Wound healing activity of &lt;i&gt; Lycopodium serratum&lt;/i&gt;

Manjunatha, B. K.; Krishna, Vijay; Vidya, S. M.; Mankani, K. L.; Manohara, Y. N.

doi:10.4103/0250-474x.33159

Cited by 22 publications

(11 citation statements)

References 8 publications

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“…Anti-inflammatory, anti-oxidant, anti-microbial activity (Orhan et al, 2007a,b), wound healing in L. serratum (Manjunatha et al, 2007), ␣-onocerin, lycopodine (Orhan et al, 2003). Skin inflammations, strains and swelling uses reported in other species of Lycopodium (Jiangsu New Medical College, 1985) Lamiaceae Coleus blumei Benth.…”

Section: Kalasana/h/t/st/tm/r (Ht2003-05)mentioning

confidence: 94%

An ethnobotanical study of traditional anti-inflammatory plants used by the Lohit community of Arunachal Pradesh, India

Namsa

Tag

Mandal

et al. 2009

Journal of Ethnopharmacology

109

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Section: Kalasana/h/t/st/tm/r (Ht2003-05)mentioning

confidence: 94%

An ethnobotanical study of traditional anti-inflammatory plants used by the Lohit community of Arunachal Pradesh, India

Namsa

Tag

Mandal

et al. 2009

Journal of Ethnopharmacology

109

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“…Preliminary phytoconstituents study of Commelina benghalensis also revealed the presence of flavanoid which are known to reduce lipid peroxidation not only by preventing or slowing the onset of cell necrosis but also by improving vascularity. [8][9][10] It is found that inhibition of lipid peroxidation property of any drug enhances the viability of collagen fibers by providing strength to collagen fibers. 11 In the present study the extract applied topically promoted the breaking strength.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Wound Healing Activity of Commelina Benghalensis Leaves Extract in Experimental Rats

JOSHI

SINGH

2019

Int J Life Sci Pharm Res

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Wound is still a worldwide health problem. Both conventional and synthetic drugs used in the treatment of wound are inadequate and sometimes they cause fatal side effects. In the absence of a reliable drug in modern medicine, there are a number of medicinal preparations in Ayurveda recommended for the treatment of wound. In view of severe undesirable side effects caused by synthetic agents, there is a growing need to follow systematic research methodology to evaluate the scientific basis for the traditional herbal medicines that are claimed to possess therapeutic effects. The benefits of herbal wound healing agents attract the researchers to evaluate their use in modern medicine and to minimize the undesirable or unpleasant effect of synthetic medicines. As we know, herbal medicines are natural in origin, safe to consume in the modern day many herbal plants like aloe, neem, turmeric, brahmi, senna, ashwagandha, asafetida, ginger, fennel, sankhpusphi, are extensively used in modern medicine and showed their potential benefits. Commelina benghalensis is a herbaceous plant growing throughout India. In our study we found that the methenolic extract of Commelina benghalensis shows significant increase in breaking strength of the skin and histopathological studies also shows increase in the number of macrophages. Various concentrations of mehenolic extract of Commelina benghalensis are used i.e 5% methenolic extract of Commelina benghalensis and 10% methenolic extract of Commelina benghalensis and both the concentration are shown to increase the breaking strength although 10 % methenolic extract shows more collegen fibres in histological section. Hence the present study is designed to evaluate wound healing of potential of Commelina benghalensis leaves in rats.

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“…In Indian traditional systems of medicine, plants have been used by traditional practitioners to promote wound healing. Many reports on the wound-healing effect of various plant extracts exist, including of Saussurea lappa (Ganachari et al 2005), Plagiochasma appendiculatum (Meenakshi et al 2006), Terminalia arjuna (Minakshi and Sushma 2006), Embelia ribes (Kumara Swamy et al 2007), Lycopodium serratum (Manjunatha et al 2007), Morinda citrifolia (Vijaykumar et al 2008), Calendula officinalis (Preethi et al 2009), Acorus calamus (Jain et al 2010), Ficus benghalensis (Garg et al 2011), Sphaeranthus amaranthoides (Geethalakshmi et al 2013), Citrus hystrix and C. maxima (Abirami et al 2015), and Aquilaria agallocha (Alam et al 2016). The Wnt/b-catenin pathway can enhance wound healing (Zhang et al 2008) by inhibiting the Glycogen synthase kinase 3-β (GSK3-β) protein, which is an important regulatory enzyme.…”

Section: Introductionmentioning

confidence: 99%

In silico and in vivo wound healing studies of ursolic acid isolated from Clematis gouriana against GSK-3 beta

Naika

Bhavana

Silva³

et al. 2016

Nusantara Biosci

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Abstract. Naika HR, Bhavana S, Teixeira da Silva JA, Lingaraju K, Mohan VC, Krishna V. 2016. In silico and in vivo wound healing studies of ursolic acid isolated from Clematis gouriana against . Clematis gouriana Roxb. (Ranunculaceae) is an endemic medicinal plant of Western Ghats. Ursolic acid (UA) was isolated from the methanolic extract (ME), which was characterized by spectral studies, and was subjected to in silico studies on Glycogen synthase kinase 3-β (GSK3-β) protein, to inhibit protein function. UA showed least binding energy (-13.457 ΔG) towards the binding site and molecular dynamics studies showed minimum potential energy and greater stability with target protein. Thus, UA may be considered as a potential inhibitor of the GSK3-β protein. The wound-healing activity was assessed by excision, incision and dead space wound models on Wistar strain rats. The results of excision, incision, and dead space wound models showed significant activity. There was a significant increase in skin-breaking strength in rats treated with UA (562.36 ± 7.60 g). The effects of ME and UA on the dead space wound model were pronounced, with a significant increase in the weight of granulation tissue (26.33  0.25 mg), tensile strength (647.00  0.71 g), and hydroxyproline content (1793.83  0.64 µg/100 g). Thus, UA-treated animals showed excellent wound-healing activity. Animals treated with nitrofurazone, ME and UA showed increased collagenation and decreased accumulation of macrophages at the site of injury.

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Wound healing activity of <i> Lycopodium serratum</i>

Cited by 22 publications

References 8 publications

An ethnobotanical study of traditional anti-inflammatory plants used by the Lohit community of Arunachal Pradesh, India

An ethnobotanical study of traditional anti-inflammatory plants used by the Lohit community of Arunachal Pradesh, India

Evaluation of the Wound Healing Activity of Commelina Benghalensis Leaves Extract in Experimental Rats

In silico and in vivo wound healing studies of ursolic acid isolated from Clematis gouriana against GSK-3 beta

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