Wound Healing and Anti-Inflammatory Effect in Animal Models ofCalendula officinalisL. Growing in Brazil

Abstract

Calendula officinalis is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed that C. officinalis presented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.

Evaluación de extractos vegetales para manejo de quemaduras cáusticas: irritación/corrosión dérmica aguda. Bogotá/2018

“…La Calendula officinalis, comúnmente conocida como caléndula, perteneciente a la familia de las asteráceas; es una hierba aromática, erecta, anual con flores de color amarillo a naranja, utilizada en el Mediterráneo desde el siglo XIII cuando se introduce a Europa como un agente antiinflamatorio para el manejo de heridas, quemaduras de primer grado, contusiones y erupciones en piel; llegando a ser recomendada por el Gobierno Alemán en el manejo de úlceras de piernas e internamente para lesiones inflamatorias de la mucosa oral y faríngea (38).…”

Effects of heparin and hyperbaric oxygenation on necrosis reduction in an animal model for degloving injuries

“…In addition to the specific degloving wound cases, their use may be considered in any situation in which an improvement in the vascularization of the involved tissues is desired, as in cases of random skin flaps, skin grafts, chronic wounds, venous or ischemic ulcers and pressure ulcers 28 .…”

Medicinal plants with wound healing potential

“…The ethanolic extract also showed increase in collagen deposition at 4 th and 7 th postoperative days. Immunohistochemical evaluation revealed an increase in the number of blood vessels and VEGF expression in the dermis (Parente et al, 2012).…”