a significant role in wound healing, 6 could transform into myofibroblast expressing alpha‐smooth muscle actin (α‐SMA) by the influence of transforming growth factor‐β1 (TGF‐β1) after wound formation.…”

Section: Introductionmentioning

confidence: 99%

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Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast

et al. 2021

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Objectives Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulation of Hst 1 on the function of fibroblasts in the process of wound healing and preliminary mechanism about it. Materials and methods The full‐thickness skin wound model was made on the back of C57/BL6 mice. The wound healing, collagen deposition and fibroblast distribution were detected on days 3, 5 and 7 after injury. Fibroblast was cultured in vitro and stimulated with Hst 1, and then, their biological characteristics and functions were detected. Results Histatin 1 can effectively promote wound healing, improve collagen deposition during and after healing and increase the number and function of fibroblasts. After healing, the mechanical properties of the skin also improved. In vitro, the migration ability of fibroblasts stimulated by Hst 1 was significantly improved, and the fibroblasts transformed more into myofibroblasts, which improved the function of contraction and collagen secretion. In fibroblasts, mTOR signalling pathway can be activated by Hst 1. Conclusions Histatin 1 can accelerate wound healing and improve the mechanical properties of healed skin by promoting the function of fibroblasts. The intermolecular mechanisms need to be further studied, and this study provides a direction about mTOR signalling pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast

et al. 2021

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“…[ 1,2 ] The skin possesses a natural capacity for self‐regeneration; however, this process is limited in acute and extensive wounds, burns, and elderly and diabetic patients. [ 3 ] Current evidence suggests that around 100 million people require skin wound treatment every year in China, [ 4 ] and this number may continue to grow due to the aging population and increasing incidence of diseases such as obesity and diabetes. Despite autografts being considered as the gold standard treatment for skin regeneration, limitations in donor site availability and complications associated with repeated donor tissue harvesting demand new therapies for skin wound healing.…”

Section: Introductionmentioning

confidence: 99%

In Situ Precision Cell Electrospinning as an Efficient Stem Cell Delivery Approach for Cutaneous Wound Healing

Wen

Chen

Liao

et al. 2023

Adv Healthcare Materials

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Mesenchymal stem cell (MSC) therapies have been brought forward as a promising treatment modality for cutaneous wound healing. However, current approaches for stem cell delivery have many drawbacks, such as lack of targetability and cell loss, leading to poor efficacy of stem cell therapy. To overcome these problems, in the present study, an in situ cell electrospinning system is developed as an attractive approach for stem cell delivery. MSCs have a high cell viability of over 90% even with a high applied voltage of 15 kV post‐cell electrospinning process. In addition, cell electrospinning does not show any negative effect on the surface marker expression and differentiation capacity of MSCs. In vivo studies demonstrate that in situ cell electrospinning treatment can promote cutaneous wound healing through direct deposition of bioactive fish gelatin fibers and MSCs onto wound sites, leading to a synergic therapeutic effect. The approach enhances extracellular matrix remodeling by increasing collagen deposition, promotes angiogenesis by increasing the expression of vascular endothelial growth factor (VEGF) and forming small blood vessels, and dramatically reduces the expression of interleukin‐6 (IL‐6) during wound healing. The use of in situ cell electrospinning system potentially provides a rapid, no touch, personalized treatment for cutaneous wound healing.

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“…In terms of the treatment process of the disease, chronic wounds are mainly managed at home or community because of the long treatment cycle 5 . Although various regions have been exploring the establishment of wound healing centres with different operation modes, from the belief and experience of patients, especially the elderly patients, they prefer to look forward to the home wound service 6‐8 …”

Section: Introductionmentioning

confidence: 99%

“…5 Although various regions have been exploring the establishment of wound healing centres with different operation modes, from the belief and experience of patients, especially the elderly patients, they prefer to look forward to the home wound service. [6][7][8] The European Wound Management Association defines home wound care as wound care implemented at homes by health care professionals or family caregivers, excluding that in long-term care sites such as nursing homes. 9 Patients with chronic wounds are reluctant to frequently travel a long distance to receive medical service because of wound pain, physical immobility, or age factors while minimising their exposure risk.…”

Section: Introductionmentioning

confidence: 99%

Effects of home‐based chronic wound care training for patients and caregivers: A systematic review

Huang

Xie

et al. 2023

International Wound Journal

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We aimed to review and synthesise the evidence of the interventions of patients' and informal caregivers' engagement in managing chronic wounds at home. The research team used a systematic review methodology based on an updated guideline for reporting systematic reviews (PRISMA) and recommendations from the Synthesis Without Meta‐analysis. Cochrane Central Register of Controlled Trial of the Cochrane Library, Pubmed, Embase, CINAHL, Wanfang (Chinese), and CNKI database (Chinese) were searched from inception to May 2022. The following MESH terms were used: wound healing, pressure ulcer, leg ulcer, diabetic foot, skin ulcer, surgical wound, educational, patient education, counselling, self‐care, self‐management, social support, and family caregiver. Experimental studies involving participants with chronic wounds (not at risk of wounds) and their informal caregivers were screened. Data were extracted and the narrative was synthesised from the findings of included studies. By screening the above databases, 790 studies were retrieved, and 16 met the inclusion and exclusion criteria. Studies were 6 RCTs and ten non‐RCTs. Outcomes of chronic wound management included patient indicators, wound indicators, and family/caregiver indicators. Home‐based interventions of patients or informal caregivers' engagement in managing chronic wounds at home may effectively improve patient outcomes and change wound care behaviour. What's more, educational/behavioural interventions were the primary type of intervention. Multiform integration of education and skills training on wound care and aetiology‐based treatment was delivered to patients and caregivers. Besides, there are no studies entirely targeting elderly patients. Home‐based chronic wound care training was important to patients with chronic wounds and their family caregivers, which may advance wound management outcomes. However, the findings of this systematic review were based on relatively small studies. We need more exploration of self and family‐oriented interventions in the future, especially for older people affected by chronic wounds.

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Wound healing center establishment and new technology application in improving the wound healing quality in China

Cited by 12 publications

References 15 publications

Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast

Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast

In Situ Precision Cell Electrospinning as an Efficient Stem Cell Delivery Approach for Cutaneous Wound Healing

Effects of home‐based chronic wound care training for patients and caregivers: A systematic review

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