Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.

Kumaraswamy, H M; Krishna, V.; Shankarmurthy, K; Rahiman, B. Abdul; Mankani, K. L.; Mahadevan, K. M.; Harish, B. S.; Naika, H. Raja

doi:10.1016/j.jep.2006.09.003

Cited by 133 publications

(39 citation statements)

References 4 publications

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“…Embelin was isolated from the fruits of E. schimperi and its identity was confirmed by recording IR, MS and NMR spectra and by comparison of the spectral data with those reported by other authors [18, 19]. The diammonium salt of embelin showed significant anthelmintic activity in vivo against the flat worm H. nana with 85.3 and 57.14% deparasitization and host clearance, respectively.…”

Section: Discussionsupporting

confidence: 54%

Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites

Yared

Tefera

Mekonnen

et al. 2015

BMC Complement Altern Med

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BackgroundEmbelia schimperi has been used for the treatment of intestinal parasites especially tapeworm infestations for centuries in Ethiopia. However, there is lack of scientific based evidences regarding the efficacy, safety and phytochemical analysis of this plant despite its frequent use as an anthelmintic. This study has therefore evaluated the efficacy and acute toxicity of E. schimperi thereby generating relevant preclinical information.MethodsThe anthelmintic activities of the crude hydroalcoholic extract of E. schimperi and the isolated compound, embelin, were conducted using in vivo and in vitro models against the dwarf tapeworm, Hymenolepis nana, and the hookworm, Necator americanus, respectively. LD50 of the crude hydroalcoholic extract was determined using Swiss albino mice following the OECD guidelines. Chemical characterization of the isolated embelin was conducted using UV-spectroscopy, HPLC and NMR.ResultsIn the acute toxicity study no prominent signs of toxicity and mortality were recorded among the experimental animals at the highest administered dose. Hence the LD50 of the plant was found to be higher than 5000 mg/kg. In vivo cestocidal activity of the crude hydroalcoholic extract of E. schimperi showed 100 % parasite clearance at 1000 mg/kg, while the diammonium salt of embelin showed 85.3 % parasite clearance at 750 mg/kg. The in vitro anthelminthic activity study revealed that the LC50 value of the crude extract and albendazole were 228.7 and 51.33 μg/mL, respectively.ConclusionThe results clearly indicated that the hydroalcoholic extract of E. schimperi and the diammonium salt of the isolated compound embelin had anthelmintic activity against hookworm larva in vitro and H. nana in vivo. Hence the findings of this study showed Embelia schimperi appears to possess some anthelmintic activity that may support the usage of these plants by local traditional healers to treat helminthic infestations.

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Section: Discussionsupporting

confidence: 54%

Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites

Yared

Tefera

Mekonnen

et al. 2015

BMC Complement Altern Med

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“…have also reported cardioprotective activity of the aqueous extract of E. ribes in isoproterenol-induced myocardial infarction in the rat. Wound healing activity of the embelin isolated from the leaves of E. ribes was reported by Swamy et al [11]. Chemical structure of embelin resembles the structure of natural coenzyme Q10 (ubiquinones) and the role of this is well defined in various biochemical protective mechanisms.…”

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confidence: 89%

Estimation of embelin in embelia tsjeriam-cottam fruits by HPLC to standardize harvesting time

Pandey

Ojha

2011

Indian J Pharm Sci

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Embelin (2,5-dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-benzoquinone) is a phenolic compound found in the fruits of Embelia tsjeriam-cottam and is responsible for the medicinal properties of the plant Thus the fruits are harvested at a large scale before maturity leading to depletion of population. Since the chemical constituents of medicinal plants are directly associated with the harvesting time, a study was conducted in different forest areas of Chhattisgarh, India, to standardize the harvesting time of Baividang fruits on the basis of their embelin content during 2005-08. The embelin content was determined by RP-HPLC and varied from 1.09 to 5.21% (w/w). The immature fruits collected in October contain an average of 1.67% embelin whereas mature fruits collected in December on an average contain 4.64% embelin. On the basis of our findings it can be concluded that fruits should be harvested after attaining maturity to get better quality produce and also to maintain the sustainability of plant.

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“…There is evidence in the scientific literature that the herbals in RGM possess properties such as anticancer, antioxidant, detoxification, and immune modulation. Specifically, the following herbals possess one or more of these property/properties: Acorus calamus [18, 19]; Alpinia galangal [20]; Azima tetracantha [21]; Celastrus paniculatus [22]; Cinnamomum zeylanicum [23, 24]; Clerodendron serratum [25]; Cocos nucifera [26]; C uminum cyminum [27]; Curcuma longa [3, 28]; Elettaria cardamomum [24, 29]; Embelia ribes [30, 31]; Foeniculum vulgare [32, 33]; Hygrophila auriculata [34]; Myristica fragrans [35]; Nigella sativa [3, 36, 37]; Piper longum [38]; Piper nigrum [39]; Plumbago zeylanica [40, 41]; Psoralea corylifolia [42]; Quercus infectoria [43]; Saussurea lappa [44]; Semecarpus anacardium [3, 45, 46]; Sesamum indicum [47]; Smilax china [48, 49]; Strychnos nux - vomica [50, 51]; Strychnos potatorum [52]; Terminalia chebula [53, 54]; Trachyspermum ammi [55]; Vernonia anthelmintica [56]; Vitis vinifera [57]; Withania somnifera [58]; Zingiber officinale [59–61]. Thus, cRGM presents a strong case for synergism as well as additivism of the multiplicity of compounds from the 38 herbals, most of which have been scientifically proven as associated with one or more aspects of interference with cancer.…”

Section: Discussionmentioning

confidence: 99%

Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers

Riyasdeen

Periasamy

Paul

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Rasagenthi Mezhugu (RGM) is a herbomineral formulation in the Siddha system of traditional medicine and is prescribed in the southern parts of India as a remedy for all kinds of cancers. However, scientific evidence for its therapeutic efficacy in cervical cancer is lacking, and it contains heavy metals. To overcome these limitations, RGM was extracted, and the fractions were tested on HPV-positive cervical cancer cells, ME-180 and SiHa. The extracts, free from the toxic heavy metals, affected the viability of both the cells. The chloroform fraction (cRGM) induced DNA damage and apoptosis. Mitochondria-mediated apoptosis was indicated. Though both the cells responded to the treatment, ME-180 was more responsive. Thus, this study brings up scientific evidence for the efficacy of RGM against the HPV-mediated cervical cancer cells and, if the toxic heavy metals are the limitation in its use, cRGM would be a suitable candidate as evidence-based complementary and alternative medicine for HPV-positive cervical cancers.

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Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.

Cited by 133 publications

References 4 publications

Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites

Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites

Estimation of embelin in embelia tsjeriam-cottam fruits by HPLC to standardize harvesting time

Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers

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