Worsening cholestasis and possible cefuroxime-induced liver injury following “successful” therapeutic endoscopic retrograde cholangiopancreatography for a distal common bile duct stone: a case report

Niriella, Madunil Anuk; Kumarasena, Ravindu S.; Dassanayake, Anuradha S; Pathirana, Aloka; Hewavisenthi, J.; Silva, Hithanadura Janaka de

doi:10.1186/s13256-016-1123-0

Cited by 6 publications

(5 citation statements)

References 5 publications

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“…In summary, we report that the contrast agent in ERCP and MRCP may possibly induce prolonged hyperbilirubinemia in children. 6 In this case, our patient did not receive cephalosporins after ERCP.…”

Section: Discussionmentioning

confidence: 71%

Prolonged Hyperbilirubinemia after Contrast Use in a 16-Year-Old Boy with Gilbert's Syndrome: A Case Report and Literature Review

Shin¹,

Shin²,

Han³

et al. 2021

Korean J Pancreas Biliary Tract

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Section: Discussionmentioning

confidence: 71%

Prolonged Hyperbilirubinemia after Contrast Use in a 16-Year-Old Boy with Gilbert's Syndrome: A Case Report and Literature Review

Shin¹,

Shin²,

Han³

et al. 2021

Korean J Pancreas Biliary Tract

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“…The short courses of cefuroxime (second‐generation cephalosporin) and of the herbal product (Sleep & Go®) were not considered plausible factors for DILI. Nevertheless, it should be highlighted that very few case reports have implicated cefuroxime as a cause of DILI and cholestasis, but those were calimed to be related to longer therapeutics 16,17 . Moreover, the patient's past clinical record showed no known relevant pathological history, and her case of acute viral hepatitis A at 18 years of age ended in full recovery.…”

Section: Discussionmentioning

confidence: 97%

Acute liver failure requiring transplantation: A possible link to ulipristal acetate treatment?

Dinis-Oliveira

Vieira

2021

Basic Clin Pharma Tox

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The present case describes in detail a 55‐year‐old woman diagnosed with acute liver injury 3 days after completion of the first treatment course with ulipristal acetate (UPA), 5 mg/day orally for uterine fibroids causing persistent bleeding (treatment duration of 109 days). Liver transplantation was performed approximately 6 weeks after UPA suspension, and a photograph of the explanted liver is presented. Of note, other common causes of acute liver injury, such as history of alcohol or other psychoactive substances abuse, viral hepatitis and autoimmune hepatitis or preexisting liver disease were all excluded. This case was reported to the European Medicines Agency (EMA) and contributed to the final recommendations of the Pharmacovigilance Risk Assessment Committee (PRAC) disclosed in January 2021. The causality assessment considered a probable case of drug‐induced liver injury as a consequence of UPA treatment, and the Roussel Uclaf Causality Assessment Method (RUCAM) was scored as unlikely. Although further studies are needed aiming to avoid confounding factors, this case suggests that liver function tests should be monitored during treatment with UPA.

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“…Cefuroxime is a second-generation cephalosporin. It is very rarely known to cause DILI [ 64 , 65 ]. Only case reports have been reported in the literature in which cefuroxime has been associated with hepatocellular-cholestatic hepatitis or mostly with cholestatic DILI [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Antibiotics on Functionality and Viability of Liver Cells In Vitro

Doß

Blessing

Haller

et al. 2022

CIMB

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(1) Antibiotics are an important weapon in the fight against serious bacterial infections and are considered a common cause of drug-induced liver injury (DILI). The hepatotoxicity of many drugs, including antibiotics, is poorly analyzed in human in vitro models. (2) A standardized assay with a human hepatoma cell line was used to test the hepatotoxicity of various concentrations (Cmax, 5× Cmax, and 10× Cmax) of antibiotics. In an ICU, the most frequently prescribed antibiotics, ampicillin, cefepime, cefuroxime, levofloxacin, linezolid, meropenem, rifampicin, tigecycline, and vancomycin, were incubated with HepG2/C3A cells for 6 days. Cell viability (XTT assay, LDH release, and vitality), albumin synthesis, and cytochrome 1A2 activity were determined in cells. (3) In vitro, vancomycin, rifampicin, and tigecycline showed moderate hepatotoxic potential. The antibiotics ampicillin, cefepime, cefuroxime, levofloxacin, linezolid, and meropenem were associated with mild hepatotoxic reactions in test cells incubated with the testes Cmax concentration. Rifampicin and cefuroxime showed significantly negative effects on the viability of test cells. (4) Further in vitro studies and global pharmacovigilance reports should be conducted to reveal underlying mechanism of the hepatotoxic action of vancomycin, rifampicin, tigecycline, and cefuroxime, as well as the clinical relevance of these findings.

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Worsening cholestasis and possible cefuroxime-induced liver injury following “successful” therapeutic endoscopic retrograde cholangiopancreatography for a distal common bile duct stone: a case report

Cited by 6 publications

References 5 publications

Prolonged Hyperbilirubinemia after Contrast Use in a 16-Year-Old Boy with Gilbert's Syndrome: A Case Report and Literature Review

Prolonged Hyperbilirubinemia after Contrast Use in a 16-Year-Old Boy with Gilbert's Syndrome: A Case Report and Literature Review

Acute liver failure requiring transplantation: A possible link to ulipristal acetate treatment?

Influence of Antibiotics on Functionality and Viability of Liver Cells In Vitro

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