Wound healing activity of Dillenia ochreata leaves ethanol extract in Wistar rats

Abstract

Context: Dillenia ochreata is a medicinal plant used traditionally for scabies treatment. D. ochreata leaves contain secondary metabolites of triterpenoids, phenolics, and steroids that have the potential to accelerate the wound healing process. Aims: To determine the effect of the ethanolic extract of D. ochreata leaves on the speed of healing of burns and incisions. Methods: The test animals were divided into six groups: a positive control group (1% silver sulfadiazine ointment for burns and 10% povidone-iodine ointment for wound incision), a negative control group, and four treatment groups with an ointment concentration of 2.5, 5, 7.5, and 10%. Burns were made using a heated iron plate, and incision wounds were made using a sterile scalpel blade with a length of 3 cm. Parameters observed included burn area, incision length, percent recovery, and histopathology. Results: It was observed that the 10% concentration of D. ochreata leaf ethanol extract showed the best results in healing burns and incision wounds, with 100% healing within 12 days for burns and five days for incisions. The treatment group had a significantly different wound healing activity (p<0.05) compared with the negative control and was not significantly different (p>0.05) from the positive control. Conclusions: D. ochreata leaf ethanol extract (10%) could accelerate the healing of burns and incisions.

Evaluation of Polyphenolic Content, Antioxidant and Antimicrobial Activities, and Toxicity Study of Ferula communis L. Fruits

“…The use of plants in traditional medicine needs to be substantiated by scientific evidence regarding the efficacy, quality standards, and safety of these plants so that traditional medicines are used in accordance with established quality and safety standards. 55 Toxic substances of natural or synthetic origin can affect and damage vital organs in the body, especially the liver, which is susceptible to chemical © 2024 the authors. This work is licensed under the Creative Commons Attribution 4.0 International License attacks due to its involvement in the biotransformation of chemicals.…”

PEMBUATAN SEDIAAN SALEP EKSTRAK ETANOL DAUN SEMPRAWANG (Dilenia Ochreata) UNTUK PENGOBATAN KUDIS

“…Formula standar dasar basis salep yang digunakan terdiri dari Adeps Lanae sebanyak 15 g dan Vaselin album sebanyak 85 g dan akan dibuat basis salep sebanyak 100 g. Sediaan salep dibuat dengan konsentrasi 10 % b/b dibuat sebanyak 20 g. Salep siap untuk dikemas dengan menggunakan tube atau pot salep (Muharni et al, 2022).…”

A Subchronic Toxicity Test of Dillenia ochreata Leaves Extract on Wistar rats

“…5 Muharni et al .6 reported that D. ochreata leaves showed antibacterial activity and healing properties for burns and incision wounds. 7 D. ocheata leaves have been reported to contain sentulic acid and 3βglucopyranosyl-lup-20(29)-en-28-oat, which are active antibacterial agents against E. coli and S. aureus bacteria. Sentulic acid has been reported to have cytotoxic effects on human promyelocytic leukaemia HL-60 cells.…”