Wound healing and wound contraction after palatal surgery and implantation of poly-(L-lactic) acid membranes in beagle dogs

Braekt, Marcel M. H. In de; Alphen, Frank A. M. van; Kuijpers-Jagtman, Anne Marie; Maltha, Jaap C.

doi:10.1016/0278-2391(92)90398-j

Cited by 18 publications

(3 citation statements)

References 8 publications

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“…The epithelialization over denuded bone progressed from the periphery toward the center of the defect, advancing faster from the lateral aspect of the defect than the medial aspect ( 14 ). The epithelium was thinner than in healthy palatal mucosa, and the firmly attached connective tissue lacked elastic fibers in the early weeks of healing ( 16 , 17 , 20 ). The soft palate healed quickly.…”

Section: Discussionmentioning

confidence: 96%

Surgical Treatment and Outcome of Acquired Midline Palate Defects in Cats

2022

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Acquired midline palate defects (PDE) affect the hard palate and/or soft palate, and result from trauma, commonly falling from a height or being hit by a motor vehicle. Additional life-threating injuries and costs associated with the treatment may delay the surgical treatment. This retrospective study describes signalment, cause, and extent of the PDE, and treatment in 25 cats. In addition, the outcome of the surgical repair is described in 19 (76%) cats. All defects were repaired within 5 days of the injury. Twenty (80%) cats were 4 years of age or younger. The most common rostral extent of the PDE was to the level of the third premolar tooth (n = 8; 32%), incisor teeth (n = 7; 28%), and fourth premolar tooth (n = 5; 20%). The soft palate laceration was present in all cases. Surgical therapy was successful in all cases with follow-up. The most common techniques used for the closure of the hard palate defect were bilateral pedicle flaps with lateral releasing incisions (n = 8; 32%), direct apposition of the oral mucosa (n = 7; 28%), bilateral pedicle flaps with lateral releasing incisions and interquadrant splinting (n = 5; 20%), and unilateral pedicle flap with one lateral releasing incision (n = 4; 16%). A tension-free closure by direct apposition of the edges was possible for the soft palate laceration. No oronasal fistulae were identified at follow-up. The only complication was malocclusion. The interquadrant splinting was most often used for PDE extending to the rostral portion of the hard palate (p < 0.05). The cats that suffered postoperative malocclusion were significantly more likely to have sustained temporomandibular joint injury, underwent CT scan, or had a feeding tube placed before discharge. The results of this retrospective study indicate that the early treatment (within 5 days) of the acquired longitudinal defects in the midline of the hard and soft palates is highly successful.

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Section: Discussionmentioning

confidence: 96%

Surgical Treatment and Outcome of Acquired Midline Palate Defects in Cats

2022

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“…In the postoperative follow-up, flaps remained stable in the midline and no subjects had any wound detachment. (11,12). In another similar study, a similar cleft palate model was established in the rat palate.…”

Section: Discussionmentioning

confidence: 98%

In Vivo Use of N-Butyl-2-Cyanoacrylate in Cleft Palate Surgery and a Comparison of Its Efficacy With Suture Material

Karabulut¹,

Özbek²

2021

J Istanb Fac Med

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Objective: In this experimental work, we aimed to compare the efficacy of two different methods of combining the mucoperiosteal flaps in an animal model: using a tissue adhesive material N-butyl-2-cyanoacrylate (Glubran®2) and the classical suturing technique in cleft palate surgery.Methods: Rats were separated into group A and B. In group A (n=12) mucoperiosteal flaps were brought together with absorbable suturing material, while in group B (n=12), adhesive material was used for the same purpose. Palatal mucosa healing was evaluated histologically in terms of inflammatory cell infiltration, fibroblastic activity and vascularization on the postoperative 8 th and 16 th days.Results: As a result of this experimental study, there were no differences macroscopically in palatal mucosa healing in both groups. Histologically, on day 8, the inflammation severity was higher in the suture material group and the difference was statistically significant. On day 16, fibroblastic activity was significantly lower in the suture material group. There was no significant difference between the groups in terms of vascularity. Conclusion:As a result of these findings, Glubran®2 was found to be easily usable and effective with low complication rates, moreover, it was a practical tissue adhesive material for merging mucosal flaps in the midline of the palate.

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“…Because of natural phenomena such as the fact that a goat does not have incisor teeth, and that it pulls off food by pressing it between the tongue and the palate, resulting in heavy mechanical loading of the palatal tissues, it can be seen as a suitable model for testing intraoral use of Osmed ® expanders. Tattoos are used in several studies as a reference point or line for stereographic measurements (Wijdeveld et al 1987; In de Braekt et al 1992; Wiese 1998; Bleustein et al 2001). This method was used to determine whether soft tissue surface enlargement (expansion) took place.…”

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confidence: 99%