Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract

Pagano, Cinzia; Luzi, Francesca; Ricci, Maurizio; Michele, Alessandro Di; Puglia, Debora; Ceccarini, Maria Rachele; Beccari, Tommaso; Blasi, Francesca; Cossignani, Lina; Schoubben, Aurelie Marie Madeleine; Primavilla, Sara; Viseras, César; Perioli, Luana

doi:10.3390/pharmaceutics14030485

Cited by 13 publications

(8 citation statements)

References 46 publications

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“…Our previous studies demonstrated that GSE and PE could be released from GO-based aerogels , and PLA/GEL electrospun nanofibers in a rather controlled fashion, achieving release rates close to 16% after 35 days of incubation. More recently, Pagano et al investigated the release profiles of GSE loaded in acacia gum/polyvinylpyrrolidone/cyclic dextrin patches. They showed that GSE can be released in a sustained manner, reaching concentrations close to 30% after 48 h incubation.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications

Borges-Vilches,

Unalan,

Aguayo

et al. 2023

Biomacromolecules

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Chitosan (CS)-based scaffolds loaded with Pinus radiata extract bark (PE) and grape seed extract (GSE) were successfully developed for wound dressing applications. The effects of incorporating GSE and PE in CS scaffolds were investigated in relation to their physicochemical and biological properties. All scaffolds exhibited porous structures with the ability to absorb more than 70 times their weight when contacted with blood and phosphate buffer solution. The incorporation of GSE and PE into the CS scaffolds increased their blood absorption ability and degradation rates over time. All scaffolds showed a clotting ability above 95%, with their surfaces being favorable for red blood cell attachment. Both GSE and PE were released from the CS scaffolds in a sustained manner. Scaffolds loaded with GSE and PE inhibited the bacterial activity of S. aureus and E. coli by 40% and 44% after 24 h testing. In vitro cell viability studies demonstrated that all scaffolds were nontoxic to HaCaT cells. Importantly, the addition of GSE and PE further increased cell viability compared to that of the CS scaffold. This study provides a new synthesis method to immobilize GSE and PE on CS scaffolds, enabling the formation of novel material platforms with a high potential for wound dressing applications.

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Section: Resultsmentioning

confidence: 99%

Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications

Borges-Vilches,

Unalan,

Aguayo

et al. 2023

Biomacromolecules

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“…According to Ejaz et al, 23 wound contraction accounts around 88% of the healing process. The total phenols, flavonoids, and tannins found in the grape seed have been shown to be important for wound healing and antimicrobial activities 24 . Also, topical use of grapes seed hydroethanolic extract cause decreases in healing period 25 .…”

Section: Discussionmentioning

confidence: 99%

Grape seed extract promotes Staphyloccous aureus infected skin wound Healing in diabetic rat model

Hammam

Mansour

Hassan

2022

Egyptian Journal of Medical Microbiology

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Background: Open wounds leave the wound bed at risk for colonization by opportunistic pathogens. Therefore, the understanding and control of the microbial infections are of great importance for the enhanced healing and management of wounds. Reducing the wound healing time is important as it lowers the risk of infection and decreases possible complications. Grape seed extract is rich in powerful antioxidant compounds. Accordingly, grape seed extract (GSE) alone or in combination with chemical agents might be of beneficial value in wound healing. Objective: The present study aimed to evaluate the topical application of grape seed extract on wound healing of induced Staphylococcus aureus infected skin wound in diabetic rats. Methodology: Ninety male Sprague-Dawley rats weighing 150-200 grams were divided into five groups. All groups were anesthetized, shaved, and exposed to round full-thickness punch biopsy on the back: group I (control); group II (wounded); group III (wounded Staphylococcus aureus infected); group IV (wounded STZ diabetic) and group V (wounded STZ diabetic infected with Staphylococcus aureus). These last four groups were subdivided into Vaseline base treated or GSE-Vaseline treated groups. Macroscopic examination were observed at 0, 1, 3, 6, 8, 12 and 16 days after skin biopsy. Wound contraction data were expressed as a percentage of the initial wound area. Skin homogenates were prepared for determining the immunological parameters TNF-α, IL-10 TGF-β1. Results: Grape seed extract topical application improved the skin homogenate contents of TGF-β1, IL-10 and TNFα denoting the immunological effect of GSE on wound healing in different experimental groups. Skin histopathological examination was in agreement with the immunological results. Conclusion: Grape seed extract topical application promoted skin wound contraction and closure. Furthermore, it possesses antioxidant and antibacterial properties. Grape seed extract has also strong immunoregulating properties of the skin immune system in Staphylococcus aureus infected diabetic wounded rats.

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“…Cell viability was evaluated by MTT test [ 32 , 33 , 34 ]. The experiments were performed on HaCaT cells (human immortalized keratinocyte cell line), purchased from I.Z.S.L.E.R.…”

Section: Methodsmentioning

confidence: 99%

Biomaterial Inks from Peptide-Functionalized Silk Fibers for 3D Printing of Futuristic Wound-Healing and Sensing Materials

Ceccarini

Palazzi

Salvati

et al. 2023

IJMS

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This study illustrates the sensing and wound healing properties of silk fibroin in combination with peptide patterns, with an emphasis on the printability of multilayered grids, and envisions possible applications of these next-generation silk-based materials. Functionalized silk fibers covalently linked to an arginine–glycine–aspartic acid (RGD) peptide create a platform for preparing a biomaterial ink for 3D printing of grid-like piezoresistors with wound-healing and sensing properties. The culture medium obtained from 3D-printed silk fibroin enriched with RGD peptide improves cell adhesion, accelerating skin repair. Specifically, RGD peptide-modified silk fibroin demonstrated biocompatibility, enhanced cell adhesion, and higher wound closure rates at lower concentration than the neat peptide. It was also shown that the printing of peptide-modified silk fibroin produces a piezoresistive transducer that is the active component of a sensor based on a Schottky diode harmonic transponder encoding information about pressure. We discovered that such biomaterial ink printed in a multilayered grid can be used as a humidity sensor. Furthermore, humidity activates a transition between low and high conductivity states in this medium that is retained unless a negative voltage is applied, paving the way for utilization in non-volatile organic memory devices. Globally, these results pave the way for promising applications, such as monitoring parameters such as human wound care and being integrated in bio-implantable processors.

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Wound Dressing: Combination of Acacia Gum/PVP/Cyclic Dextrin in Bioadhesive Patches Loaded with Grape Seed Extract

Cited by 13 publications

References 46 publications

Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications

Multifunctional Chitosan Scaffold Platforms Loaded with Natural Polyphenolic Extracts for Wound Dressing Applications

Grape seed extract promotes Staphyloccous aureus infected skin wound Healing in diabetic rat model

Biomaterial Inks from Peptide-Functionalized Silk Fibers for 3D Printing of Futuristic Wound-Healing and Sensing Materials

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