Wound Care With a Porcine Extracellular Matrix After Surgical Treatment of Rhinophyma

Abstract

Background Rhinophyma surgery is commonly associated with prolonged wound healing and the need for multiple wound dressings. Objectives To evaluate clinical outcome with a porcine extracellular matrix (ECM) after shave excision of rhinophyma compared with common wound care procedure. Materials and methods Retrospective analysis of patients with common dressings (CD) compared with patients with additional ECM (OASIS) application. Clinical findings were assessed prior to treatment and at follow-up visit using the Patient and Observer Scar Assessment Scale (POSAS), Vancouver Scar Scale (VSS), and Rhinophyma Severity Index (RHISI). Results Overall, 28 patients (67.5 ±9.0 years) with a mean wound area of 33.9 (±8.5) cm² were included. After a mean follow-up period of 132 (±73) days, scales of POSAS, VSS, and RHISI showed significant ( P< .0001) reductions of 47.0% (±11.1), 56.0% (±12.0), and 62.3% (±14.3), respectively. Subgroup analysis showed no significant differences of aforementioned parameters between the ECM group ( n= 17) and CD group ( n= 11). In contrast, the number of dressing changes were significantly ( P< .006) less in the ECM group (1.4 ±0.8) compared with CD group (4.1 ±2.6). The ECM group showed a significant ( P< .017) shorter time to re-epithelization (10.5 ±1.7 days) than the CD group (13.1 ±2.2 days). Conclusions The application of porcine ECM is practicable and reduces the number of dressing changes and time to re-epithelization clearly. Crusts are scaling off spontaneously without any aggressive action needed. Our findings indicate that ECM application is a promising approach for rhinophyma wound care.

Rosacea Treatment: Review and Update

“…Graves and colleagues used CO 2 laser ablation in a patient with rhinophyma due to its efficacy, reliability, practicality, and predictability [67]. In a retrospective study of 28 patients, a porcine extracellular matrix was recommended for use after shave excision of rhinophyma; this treatment was found to reduce the number of dressing changes and time to reepithelization [68].…”

Efficacy and Safety of Extracellular Matrix on Wound Healing After Picosecond Laser Therapy

“…In some clinical trials, ECM-derived dressings were applied to treat patients suffering from acute and chronic wounds, demonstrating an excellent efficacy. 12–15 To the best of their knowledge, this is the first study to show that ECM can promote wound healing and alleviate adverse reactions after PLT.…”

“…11 To date, ECM and its derivatives have been tentatively applied to treat diabetic ulcers, pressure ulcers, postoperative wounds, and chronic ulcers caused by other diseases. [12][13][14][15] ECM and its derivatives achieved significantly better clinical outcomes compared with the traditional therapies in those studies, indicating that ECM has the potential to be an effective therapeutic option for treating various wounds. 16 However, the effect of ECM in facilitating wound healing after facial laser treatment has not been adequately investigated.…”

Rosacea: An Overview of Its Etiological Factors, Pathogenesis, Classification and Therapy Options

“…In a recent retrospective study involving 28 patients, it was recommended that after-shave excision of rhinophyma be complemented with the use of a porcine extracellular matrix. This treatment was found to decrease the number of dressing changes needed and reduce the time to achieve re-epithelialization [131].…”