Worst Pattern of Invasion as a Predictor of Nodal Metastasis in Early-Stage Oral Squamous Cell Carcinoma

Lakhera, Kamal Kishor; Nama, Yashwant; Maan, Pratibha; Jindal, Rohit; Patel, Pinakin; Singh, Suresh; Hussain, Akhlak; Sharma, Ram Babu

doi:10.1007/s13193-022-01639-y

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…This finding highlights the importance of WPOI as a potential prognostic marker in the assessment of cancer progression. 20 …”

Section: Discussionmentioning

confidence: 99%

“…This finding highlights the importance of WPOI as a potential prognostic marker in the assessment of cancer progression. 20 However, a tumour with a WPOI score of 2 (islands) in H+E may also have ITCs detected by D2-40 which drastically upgrades the probability of metastasis. This can therefore claim advantage over H+E as it helps in detecting the motile tumour phenotype, and in proving the importance of the invasive potential regardless of the histological pattern of invasion used for Bryne's grading system.…”

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confidence: 99%

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Prognostic Nomogram for Lymph-Node Metastasis in Oral Squamous Cell Carcinoma (OSCC) Using Immunohistochemical Marker D2-40

Sharma,

Natarajan,

Manaktala

et al. 2023

CMAR

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Introduction Nomograms are proven in “individualized risk prediction” in sarcomas and breast and prostate cancers. Incorporating immunohistochemical markers and histopathological parameters can enhance accuracy of these graphical representations of statistical predictive models concerning metastasis. D2-40, a monoclonal antibody to podoplanin (regulator of motility expressed in malignant epithelial cells), dually predicts metastatic potential of tumour by estimating the motile tumour phenotype and by detecting lymphatic vessels/density, both essential to metastasis in OSCC. Thus, we propose a model that incorporates D2-40 immunostaining of individual tumour cells (ITC) too with other variables (seen in H+E staining) as a predictive nomogram. Methods Sixty cases of OSCC were selected with equal number of cases ( n =30) of pN0 and pN+ status. Bryne’s grading of invasive front of tumour (ITF) was done on H+E-stained slides followed by D2-40 immunostaining for ITCs at ITF and lymphatic vessels. Multivariate regression analysis was used to generate the nomogram of LNM where the predictive contribution of each covariate, namely depth of invasion, D2-40-stained ITCs, gender, histological grade, and worst pattern of invasion (WPOI), was plotted on a scale of 1–100 points. Results The nomogram showed that the strongest variable in OSCC was the WPOI in H+E-stained section followed by D2-40-positive ITCs and gender. Discussion Our predictive nomogram for LNM in OSCC surprisingly showed that a tumour with lower score of WPOI (islands vs ITC) showed numerous D2-40-positive ITCs, drastically increasing the probability of metastasis. The concept of “individualized risk prediction” can be used to predict lymph node metastasis using a variety of histopathological criteria that can be visualized in routine and immunohistochemical staining in OSCC with the aid of a nomogram.

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“…This finding highlights the importance of WPOI as a potential prognostic marker in the assessment of cancer progression. 20 …”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Prognostic Nomogram for Lymph-Node Metastasis in Oral Squamous Cell Carcinoma (OSCC) Using Immunohistochemical Marker D2-40

Sharma,

Natarajan,

Manaktala

et al. 2023

CMAR

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Intelligent optimal archimedes shooty tern deep network (OASTDN) for oral squamous cell carcinoma detection and classification in oral cancer

Raj,

Muneeswari

2024

Multimed Tools Appl

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Pathological Risk Factors for Occult Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Oral Cavity

Dey,

Grover,

Arora

et al. 2024

Indian J Surg Oncol

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Worst Pattern of Invasion as a Predictor of Nodal Metastasis in Early-Stage Oral Squamous Cell Carcinoma

Cited by 4 publications

References 34 publications

Prognostic Nomogram for Lymph-Node Metastasis in Oral Squamous Cell Carcinoma (OSCC) Using Immunohistochemical Marker D2-40

Prognostic Nomogram for Lymph-Node Metastasis in Oral Squamous Cell Carcinoma (OSCC) Using Immunohistochemical Marker D2-40

Intelligent optimal archimedes shooty tern deep network (OASTDN) for oral squamous cell carcinoma detection and classification in oral cancer

Pathological Risk Factors for Occult Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Oral Cavity

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