Worsening Dyspnea in a Man With 2 Hearts

Pratticò, Francesco; Mugnai, Giacomo; Pavan, Michela; Trecco, Giulio; Perfetti, Paola; Rocca, Giampaolo

doi:10.1016/j.annemergmed.2011.11.039

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…There is a paucity of reports of native heart ventricular fibrillation in heterotopic heart transplant recipients with widely varying degrees of haemodynamic compromise and management strategies [1][2][3][4]. Our case adds to the literature on the roles of synchronized DC cardioversion as an effective immediate therapy and amiodarone as a secondary preventative measure for a rare but serious problem.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 52%

An Unusual Electrocardiogram in a Heart Transplant Recipient

MacLachlan

Dalzell

2015

The American Journal of Medicine

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 52%

An Unusual Electrocardiogram in a Heart Transplant Recipient

MacLachlan

Dalzell

2015

The American Journal of Medicine

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“…Although HHTx has, on average, higher morbidity and mortality rates than does orthotopic transplantation, investigators 3 have suggested that the increased risks associated with receiving heterotopic cardiac allografts can be attributed to the indications for HHTx, such as size mismatch and high TPG, rather than to the procedure itself. As the use of ventricular assist devices increases and HHTx is performed less often, some clinicians 4 have questioned whether the need for immunosuppression outweighs the risks associated with a perpetually indwelling foreign body.…”

mentioning

confidence: 99%

The Man with 2 Hearts: 25 Years from Heterotopic to Orthotopic Heart Transplantation

Godfrey

Kueht

Rana

et al. 2019

Texas Heart Institute Journal

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Substantial technological advances in mechanical circulatory support have caused a shift in the management of end-stage heart failure. From the 1970s through the 1990s, heterotopic heart transplantation was routinely performed in patients in whom orthotopic transplantation was likely to fail. Heterotopic heart transplantation is now performed less often because modern mechanical circulatory assist devices are routinely used as bridges to orthotopic transplantation; regardless, the operation has helped numerous patients who would not otherwise have received adequate allografts. We describe the case of a man with idiopathic nonischemic cardiomyopathy who, at age 17, was given an ABO- and size-matched heterotopic allograft that was a complete human leukocyte antigen mismatch. The graft functioned normally for 20 years until the patient had a myocardial infarction that necessitated placement of a coronary artery stent. Subsequent treatments involved many interventions, including insertion of an intra-aortic balloon pump, medical therapy for heart failure, implantation of a total artificial heart, and, ultimately, orthotopic transplantation. To our knowledge, our patient is the longest surviving recipient of a heterotopic heart transplant, with a remarkable 25-year graft survival despite poor histocompatibility and an almost complete lack of native heart function. The strategies used for his treatment make him a living case study that can add valuable information to the history of cardiac support.

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Worsening Dyspnea in a Man With 2 Hearts

Cited by 2 publications

References 5 publications

An Unusual Electrocardiogram in a Heart Transplant Recipient

An Unusual Electrocardiogram in a Heart Transplant Recipient

The Man with 2 Hearts: 25 Years from Heterotopic to Orthotopic Heart Transplantation

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