Wound Healing

Schilling, John A.

doi:10.1016/s0039-6109(16)40983-7

Cited by 135 publications

(73 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The solution curves representing damage, inflammation and fibroblasts follow the reported time course for normal wound healing. 32,33 The first experiment focused on increasing the initial wound size (D(0)52; 10-fold increase from Figure 3) while leaving pathogen levels at zero (P(0)50). Figure 4 illustrates the effect of this change on the behavior of the wound.…”

Section: Resultsmentioning

confidence: 99%

“…Assuming normal conditions, our model predicts the typical progression of healing behavior for a wound. 32,33 The ODE model was also able to successfully simulate the impairment in wound healing found in a hypoxic wound environment and a contaminated wound. With extremely low levels of oxygen, our model predicts a chronic infection where the wound does not heal and pathogens persist in the wound.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An in silico approach to the analysis of acute wound healing

Menke¹,

Cain

Reynolds

et al. 2010

Wound Repair and Regeneration

View full text Add to dashboard Cite

The complex interactions that characterize acute wound healing have stymied the development of effective therapeutic modalities. The use of computational models holds the promise to improve our basic approach to understanding the process. By modifying an existing ordinary differential equation model of systemic inflammation to simulate local wound healing, we expect to improve the understanding of the underlying complexities of wound healing and thus allow for the development of novel, targeted therapeutic strategies. The modifications in this local acute wound healing model include: evolution from a systemic model to a local model, the incorporation of fibroblast activity, and the effects of tissue oxygenation. Using these modifications we are able to simulate impaired wound healing in hypoxic wounds with varying levels of contamination. Possible therapeutic targets, such as fibroblast death rate and rate of fibroblast recruitment, have been identified by computational analysis. This model is a step toward constructing an integrative systems biology model of human wound healing.A soft tissue injury elicits a well-prescribed wound healing response.1,2 The process of wound healing is designed to restore anatomic and functional characteristics of the tissue; however, little progress has been made in improving the wound healing response time or in preventing complications such as fibrosis, infections, and formation of nonhealing wounds.3 In this paper, we describe a computational model of acute wound healing designed to allow a system-level analysis of the wound healing response using ordinary differential equations (ODEs). As a first step to a more comprehensive model, we have explored the combined effects of bacterial infections, inflammation, and tissue hypoxia on the rate and success of wound healing since these processes are well-known as affecters of healing. As this model matures, it will provide the opportunity to test new mechanisms and novel therapeutics of wound healing strategies in silico.Despite burgeoning interest in the field of computational biology, work of limited scope has been published on modeling the acute wound. Most of these studies show the difficulties of adequately accounting for the myriad of potential interactions. 4 For example, in their respective works on epidermal wound healing, Stekel et al., 5 Walker et al., 6 and Morel et al. 7 do not attempt to simulate healing by fibroblasts and do not implement inflammatory changes in their models. Dallon et al. 8 constructed an ODE model of collagen deposition focusing on the fibroblasts and their relationship to the underlying extracellular matrix, but do not account for inflammation or repair of underlying tissue damage. Schugart et al. 9 recently published a model of wound angiogenesis as a function of tissue oxygen tension but the model does not specifically address the wound healing process.Reynolds et al. 10,11 created an ODE model designed to simulate inflammation and repair on a systemic level in the setting of a systemic ins...

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An in silico approach to the analysis of acute wound healing

Menke¹,

Cain

Reynolds

et al. 2010

Wound Repair and Regeneration

View full text Add to dashboard Cite

show abstract

“…Over time, novel synthetic suture materials that can hydrolyze easily and cause less tissue reaction replaced conventional natural sutures. Polyglactin 910, which is an absorbable polyfilament suture, is safely used in gastrointestinal anastomoses, with minimal tissue reaction and resorption in 60 to 90 days [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Novel synthetic suture materials that can hydrolyze easily and cause less tissue reaction and inflammation have, for the most part, replaced conventional natural sutures [9][10][11]. After the invention of cyanoacrylate-containing industrial glues in 1949, their effect on tissues was examined [12,13].…”

mentioning

confidence: 99%

Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative?

Elemen

Sarımurat

Ayık

et al. 2009

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…23 The wound healing response can be divided into three distinct but overlapping phases: hemostasis and inflammation, proliferation, and maturation or remodeling. 24 The failure or a prolongation in one phase may result in either a delay of healing or a nonclosure of the wound. 25 Although there are some differences between the wound healing response of skin or soft tissue and the intestine, many components of the healing process are common to all tissues, such as the initial inflammatory response after injury, the deposition of new collagen, and the eventual maturation of the scar.…”

Section: Introductionmentioning

confidence: 99%

The effect of pentoxifylline on the healing of intestinal anastomosis in rats with experimental obstructive jaundice

et al. 2000

View full text Add to dashboard Cite

The aims of this study were (1) to investigate the effect of experimental obstructive jaundice on the healing of intestinal anastomosis, and (2) to investigate the effect of pentoxifylline on the healing of intestinal anastomosis in rats with obstructive jaundice. Obstructive jaundice was induced in rats by the ligation and division of the common bile duct. Four days after this operation, either pentoxifylline or isotonic saline solution was administered intraperitoneally to these jaundiced rats and controls, and then intestinal anastomosis was performed. The concentrations of serum tumor necrosis factor alpha (TNF-alpha) and serum triglyceride of jaundiced and nonjaundiced rats were measured, and the quality of healing was evaluated by measuring the bursting pressure and hydroxyproline content of the anastomoses on the fifth and tenth days of anastomotic healing. Obstructive jaundice resulted in an impaired wound healing of the intestinal anastomosis in the rats. The administration of pentoxifylline to the jaundiced rats resulted in better anastomotic wound healing. The beneficial effects of pentoxifylline on anastomotic healing in rats with obstructive jaundice was attributed to its inhibitor effect on the endotoxin-induced TNF-alpha release from macrophages and monocytes, and the stabilizing effect on the neutrophils.

show abstract

Wound Healing

Cited by 135 publications

References 2 publications

An in silico approach to the analysis of acute wound healing

An in silico approach to the analysis of acute wound healing

Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative?

The effect of pentoxifylline on the healing of intestinal anastomosis in rats with experimental obstructive jaundice

Contact Info

Product

Resources

About