Wound dressings functionalized with silver nanoparticles: promises and pitfalls

Kalantari, Katayoon; Mostafavi, Ebrahim; Afifi, Amalina M.; Izadiyan, Zahra; Jahangirian, Hossein; Rafiee-Moghaddam, Roshanak; Webster, Thomas J.

doi:10.1039/c9nr08234d

Cited by 224 publications

(134 citation statements)

References 181 publications

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“…Compared with conventional topical agents, AgNPs can both effectively prevent wound infections and improve the healing process of injured tissues. AgNPs-coated wound dressings possess considerable antibacterial activity and repair tissues faster and more efficiently [123]. Application of silver modified nanoporous silica carriers loaded with sulfadiazine instead of silver sulfadiazine could overcome the poor aqueous solubility of silver sulfadiazine which limits its antibacterial effect [124].…”

Section: Safety Of Agnps In Wound Dressing Applicationsmentioning

confidence: 99%

Silver Nanomaterials for Wound Dressing Applications

et al. 2020

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Silver nanoparticles (AgNPs) have recently become very attractive for the scientific community due to their broad spectrum of applications in the biomedical field. The main advantages of AgNPs include a simple method of synthesis, a simple way to change their morphology and high surface area to volume ratio. Much research has been carried out over the years to evaluate their possible effectivity against microbial organisms. The most important factors which influence the effectivity of AgNPs against microorganisms are the method of their preparation and the type of application. When incorporated into fabric wound dressings and other textiles, AgNPs have shown significant antibacterial activity against both Gram-positive and Gram-negative bacteria and inhibited biofilm formation. In this review, the different routes of synthesizing AgNPs with controlled size and geometry including chemical, green, irradiation and thermal synthesis, as well as the different types of application of AgNPs for wound dressings such as membrane immobilization, topical application, preparation of nanofibers and hydrogels, and the mechanism behind their antimicrobial activity, have been discussed elaborately.

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Section: Safety Of Agnps In Wound Dressing Applicationsmentioning

confidence: 99%

Silver Nanomaterials for Wound Dressing Applications

et al. 2020

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“…In particular, recent advances in tissue engineering and regenerative medicine, owing to nanotechnology, have revolutionized the fields of cardiovascular, neural, wound dressing, vascularization, bone, and other medicines. 6,7 Nanotechnology in medicine (reputed as nanomedicine) has achieved tremendous progress over the past several decades due to the close relationship between biological systems and nanoscale features. Due to the natural nanoscale features of biological systems, one can design bioassembled components and platforms using nanotechnology so it can be of great interest in life science and health care applications.…”

Section: Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

et al. 2020

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Regenerative medicine aims to engineer tissue constructs that can recapitulate the functional and structural properties of native organs. Most novel regenerative therapies are based on the recreation of a three-dimensional environment that can provide essential guidance for cell organization, survival, and function, which leads to adequate tissue growth. The primary motivation in the use of conductive nanomaterials in tissue engineering has been to develop biomimetic scaffolds to recapitulate the electrical properties of the natural extracellular matrix, something often overlooked in numerous tissue engineering materials to date. In this review article, we focus on the use of electroconductive nanobiomaterials for different biomedical applications, particularly, very recent advancements for cardiovascular, neural, bone, and muscle tissue regeneration. Moreover, this review highlights how electroconductive nanobiomaterials can facilitate cell to cell crosstalk (i.e., for cell growth, migration, proliferation, and differentiation) in different tissues. Thoughts on what the field needs for future growth are also provided.

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“…Currently, silver nanoparticles (AgNPs) have earned enormous popularity in scientific literature due to their exclusive and desirable antibacterial properties against a wide range of bacteria. [1][2][3][4][5] Antibacterial action of AgNPs can be explained by two roles, which are Ag 0 and Ag + species. [6,7] Several studies have proven that AgNPs can be accumulated in the membrane of bacteria.…”

Section: Introductionmentioning

confidence: 99%

A review of silver nanoparticles in food packaging technologies: Regulation, methods, properties, migration, and future challenges

Istiqola

Syafiuddin

2020

J Chinese Chemical Soc

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The development of antimicrobial food packaging is needed for food preservation and quality maintenance. Silver nanoparticles (AgNPs) have been widely used as an antimicrobial agent in food packaging technologies. However, the risks associated with their potential migration into foods are a major concern. This paper comprehensively reviews the use of AgNPs in food packaging technologies. The application of AgNPs in food packaging technologies has been regulated by the United States Food and Drug Administration and the European Food Safety Authority. The addition of AgNPs into food packaging can improve their barrier, mechanical, and antibacterial properties, as well as maintain the quality of foods. Migration of AgNPs from food packaging into foods is still a concern as it has implications for human health associated with their toxicity properties. A study on the toxicological properties of AgNPs released from food packaging needs to be carried out intensively to ensure their safety before being widely implemented. Moreover, comprehensive economic evaluation to implement AgNPs in food packaging is needed as such a study is missing in the literature.

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Wound dressings functionalized with silver nanoparticles: promises and pitfalls

Abstract: Infections are the main reason why most people die from burns and diabetic wounds.

Cited by 224 publications

References 181 publications

Silver Nanomaterials for Wound Dressing Applications

Silver Nanomaterials for Wound Dressing Applications

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

A review of silver nanoparticles in food packaging technologies: Regulation, methods, properties, migration, and future challenges

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