Wound Dressings Based on Sodium Alginate–Polyvinyl Alcohol–Moringa oleifera Extracts

Kamel, Samir; Dacrory, Sawsan; Hesemann, Peter; Bettache, Nadir; Ali, Lamiaa M. A.; Postel, Lou; Akl, Engy M.; El‐Sakhawy, Mohamed

doi:10.3390/pharmaceutics15041270

Cited by 8 publications

(3 citation statements)

References 42 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This aspect can be a beneficial one if we take into account the ability of the matrix to retain these particles, which is a favorable aspect for the development of materials with various encapsulated additives. The same pattern was observed by Kamel et al when they developed sodium-alginate-based materials with M. oleifera leaf extracts in their composition [43]. Thus, the material morphology was not affected by an increased level of plant composition in the matrix.…”

Section: Microstructuresupporting

confidence: 79%

Innovative Materials with Possible Applications in the Wound Dressings Field: Alginate-Based Films with Moringa oleifera Extract

Gheorghiță

Filip

Lupaescu

et al. 2023

Gels

View full text Add to dashboard Cite

For a long time, biopolymers have proven their effectiveness in the development of materials with various applications, lately those intended for the biomedical and pharmaceutical industries, due to their high biocompatibility and non-toxic, non-allergenic, and non-immunogenic nature. The ability to incorporate various active substances in this matrix has yielded materials with characteristics that are far superior to those of classic, conventional ones. The beneficial effects of consuming Moringa oleifera have promoted the use of this plant, from Ayurvedic to classical medicine. The addition of such compounds in the materials intended for the treatment of surface wounds may represent the future of the development of innovative dressings. This study followed the development of materials based on sodium alginate and moringa powder or essential oil for use as dressings, pads, or sheets. Thus, three materials with the addition of 10–30% moringa powder and three materials with the addition of 10–30% essential oil were obtained. The data were compared with those of the control sample, with sodium alginate and plasticizer. The microtopography indicated that the materials have a homogeneous matrix that allows them to incorporate and maintain natural compounds with prolonged release. For example, the sample with 30% moringa essential oil kept its initial shape and did not disintegrate, although the swelling ratio value reached 4800% after 20 min. After testing the mechanical properties, the same sample had the best tensile strength (TS = 0.248 MPa) and elongation (31.41%), which is important for the flexibility of the dressing. The same sample exhibited a very high antioxidant capacity (60.78% inhibition). The materials obtained with moringa powder added presented good values of physical and mechanical properties, which supports their use as wound dressings for short-term application and the release of embedded compounds. According to the obtained results, all the biopolymeric materials with moringa added can be used as dressings for different wound types.

show abstract

Section: Microstructuresupporting

confidence: 79%

Innovative Materials with Possible Applications in the Wound Dressings Field: Alginate-Based Films with Moringa oleifera Extract

Gheorghiță

Filip

Lupaescu

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…The wells were filled with serial dilutions of Alg/Cur extract in fibroblast medium, and the plates were then incubated at 37°C with 5% CO 2 . Using a microscope connected to a computer system, digital photographs of the 3T3 cells migrating to fill the scratched region were obtained after microscopic inspections of the scratched area at 0, 24, 48, and 72 h. 51…”

Section: Methodsmentioning

confidence: 99%

Assessing the efficacy of curcumin-loaded alginate hydrogel on skin wound healing: A gene expression analysis

Zamani,

Salehi,

Ehterami

et al. 2024

J Biomater Appl

View full text Add to dashboard Cite

Skin tissue engineering has gained significant attention as a promising alternative to traditional treatments for skin injuries. In this study, we developed 3D hydrogel-based scaffolds, Alginate, incorporating different concentrations of Curcumin and evaluated their properties, including morphology, swelling behavior, weight loss, as well as hemo- and cytocompatibility. Furthermore, we investigated the therapeutic potential of Alginate hydrogel containing different amounts of Curcumin using an in vitro wound healing model. The prepared hydrogels exhibited remarkable characteristics, SEM showed that the pore size of hydrogels was 134.64 μm with interconnected pores, making it conducive for cellular infiltration and nutrient exchange. Moreover, hydrogels demonstrated excellent biodegradability, losing 63.5% of its weight over 14 days. In addition, the prepared hydrogels had a stable release of curcumin for 3 days. The results also show the hemocompatibility of prepared hydrogels and a low amount of blood clotting. To assess the efficacy of the developed hydrogels, 3T3 fibroblast growth was examined during various incubation times. The results indicated that the inclusion of Curcumin at a concentration of 0.1 mg/mL positively influenced cellular behavior. The animal study showed that Alginate hydrogel containing 0.1 mg/mL curcumin had high wound closure(more than 80%) after 14 days. In addition, it showed up-regulation of essential wound healing genes, including TGFβ1 and VEGF, promoting tissue repair and angiogenesis. Furthermore, the treated group exhibited down-regulation of MMP9 gene expression, indicating a reduction in matrix degradation and inflammation. The observed cellular responses and gene expression changes substantiate the therapeutic efficacy of prepared hydrogels. Consequently, our study showed the healing effect of alginate-based hydrogel containing Curcumin on skin injuries.

show abstract

“…Sodium alginate is one of these reproducible plants with similar structural units to cellulose. And it is extracted from seaweed mainly applied to food [24] and health care [25,26] and can be produced at low cost using environmentally friendly processes. Its large-scale production has been very mature.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Porous Carbon Aerogel Derived from Sodium Alginate for High Performance Electrochemical Capacitor Electrode

Li,

Lai,

et al. 2023

Processes

View full text Add to dashboard Cite

To improve the performance of electrochemical capacitors, there is a notable focus on carbon materials characterized by a large surface area, reasonable pore size, pore size distribution, appropriate electronic conductivity, and excellent chemical durability. Herein, the hierarchical porous carbon aerogel originating from sodium alginate (SA) with well-defined porosity are proposed. The resultant hierarchical porous carbon aerogel shows a substantial specific surface area of 2050.6 m2 g−1 with macropores, mesopores and micropores confirmed by techniques such as TEM, SEM, BET, etc., resulting from a sequence of aerogel formation-carbonization-activation. By electrochemical measurement, the hierarchical porous carbon aerogel exhibits a specific capacitance of 204 F g−1 at an operating current density of 0.2 A g−1 employing 6 M KOH aqueous solution. The hierarchical carbon aerogel displays outstanding cycling stability with a 96.2% capacity maintenance for 10,000 cycles at an operating current density of 1 A g−1. This study presents a viable method for for preparing hierarchical porous carbon aerogel derived from biopolymer for electrochemical capacitors.

show abstract

Wound Dressings Based on Sodium Alginate–Polyvinyl Alcohol–Moringa oleifera Extracts

Cited by 8 publications

References 42 publications

Innovative Materials with Possible Applications in the Wound Dressings Field: Alginate-Based Films with Moringa oleifera Extract

Innovative Materials with Possible Applications in the Wound Dressings Field: Alginate-Based Films with Moringa oleifera Extract

Assessing the efficacy of curcumin-loaded alginate hydrogel on skin wound healing: A gene expression analysis

Hierarchical Porous Carbon Aerogel Derived from Sodium Alginate for High Performance Electrochemical Capacitor Electrode

Contact Info

Product

Resources

About