Wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana) in Wistar albino rats

Abstract

This study is designed to explore the phytochemical, antibacterial and wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana). The phytochemical analysis was performed for the methanolic stem extract of Musa paradisiaca Linn. Results indicates that the Musa paradisiaca Linn. was rich in glucosides, tannins and alkaloids, saponins, flavonoids and phenols were present in moderate quantities. The extract shows antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus with the zone of inhibition of Pseudomonas aeruginosa was 21 mm and Staphylococcus aureus was 19 mm at concentration of 500 µg/disc. The minimum inhibitory concentration (MIC) was also evaluated for the extract. Wistar albino rats were selected for wound healing activity. The burn wound was created by using red hot steel rod from above the hind limb region. The methanolic extract was applied on the wound and the progressive changes were monitored every day. The wound contraction rate was absorbed based on the histopathological examination. It was concluded that the methanolic extract of Musa paradisiaca Linn. showed greater healing activity compared to control in Wistar albino rats.

The effect of pisang ambon (Musa paradisiaca L.) stem extract on the regulation of IL-1ß, IL-6 and TNF-α in rats’ enteritis

“…The sap of the banana tree can also be used as a wound healer (6). Methanol extract of Musa paradisiaca L. can be used as wound healer (7).…”

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

“…gastrointestinal and dermatological pathogens): in vitro MIC of 15.6-125.0 mg/ml organic leaf extracts against nine bacterial strains (Karuppiah and Mustaffa, 2013). Wound healing: banana leaf wound dressings compared positively to paraffin gauze in 3 clinical trials, as reviewed (Benskin, 2013); the topically application of methanolic stem extract significantly improved wound healing in rats in comparison to control (Amutha and Selvakumari, 2016). Antileishmaniasis: significant in vitro activity of different fractions of fruit peel extracts against L. infantum chagasi promastigotes and amastigotes (Accioly et al, 2012;Silva et al, 2014).…”

Let’s Go Bananas! Green Bananas and their Health Benefits

“…When rats with colitis were treated with green banana flour, they showed an improvement in the colonic oxidative status and anti-inflammatory activity [15]. Methanolic extracts found in green bananas also promote better wound healing in rats [16,17]. Furthermore, a significant reduction of glutathione concentration in granulation tissues, percentage of wound area and increase in wound breaking strength [16] were observed in rats on a green banana diet.…”

“…For example banana leaf extracts from different species of Musa bananas have anti-bacterial activities, with Musa paradisiaca followed by Musa acuminata being the most active against multi-drug resistant nosocomial infection causing pathogens [29]. Musa paradisiaca species also demonstrates anti-bacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus [17] and anti-coccidial activity in chickens [30]. In addition, banana peel extracts show anti-microbial activities against P. gingivalis and A. actinomycetemcomitans [31].…”