Wound healing activity of NOE-aspirin: A pre-clinical study

Kaushal, Mandeep; Kutty, N. Gopalan; Rao, C. Mallikarjuna

doi:10.1016/j.niox.2006.07.004

Cited by 15 publications

(9 citation statements)

References 19 publications

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“…Aspirin is one the most effective oral anti‐inflammatory medications. It retards inflammation, rendering it a potential agent for preventing HS formation 7 …”

Section: Discussionmentioning

confidence: 99%

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Improvement of hypertrophic scarring by using topical anti‐fibrogenic/anti‐inflammatory factors in a rabbit ear model

Rahmani-Neishaboor

Yau

Jalili

et al. 2010

Wound Repair Regeneration

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This study investigates the scar-reducing efficacy of topical application of stratifin and acetylsalicylic acid (ASA) in a rabbit ear model. A total of five New Zealand white rabbits with four wounds per ear were examined. Either recombinant stratifin (0.002%) or ASA (0.5%) incorporated in carboxymethyl cellulose gel was topically applied on each wound at postwounding Day 5. Scars were harvested at postwounding Day 28 for histological analysis. The wounds treated with stratifin and ASA showed 82 and 73% reduction in scar volume, respectively, compared with that of untreated controls. A reduction of 57 and 41% in total tissue cellularity along with 79 and 91% reduction in infiltrated CD3+ T cells were observed in response to treatment with stratifin and ASA, respectively, compared with those of untreated controls. Wounds treated with stratifin showed a 2.8-fold increase in matrix metalloproteinase-1 expression, which resulted in a 48% decrease in collagen density compared with those of untreated controls. Qualitative wound assessment showed a reduced hypertrophic scarring in stratifin and ASA-treated wounds when compared with the controls. This study showed that topical application of either stratifin or ASA-impregnated carboxymethyl cellulose gel reduced hypertrophic scar formation following dermal injuries in a rabbit ear fibrotic model.

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“…Aspirin is one the most effective oral anti‐inflammatory medications. It retards inflammation, rendering it a potential agent for preventing HS formation 7 …”

Section: Discussionmentioning

confidence: 99%

“…Aspirin, acetyl salicylic acid (ASA), is among the most effective oral anti‐inflammatory medications. It retards inflammation, rendering it a potential agent for preventing HS formation 7 . It reduces human T cells by inhibiting the production of Prostaglandin E2.…”

mentioning

confidence: 99%

Improvement of hypertrophic scarring by using topical anti‐fibrogenic/anti‐inflammatory factors in a rabbit ear model

Rahmani-Neishaboor

Yau

Jalili

et al. 2010

Wound Repair Regeneration

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“…in addition to its beneficial actions, aspirin (mostly at high doses) triggers serious adverse events (Woodward et al, 2011), the most problematic of which is mucosal injury to the gastrointestinal tract (Awtry and Loscalzo, 2000). Aspirin also delays the onset of labor (Sugimoto et al, 1997) and skin wound healing (Pollack, 1984;McGrath and Breathnach, 2004;Kaushal et al, 2007). However, the precise mechanisms responsible for the aspirin-related delay in wound healing are as yet wholly unknown.…”

mentioning

confidence: 99%

12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor

Liu¹,

Saeki²,

Matsunobu³

et al. 2014

J Cell Biol

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“…The area of the wound was traced on a sheet of transparent tracing paper on the day of wound generation (day 0) and on different days until healing was complete. The area of the wound was measured by super-imposing the wound tracing on a graph paper and calculating the squares (Kaushal et al, 2007). The absence of residual raw wound and falling of eschar (dead tissue remnants) was considered as the endpoint for complete epithelization (Pandarinathan et al, 1998).…”

Section: Excision Wound Modelmentioning

confidence: 99%

Wound healing activity of extracts derived fromShorea robustaresin

Khan

Ali

Pundarikakshudu

2015

Pharmaceutical Biology

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Context: Shorea robusta Gaertn.f. (Dipterocarpaceae) resin is used for treating infected wounds and burns by tribals in India. Objectives: The objective of this study was to investigate wound-healing activity of S. robusta resin extracts and essential oil in rats. Materials and methods: Methanol extract (SRME), petroleum ether, benzene insoluble fraction of methanol extract (SRPEBIME), and essential oil (SREO) of S. robusta resin were incorporated in soft yellow paraffin (10% w/w) and applied once daily on incision and excision wounds of Wistar rats. Framycetin ointment (1.0% w/w) was applied to the standard group. Tensile strength (on the 10th day), wound contraction, and scar area (on the 14th day) were recorded. On the 15th day, granulation tissues of excision wounds were analyzed for total protein, hydroxyproline, and hexosamine contents and activities of lipid peroxidation and super oxide dismutase (SOD). Histopathology of the wounds was also studied. Results and discussion: SRPEBIME and SREO healed incision and excision wounds faster than plain ointment base and framycetin. Tensile strength of SRPEBIME-treated incision wounds was 53% higher than that of control animals. In excision wounds, wound contraction and scar areas were found to be 99% and 7.7 mm 2 (SRPEBIME) and 71.7% and 21 mm 2 (control). Protein and hydroxyproline contents were higher in SRPEBIME (20.8 and 3.5% w/w) and SREO (17.4 and 2.8% w/w) groups as against 9.95 and 1.48% w/w in control groups. Histopathology revealed complete epithelization and new blood vessel formation in SRPEBIME groups. Discussion and conclusion: SRPEBIME and SREO have significant wound-healing activities on incision and excision wounds.

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Wound healing activity of NOE-aspirin: A pre-clinical study

Cited by 15 publications

References 19 publications

Improvement of hypertrophic scarring by using topical anti‐fibrogenic/anti‐inflammatory factors in a rabbit ear model

Improvement of hypertrophic scarring by using topical anti‐fibrogenic/anti‐inflammatory factors in a rabbit ear model

12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor

Wound healing activity of extracts derived fromShorea robustaresin

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