Worsening Depression in a Patient with a Granulosa Cell Tumor

Greenspan, Heather; Levitt, William G; Berman, J; Hussain, Asad; Waseem, Samrah; Nandu, Bharat; Nehru, Vijeyaluxmy Motilal; Jaquish, Christine

doi:10.3928/00485713-20130806-06

Cited by 1 publication

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“…These receptors are mainly expressed in the hypothalamus and amygdala [43,44,105], areas related in autonomic function and emotional regulation [34,106]. Genetic variation in the estrogen receptors may modify estrogen signaling, thus influencing a woman’s susceptibility to developing depression [107]. A study conducted on Chinese women diagnosed with major depression and healthy controls found that women carrying the genotype PP of the PvuII SNP had a higher risk of major depression compared to women with the Pp or pp genotype [108].…”

Section: Discussionmentioning

confidence: 99%

Facial Sadness Recognition is Modulated by Estrogen Receptor Gene Polymorphisms in Healthy Females

et al. 2018

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Polymorphisms of the estrogen receptor ESR1 and ESR2 genes have been linked with cognitive deficits and affective disorders. The effects of these genetic variants on emotional processing in females with low estrogen levels are not well known. The aim was to explore the impact of the ESR1 and ESR2 genes on the responses to the facial emotion recognition task in females. Postmenopausal healthy female volunteers were genotyped for the polymorphisms Xbal and PvuII of ESR1 and the polymorphism rs1256030 of ESR2. The effect of these polymorphisms on the response to the facial emotion recognition of the emotions happiness, sadness, disgust, anger, surprise, and fear was analyzed. Females carrying the P allele of the PvuII polymorphism or the X allele of the Xbal polymorphism of ESR1 easily recognized facial expressions of sadness that were more difficult for the women carrying the p allele or the x allele. They displayed higher accuracy, fast response time, more correct responses, and fewer omissions to complete the task, with a large effect size. Women carrying the ESR2 C allele of ESR2 showed a faster response time for recognizing facial expressions of anger. These findings link ESR1 and ESR2 polymorphisms in facial emotion recognition of negative emotions.

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