Would Screening for Lung Cancer Benefit 75- to 84-Year-Old Residents of the United States?

Varlotto, John M.; DeCamp, Malcolm M.; Flickinger, John C.; Lake, Jessica; Recht, Abram; Belani, Chandra P.; Reed, Michael F.; Toth, Jennifer; Mackley, Heath B.; Sciamanna, Christopher N.; Lipton, A.; Ali, Suhail M.; Mahraj, Richkesvar P. M.; Gilbert, Christopher R.; Yao, Nengliang

doi:10.3389/fonc.2014.00037

Cited by 11 publications

(8 citation statements)

References 29 publications

(33 reference statements)

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“…7,153 Screening may benefit older patients who are 75 to 84 years. 154 The USPSTF recommends LDCT for individuals aged 55 to 80 years with high-risk factors. 16 The American Association for Thoracic Surgery recommends LDCT for individuals aged 55 to 79 years with high-risk factors.…”

Section: Selection Of Individuals For Lung Screeningmentioning

confidence: 99%

Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology

Wood

Kazerooni

Baum

et al. 2018

J Natl Compr Canc Netw

439

255

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Lung cancer is the leading cause of cancer-related mortality in the United States and worldwide. Early detection of lung cancer is an important opportunity for decreasing mortality. Data support using low-dose computed tomography (LDCT) of the chest to screen select patients who are at high risk for lung cancer. Lung screening is covered under the Affordable Care Act for individuals with high-risk factors. The Centers for Medicare & Medicaid Services (CMS) covers annual screening LDCT for appropriate Medicare beneficiaries at high risk for lung cancer if they also receive counseling and participate in shared decision-making before screening. The complete version of the NCCN Guidelines for Lung Cancer Screening provides recommendations for initial and subsequent LDCT screening and provides more detail about LDCT screening. This manuscript focuses on identifying patients at high risk for lung cancer who are candidates for LDCT of the chest and on evaluating initial screening findings.

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Section: Selection Of Individuals For Lung Screeningmentioning

confidence: 99%

Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology

Wood

Kazerooni

Baum

et al. 2018

J Natl Compr Canc Netw

439

255

View full text Add to dashboard Cite

show abstract

“…5 Approximately 53% of lung cancer is diagnosed in patients aged 55 to 74 years, and approximately 28% is diagnosed in older patients aged 75 to 84 years 5 ; screening may benefit the latter population. 72 The USPSTF recommends LDCT for individuals aged 55 to 80 years. 41 Similarly, the American Association for Thoracic Surgery (AATS) recommends LDCT for individuals aged 55 to 79 years who are high risk.…”

Section: Age Cutoff and Duration Of Screeningmentioning

confidence: 99%

Lung Cancer Screening, Version 1.2015

Wood¹,

Kazerooni²,

Baum³

et al. 2015

J Natl Compr Canc Netw

104

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The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide recommendations for selecting individuals for lung cancer screening, and for evaluation and follow-up of nodules found during screening, and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights focus on the major updates to the 2015 NCCN Guidelines for Lung Cancer Screening, which include a revision to the recommendation from category 2B to 2A for one of the high-risk groups eligible for lung cancer screening. For low-dose CT of the lung, the recommended slice width was revised in the table on "Low-Dose Computed Tomography Acquisition, Storage, Interpretation, and Nodule Reporting."

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“…Furthermore, it is important to consider the poor prognosis for patients with NSCLC that do not undergo any treatment. Estimated 5‐year survival in patients with Stage I NSCLC, who do not receive any form of treatment, has been shown to be as low as 7%, suggesting any treatment is beneficial even in very elderly patients . We have demonstrated that the survival probability of the resected cohort is the same as the general population matched for age and sex at the time of surgery.…”

Section: Discussionmentioning

confidence: 71%

Outcomes following resection of non‐small cell lung cancer in octogenarians

Vazirani

Moraes

Barnett

et al. 2018

ANZ Journal of Surgery

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Background: The treatment of choice for early stage non-small cell lung cancer (NSCLC) is surgical resection. Little is known about the short-and long-term outcomes among very elderly patients. We sought to determine predictors of short-and long-term survival among octogenarians undergoing curative-intent resection for NSCLC in Victoria, Australia. Methods: We retrospectively reviewed data from all patients aged ≥80 years who underwent curative-intent resection for NSCLC over 12 years (January 2005-December 2016) across five tertiary centres. We examined effect of age, stage of disease, extent of surgery and lung function on short-and long-term survival. Results: Two hundred patients aged ≥80 years underwent curative-intent resections. Mortality at 30 and 120 days was 2.9% and 5.9%, respectively. Increased early mortality was observed among those ≥83 years, at 30 days (6.8% versus 0.8%, P = 0.044) and 120 days (12.2% versus 2.3%, P = 0.0096). Early mortality was highest among patients ≥83 years requiring lobectomy, compared to sub-lobar resection at 120 days (17% versus 3.8%, P = 0.019). Long-term survival was predicted by age and stage of disease. Among patients with Stage I disease aged <83 years, lobectomy was associated with superior 5-year survival, compared to sub-lobar resection (83% versus 61%, P = 0.02). Conclusion: In carefully selected elderly patients undergoing curative-intent resection of early stage NSCLC, both short-and long-term outcomes appear consistent with younger historical cohorts. Early mortality was associated with lobectomy in those with advanced age. Older patients undergoing lobectomy appeared to be at highest risk for early mortality, while younger patients with Stage I disease undergoing at least lobectomy appear to have the best long-term survival.

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Would Screening for Lung Cancer Benefit 75- to 84-Year-Old Residents of the United States?

Cited by 11 publications

References 29 publications

Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology

Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology

Lung Cancer Screening, Version 1.2015

Outcomes following resection of non‐small cell lung cancer in octogenarians

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